Occurrence and Treatment of Mycoplasma Genitalium in Patients Visiting STD Clinics in Sweden

Abstract

Two hundred and thirty-three men and 85 women visiting STD clinics in western Sweden between April 1997 and March 1998 were examined for Mycoplasma genitalium and Chlamydia trachomatis. The bacteria were identified by the polymerase chain reaction (PCR) technique. Three women (3.5%) and 18 men (7%) were positive for M. genitalium. Seventeen (14%) of the 115 men with urethritis were infected but only one of the men was without urethritis. After treatment with tetracyclines for 10 days, one woman and 8 of the 13 men still harboured M. genitalium. M. genitalium-infected men did not have more life-time partners than other men visiting STD clinics. More men positive for M. genitalium gave a history of previous urethritis but the difference was not significant.

Mycoplasma genitalium: prevalence and behavioural risk factors in the general population

“…For males, a low prevalence of 1.1% is also in line with other studies showing a prevalence of 1.1% in men attending a Department of Medicine for check-up 27 in Japan and prevalences of 0.8% to 8.5% among asymptomatic men seen in STD clinics. [2][3][4][5][6][7] The low coinfection rate with C trachomatis among both men and women is somewhat surprising, but in line with results found in other studies. 2 10 On the basis of the low prevalence in the general population, a widespread screening of the population between 21 and 24 years of age will not be feasible even if M genitalium at a later stage shown to be of importance in developing infertility.…”

“…1 Individuals attending sexually transmitted disease (STD) clinics have been the group most thoroughly studied and those with urethritis/cervicitis have been compared with asymptomatic STD clinic attendees. Men with urethritis had M genitalium prevalences of 9.4-29.2%, [2][3][4][5][6][7] whereas asymptomatic men in the same high-risk populations had prevalences of 0.8-8.5%. [2][3][4][5][6][7] The corresponding figures for women with cervicitis in two major studies were 10-11% 2 8 and for women without cervicitis it was 3-5%.…”

“…Men with urethritis had M genitalium prevalences of 9.4-29.2%, [2][3][4][5][6][7] whereas asymptomatic men in the same high-risk populations had prevalences of 0.8-8.5%. [2][3][4][5][6][7] The corresponding figures for women with cervicitis in two major studies were 10-11% 2 8 and for women without cervicitis it was 3-5%. The concordance rate between partners is high, ranging from 45% to 58% of female partners to male index patients 2 9 whereas 38% and 56% of male partners to female index patients have been shown to be infected.…”

Mycoplasma genitalium among Adolescent Women and their Partners

“…Point prevalence ranged from 0.8-4.1%. Previous cross-sectional studies that included some adolescents found a point prevalence between 3.5-7% [10,17,18]. The difference in point prevalence found here may be attributable to the target population for this project as the young women were not recruited from STD or family planning clinics.…”

Diagnosis and Treatment of Pelvic Inflammatory Disease

“…Most data are currently available on the pathogen M. genitalium, which has recently been implicated in PID [8,10,27,81] and tubal-factor infertility [82,83], lacks a cell wall and, therefore, is resistant to cell wall-inhibiting antibiotics, including cephalosporin. M. genitalium has been found to persist among men treated with levofloxacin [84,85] and tetracyclines [86][87][88][89] for nongonococcal urethritis. Thus, a number of currently recommended PID treatment regimens are probably insufficient for the treatment of M. genitalium upper genital tract infection.…”