Applications of Perilla frutescens Extracts in Clinical Practice

Abstract

(1) Background: Perilla frutescens (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell culture studies, so the clinical evidence for the therapeutic effects is poorly outlined. The aim of this review was to provide an updated and thorough understanding of Perilla frutescens applications in clinical practice using data derived from human studies, and to outline the potential directions and perspectives for further studies on this crop. (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All interventional studies that evaluated the effect of Perilla frutescens in human subjects were assessed. (3) Results: The main perspectives that can be contoured from the presented literature evaluation are an important clinical effect of Perilla frutescens extracts on allergic rhinoconjuctivitis, especially in young populations, a potent hypolipemiant effect that, in conjunction with increased serum biological antioxidant potential, determines significant improvements in cognitive function and a wide variety of miscellaneous clinical effects that need further exploration. (4) Conclusions: Supplementary research is needed in order to demonstrate the therapeutic effects of Perilla frutescens in controlled clinical settings.

Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial

“…Perilla frutescens (L.) Britt. (PF) is a prominent oilseed crop utilized as a source of edible vegetable oil, traditionally considered a health food in Asian countries such as Korea, China, and Japan ( 23 , 24 ). In comparison to other edible vegetable oils, perilla seed oil (PO) is primarily consists of PUFA (76 ~ 93%), ALA(57 ~ 62%) and LA(14 ~ 18%) ( 25 ), with ALA, an essential n-3 PUFA, being the most abundant ( 26 ).…”

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

“…A recent literature review outlined the main applications of Perilla frutescens in clinical practice using data derived from human studies and indicated that the extracts from this herb have demonstrated anti-inflammatory, antiallergic, antioxidant, and hypolipemiant effects in humans [ 30 ]. Other miscellaneous effects referred to its antibacterial and antifungal proprieties as well as its role as a prebiotic and reliever of gastrointestinal discomfort.…”

Therapeutic Effects of Perilla Phenols in Oral Squamous Cell Carcinoma

“…Perilla frutescens (known as perilla), a plant commonly consumed in many regions of Asia, contains complex phytochemical constituents, such as flavonoids, volatile oils, unsaturated fats, triterpenoids, and phenols [1,2]. Because of their multiple aromatic rings and several hydroxyl groups, the phenols in P. frutescens cause the plant to exert considerable antioxidant effects [2,3]. Perilla also exhibits potent anti-inflammatory properties [4].…”

“…Chronic inflammation contributes to a microenvironment favoring the development and progression of various cancers, such as oral squamous cell carcinoma (OSCC) [5,6], renal cell carcinoma (RCC) [7], and colon cancer [8]. Because oxidative stress and inflammation are the causes of several pathological conditions, different parts of the perilla plant have long been used as traditional Chinese medicines to alleviate coughs, asthma, and constipation [2]. Hong demonstrated that perilla leaf extract (PLE) is a potent anti-SARS-CoV-2 agent that is capable of inhibiting SARS-CoV-2 replication [9].…”