Occurrence, distribution and risk assessment of antibiotics at various aquaculture stages in typical aquaculture areas surrounding the Yellow Sea

Zhang, Jiachao; Zhang, Xuanrui; Yang, Zhihui; Han, Q.F.; Wang, Xiaoli; Song, Chao; Wang, Shuguang; Zhao, Shan

doi:10.1016/j.jes.2022.01.024

Cited by 43 publications

(15 citation statements)

References 39 publications

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“…However, much lower concentrations of 3.5–12 µg/kg were detected in cultured fish from other typical aquaculture ( Chen et al., 2018 ). These observations indicated that the large difference of concentrations in aquatic products might be ascribed to the different potential source of MLs, including disease treatment, residues in sediments and/or water of aquaculture ponds and feeds additives ( Zhang et al., 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Occurrence and human health risk assessment of antibiotics in cultured fish from 19 provinces in China

Tang

Lou

Yang

et al. 2022

Front. Cell. Infect. Microbiol.

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The occurrence of antibiotics and potential health risk of 300 cultured fish samples from 19 provinces in China were investigated. The levels of 28 antibiotics (15 fluoroquinolones, 4 tetracyclines, 8 macrolides and rifampin) in 8 fish species were measured through liquid chromatography electrospray tandem mass spectrometry. As a result, 10 antibiotics were detected with an overall detection frequency of 24.3%, and the individual detection frequency of antibiotics ranged from 0.33 to 16.7%. The extremely high concentrations (above 100 µg/kg) of doxycycline and erythromycin were found in the samples. Antibiotics with high detection frequency was noticed in largemouth bass (41.2%), followed by snakehead (34.4%) and bream (31.2%). Specifically, Heilongjiang, Xinjiang, Qinghai and Gansu presented high detection frequency values of more than 60%. Moreover, the highest mean concentration was observed in Shandong, and the concentration covered from 34.8 µg/kg to 410 µg/kg. Despite the high detection frequency and levels of antibiotics were found in samples, ingestion of cultured fish was not significantly related to human health risks in China, according to the calculated estimated daily intakes and hazard quotients. These results provided us the actual levels of antibiotics in cultured fish and human health risk assessment of consuming fishery products.

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Section: Resultsmentioning

confidence: 99%

Occurrence and human health risk assessment of antibiotics in cultured fish from 19 provinces in China

Tang

Lou

Yang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…A recent study across aquaculture areas along the Yellow Sea in China showed that the presence of antibiotic residues in ponds increased during the culture period, in contrast to non-used ponds. A conclusion of the study was that regulations are needed to reduce antibiotic use in aquaculture (Zhang et al, 2023).…”

Section: Disease Prevention and Biosecuritymentioning

confidence: 99%

The contribution of aquaculture systems to global aquaculture production

Verdegem

Latt²,

Dalsgaard

et al. 2023

J World Aquaculture Soc

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Since 2000, aquaculture became well‐integrated into the global food system. Aquaculture systems are highly diverse, producing globally equal amounts of fed and extractive species. In Asia and Africa, inland aquaculture provides the bulk of aquaculture production, while in the Americas, Europe, and Oceania, marine aquaculture dominates. The realized growth of annual production since 2000 is due to intensification, the use of more and better feeds, improved production management, and increased attention to biosecurity. Fed and extractive aquaculture, both need to pay more attention to scaling, site selection, and the health of the wider production environment. In terms of land use, aquaculture is more efficient than terrestrial animal production. Still, water use remains a challenge. More attention should be given to water recycling in land‐based systems, reducing water consumption and facilitating nutrient recovery and reuse. Future development should focus on making aquaculture climate neutral and on reducing environmental impacts, both inland and at sea. More attention must be given to making aquaculture an important part of local food systems on all continents, as is the case in Asia today. Integration of aquaculture into local nutrition‐sensitive, circular, and sustainable food systems should become the major driver for future aquaculture system development.

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“…Antibiotic resistance is a pressing public health issue, and global efforts are required to contain it. In particular, controlling antibiotics in environmental matrices is essential as antibiotic residues entering natural ecosystems due to human activities, such as antibiotic manufacturing production and human and nonhuman antibiotic use, can facilitate rapid resistance, accelerate expansion of the environmental resistome, and increase the probability of recruitment of resistance genes into clinically relevant pathogens. − …”

Section: Introductionmentioning

confidence: 99%

Deglycosylation Inactivation Initiated by a Novel Periplasmic Dehydrogenase Complex Provides a Novel Strategy for Eliminating the Recalcitrant Antibiotic Kanamycin

Chen

Liu

Chen

et al. 2023

Environ. Sci. Technol.

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Biodegradation using enzyme-based systems is a promising approach to minimize antibiotic loads in the environment. Aminoglycosides are refractory antibiotics that are generally considered non-biodegradable. Here, we provide evidence that kanamycin, a common aminoglycoside antibiotic, can be degraded by an environmental bacterium through deglycosylation of its 4′-amino sugar. The unprecedented deglycosylation inactivation of kanamycin is initiated by a novel periplasmic dehydrogenase complex, which we designated AquKGD, composed of a flavin adenine dinucleotidedependent dehydrogenase (AquKGDα) and a small subunit (AquKGDγ) containing a twin-arginine signal sequence. We demonstrate that the formation of the AquKGDα−AquKGDγ complex is required for both the degradation activity of AquKGD and its translocation into the periplasm. Native AquKGD was successfully expressed in the periplasmic space of Escherichia coli, and physicochemical analysis indicated that AquKGD is a stable enzyme. AquKGD showed excellent degradation performance, and complete elimination of kanamycin from actual kanamycin manufacturing waste was achieved with immobilized AquKGD. Ecotoxicity and cytotoxicity tests suggest that AquKGD-mediated degradation produces less harmful degradation products. Thus, we propose a novel enzymatic antibiotic inactivation strategy for effective and safe treatment of recalcitrant kanamycin residues.

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Occurrence, distribution and risk assessment of antibiotics at various aquaculture stages in typical aquaculture areas surrounding the Yellow Sea

Cited by 43 publications

References 39 publications

Occurrence and human health risk assessment of antibiotics in cultured fish from 19 provinces in China

Occurrence and human health risk assessment of antibiotics in cultured fish from 19 provinces in China

The contribution of aquaculture systems to global aquaculture production

Deglycosylation Inactivation Initiated by a Novel Periplasmic Dehydrogenase Complex Provides a Novel Strategy for Eliminating the Recalcitrant Antibiotic Kanamycin

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