Occurrence of biomarkers of pesticide exposure in non-invasive human specimens

Yusà, Vicent; Millet, Maurice; Coscollà, Clara; Pardo, Olga; Roca, Marta

doi:10.1016/j.chemosphere.2015.05.082

Cited by 61 publications

(21 citation statements)

References 86 publications

(70 reference statements)

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“…Although the exposure to some pesticides such like pyrethroids or organophosphorous (OP) has already been studied worldwide through HBM studies, either in the general or in highly exposed populations including children (Kavvalakis and Tsatsakis, 2012;Morgan, 2012;Saillenfait et al, 2015;Yusa et al, 2015), only few recent results have been reported from children living in Western Europe. More specifically in Belgium, to our knowledge, the only available data were produced several years ago, focused on some OP metabolites and concerned Flemish children (Schoeters et al, 2011) whereas in Wallonia, HBM surveys are only under development and up to now have been not focused on CUPs.…”

Section: Introductionmentioning

confidence: 99%

Assessment of children’s exposure to currently used pesticides in wallonia, Belgium

et al. 2020

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In spring 2016, a study was carried out to characterize currently used pesticide (CUP) exposure among children living in Wallonia (Belgium). Pesticides were measured in both first morning urine voids of 258 children aged from 9 to 12 years and in ambient air collected close to the children's schools. Out of the 46 pesticides measured in the air, 19 were detected with frequencies varying between 11 % and 100 %, and mean levels ranging from < 0.04 to 2.37 ng/m³. Only 3 parent pesticides were found in 1-10% of the urine samples, while all the metabolites analyzed were positively detected at least once. The captan metabolite (THPI) was quantified in 23.5 % of the samples, while 3,5,6-trichloro-2-pyridinol (chlopryrifos metabolite) was detected in all urines with levels ranging from 0.36-38.96 μg/l. 3-phenoxybenzoic acid (3-PBA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (t-DCCA) and diethylphosphate were the most abundant pyrethroid metabolites and dialkylphosphate measured. The air inhalation was demonstrated to be a minor route of exposure for the selected CUPs. Statistical regressions highlighted predictors of exposure for some pesticides such like consumption of grey bread, presence of carpets at home or indoor use of pesticides, although no clear source was identified for most of them.

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Section: Introductionmentioning

confidence: 99%

Assessment of children’s exposure to currently used pesticides in wallonia, Belgium

et al. 2020

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“…Residues of permethrin and other members of the pyrethroid family in food are about 25-100 ng/15 g [39]. Furthermore, the presence of the main metabolite 3-phenoxybenzoic acid in people's urine clearly confirms population exposure to this xenobiotic [37, 40]. Due to its lipophilicity, permethrin can be easily absorbed, and we previously demonstrated that it can cross the blood-brain barrier accumulating in the brain and where it remains for a long time even after early-life exposure in rats [19].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring

Bordoni

Nasuti

Stefano

et al. 2019

Oxidative Medicine and Cellular Longevity

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Early-life exposure (from postnatal day 6 to postnatal day 21) to permethrin has been associated with long-term development of dopaminergic neurodegeneration in rats. Here, we first investigated if the dopamine decrease observed following early postnatal exposure to permethrin, an oxidative stressor, can impair the dopamine level in the brain of their untreated offspring. Secondly, we evaluated whether this adverse event affects the epigenome of both directly exposed rats (F0) and their untreated offspring (F1). The results show that early-life exposure to the stressor is associated with changes in global DNA methylation and hydroxymethylation in adult age. Furthermore, parental exposure leads to a significant reduction in dopamine level in the offspring (F1) born from parents or just mothers early-life treated (72.72% and 47.35%, respectively). About 2/3 of pups from exposed mothers showed a significant reduction in dopamine level compared to controls. Global DNA methylation and hydroxymethylation impairment was associated with the F1 pups that showed reduced dopamine. This study provides pivotal evidences on intergenerational effects of postnatal exposure to permethrin emphasizing that this xenobiotic can influence the epigenetic memory of early-life parental perturbations disturbing offspring health.

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“…Indeed, the possibility to reach extended windows of detection and to obtain information representative of the average level of xenobiotics entered into the body from a single specimen is particularly interesting in the context of chronic exposure biomonitoring. For this purpose, hair has been tested for several environmental pollutants such as metals, PCBs, and pesticides . Among other advantages, there is the easy sample collection, that does not require medical staff and facilitates patient compliance.…”

Section: Introductionmentioning

confidence: 99%

“…For this purpose, hair has been tested for several environmental pollutants such as metals, PCBs, and pesticides. [3][4][5][6][7] Among other advantages, there is the easy sample collection, that does not require medical staff and facilitates patient compliance. On the other hand, the little amount of hair typically available for the assay (tens to hundred milligrams), and the low concentration of xenobiotics in hair, require the use of highly sensitive analytical methods.…”

Section: Introductionmentioning

confidence: 99%

Determination of tebuconazole and penconazole fungicides in rat and human hair by liquid chromatography/tandem mass spectrometry

Polledri

Mercadante

Fustinoni

2018

Rapid Comm Mass Spectrometry

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RATIONALE: Tebuconazole (TEB) and penconazole (PEN) are widely applied fungicides and environmental contaminants; their toxicological properties include possible effects to the unborn child, therefore the evaluation of human exposure is relevant to risk assessment. Hair is a non-invasive specimen that incorporates pollutants allowing an extended exposure window to be surveyed. Aim of this work was to develop and validate an assay for the determination of TEB and PEN in human hair. METHODS:Under optimised conditions, analytes were extracted soaking hair in acetonitrile, in the presence of deuterated analogues, under heating and agitation. Chemical separation was achieved using a C18 reversed-phase chromatographic column and detection and quantification were performed, after a positive electrospray ionization, by triple quadrupole mass spectrometry operating in selected reaction monitoring mode. RESULTS:The assay validation showed a linear dynamic range up to 5 µg/L or 200 pg/mg hair, inter-and intra-run precisions <6%, and accuracies within 5% of spiked concentrations. Limits of quantification were 0.001 µg/L or 1 pg/mg hair for both TEB and PEN. Matrix effect experiments showed that the isotope dilution approach allowed for the control of bias sources. TEB and PEN were determined in hair of rats exposed to a low dose of TEB and in hair of agricultural workers exposed to TEB and/or PEN during the application season, indicating that both chemicals are incorporated into the hair upon exposure. CONCLUSIONS:The results of this study indicate that the developed assay is useful to evaluate the exposure to TEB and PEN in humans.3

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Occurrence of biomarkers of pesticide exposure in non-invasive human specimens

Cited by 61 publications

References 86 publications

Assessment of children’s exposure to currently used pesticides in wallonia, Belgium

Assessment of children’s exposure to currently used pesticides in wallonia, Belgium

Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring

Determination of tebuconazole and penconazole fungicides in rat and human hair by liquid chromatography/tandem mass spectrometry

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