Occurrence of cancer in women with Turner syndrome

Hasle, Henrik; Olsen, Jørgen H.; Nielsen, Jørgen G.; Hansen, Janne Hedegaard; Friedrich, Ursula; Tommerup, Niels

doi:10.1038/bjc.1996.222

Cited by 97 publications

(80 citation statements)

References 29 publications

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“…16,28 By linking a cohort of persons with a specific chromosome abnormality to other national registers, it is possible to investigate mortality and comorbidities, including cancer risk, among persons with these chromosome abnormalities. [29][30][31] In addition, this approach can allow identification of new genetic regions that might contribute to the risk for other conditions, such as autism and schizophrenia. 32,33 Results show a declining mortality rate for persons with DS over time that probably resulted from improvement in the treatment of heart malformations.…”

Section: Discussionmentioning

confidence: 99%

Survival among people with Down syndrome: a nationwide population-based study in Denmark

Zhu

Hasle

Correa

et al. 2013

Genetics in Medicine

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Section: Discussionmentioning

confidence: 99%

Survival among people with Down syndrome: a nationwide population-based study in Denmark

Zhu

Hasle

Correa

et al. 2013

Genetics in Medicine

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“…This patient also suffered from Turner syndrome. In a study of cancer incidence in a cohort of 597 women with Turner syndrome, the relative risk of CRC was rather high (6.9) [24]. However, the relationship between CRC-HAC and Turner syndrome is unclear, and there are no reports on CRC-HAC combined with Turner syndrome in the literature.…”

Section: Discussionmentioning

confidence: 99%

The effect of XELOX plus bevacizumab on rectal hepatoid adenocarcinoma

et al. 2012

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Colorectal hepatoid adenocarcinoma is rarely reported and is known to have a poor prognosis. Reports of chemotherapy against colorectal hepatoid adenocarcinoma are scarce. Here, we provide the first report of a case involving XELOX ? bevacizumab treatment of rectal hepatoid adenocarcinoma. The patient, a 40-year-old female, was diagnosed with early rectal cancer and underwent endoscopic mucosal resection. Fourteen months later, multiple lymph node metastases appeared. She received XELOX ? bevacizumab, and maintained stable disease for approximately ten months. However, unfortunately, this regimen had to be stopped because of interstitial pneumonitis. She underwent other chemotherapies and chemoradiotherapies but died approximately two years after the recurrence. Our results indicate that the XEL-OX ? bevacizumab regimen may be effective for controlling this disease.

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“…Furthermore, more cases of colon cancer than expected have been described in TS individuals [Hasle et al, 1996].…”

mentioning

confidence: 99%

“…Say et al [1971] described a 45,X patient with WT and imperforate anus. A study of cancer incidence in a cohort of 597 Danish women with TS, reported WT in one 45,X,/46,XX subject [Hasle et al, 1996]. Finally, among the 5,854 abovementioned NWTS patients, four TS cases were observed.…”

mentioning

confidence: 99%

“…The BeckwithWiedemann syndrome is linked instead to a different chromosomal region, the 11p15 band, where the WT2 gene has been mapped, although not yet identified [Koufos et al, 1989;Ping et al, 1989]. In addition to these 11p-linked congenital syndromes, WT has been rarely reported in individuals with other genetic disorders (for a review see Scott et al, 2006), including Down syndrome (DS) [Kusumakumary et al, 1995] and Turner syndrome (TS) [Say et al, 1971;Olson et al, 1995;Hasle et al, 1996].…”

mentioning

confidence: 99%

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