Occupational asthma caused by inhaling smoke from roasting perilla seeds

Jung, Saehyun; Lee, Won Yeon; Yong, Suk Joong; Shin, Kye Chul; Kim, Chong Whan; Lee, Ji-Ho; Jung, Young-Soo; Kim, Hyun Sik; Yu, Tae-Sun; Kim, Sang-Ha

doi:10.4168/aard.2013.1.1.90

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…Researchers should keep in mind that several reports indicated a potential toxicity associated with exposure to Perilla frutescens [ 68 , 69 ], and this aspect is particularly important for those patients with severe forms of IgA in whom the estimated glomerular filtration rate is reduced and who need appropriate dose adjustments to avoid progression to end-stage renal disease and need dialysis.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

Adam

Robu

et al. 2023

Pharmaceuticals

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(1) Background: Chronic renal disorders (CRD) are associated with significant comorbidities and necessitate complex therapeutic management. As time passed, Perilla frutescens (PF) became a promising therapeutic option for CRD. The aim of this systematic review and meta-analysis was to outline the therapeutic effects of PF extracts on various models of immunoglobulin a (IgA) nephropathy; (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All prospective interventional studies that evaluated the effect of PF extract versus placebo on rat models of chronic renal disorders were assessed according to the international guidelines; (3) Results: Our search yielded 23 unique records, out of which only five were included in the analysis. Our results showed that administration of PF extracts led to a statistically significant reduction in proteinuria and PCNA levels in rats that received high doses of the extract as well as in the PCNA level and DNA synthesis in rats that received low doses of the extract. The evaluated outcomes benefited from a low degree of heterogeneity; (4) Conclusions: Some of the evaluated outcomes were significantly reduced by both high and low doses of extracts from Perilla frutescens. Further studies are needed to determine the exact effect over IgA nephropathy in human subjects.

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Section: Discussionmentioning

confidence: 99%

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

Adam

Robu

et al. 2023

Pharmaceuticals

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“…In Japan, occupational contact dermatitis is a well-known ailment among persons who come into contact with this plant [ 111 ]. Furthermore, in Korea, anaphylaxis caused by Perilla frutescens seeds [ 112 ] and occupational asthma produced by inhaling smoke from roasting these seeds [ 113 ] with an immunoglobulin E-mediated mechanism were documented.…”

Section: Miscellaneous Effectsmentioning

confidence: 99%

Applications of Perilla frutescens Extracts in Clinical Practice

et al. 2023

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(1) Background: Perilla frutescens (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell culture studies, so the clinical evidence for the therapeutic effects is poorly outlined. The aim of this review was to provide an updated and thorough understanding of Perilla frutescens applications in clinical practice using data derived from human studies, and to outline the potential directions and perspectives for further studies on this crop. (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All interventional studies that evaluated the effect of Perilla frutescens in human subjects were assessed. (3) Results: The main perspectives that can be contoured from the presented literature evaluation are an important clinical effect of Perilla frutescens extracts on allergic rhinoconjuctivitis, especially in young populations, a potent hypolipemiant effect that, in conjunction with increased serum biological antioxidant potential, determines significant improvements in cognitive function and a wide variety of miscellaneous clinical effects that need further exploration. (4) Conclusions: Supplementary research is needed in order to demonstrate the therapeutic effects of Perilla frutescens in controlled clinical settings.

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“…Because of its antioxidant and anti-allergic characteristics, perilla is often used in skin lotions, soaps, and medical preparations [69]. Perilla is also found in large amounts in the herb Houttuynia cordata Thunb (HC), which is used to treat alopecia [70].…”

Section: Uses Of Perillamentioning

confidence: 99%

Perilla Frutescens – A Review on Pharmacological Activities, Extraction Procedure and Applications

VANITA¹,

MEGH²,

SHIVAM³

2022

Asian J Pharm Clin Res

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Perilla frutescens, a member of the mint family Lamiaceae, is a medicinal, aromatic, edible, and beautiful plant. The source of perilla lies into East Asian countries (China, Japan, Korea, Taiwan, Vietnam, and India), in which it is been used as an important root of culinary and conventional medicinal uses. Perilla plant’s leaves, seeds, and stems are utilized in community medicine for a variety of ailments [1]. Recently, Perilla plant is gaining extra interest due to its medicinal advantages and phytochemical contents. The fundamental phytochemical compounds found in this species are phenolic compounds (Rosmarinic acid, caffeic acid, and ferulic acid), flavonoids (luteolin and apigenin), Phytosterols, Tocopherols, Policosanols, and Fatty acid. Perilla seed oil too is a wealthy supply of vital fatty acid which includes α-linolenic acid (54–64%) and linoleic acid (14%) [2]. Perilla has shown different biologicalactions for example, antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer, and neuroprotective actions. Perilla seed oil consists of omega-3-fatty acid, and alpha-linolenic acid (ALA). In comparison to other plant oils, perilla seed oil has one of the highest percentages of omega-3 (ALA) fatty acids, at 54–64%. The omega-6 (linoleic acid) is around 14% and omega-9 (Oleic acid) too is found in perilla oil. These polyunsaturated fatty acids are very useful to human wellbeing and in prevention of various illnesses such as cardiovascular disorders, cancer, inflammatory, and rheumatoid arthritis [3].

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Occupational asthma caused by inhaling smoke from roasting perilla seeds

Cited by 8 publications

References 14 publications

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

Applications of Perilla frutescens Extracts in Clinical Practice

Perilla Frutescens – A Review on Pharmacological Activities, Extraction Procedure and Applications

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