Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Ten, Jorge; Mendiola, Jaime; Torres-Cantero, Alberto M.; Moreno-Grau, José M.; Moreno‐Grau, Stella; Roca, Manuela; Romero, J.M. Bernal; Bernabéu, Rafael

doi:10.2174/1874255600801010016

Cited by 21 publications

(12 citation statements)

References 114 publications

(123 reference statements)

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“…Previous exposure to glycol ethers in work place associated with decrease in the semen quality [25]. Semen quality in workers exposed occupationally to hydrocarbons like toluene, benzene and xylene present anomalies, including alterations in viscosity, liquefaction capacity, sperm count, sperm motility, and the proportion of sperm with normal morphology compared with unexposed males [26]. Furthermore, welding may reduce the quality and quantity of semen, likewise, occupations in which the workers exposed to heat they have reduced sperm count.…”

Section: Occupational Exposurementioning

confidence: 99%

Risk Factors and Causes of Male Infertility-A Review

Mahat¹,

Arora²

2016

Biochem Anal Biochem

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Infertility is defined as inability to achieve conception in a period of one year in a couple, despite regular and adequate unprotected sexual intercourse. A male is said to be infertile if he is unable to impregnate his partner after one year of unprotected intercourse. It is an important medical and social problem in the world as regards 15% of couples are infertile and 40% are infertile because of male factor infertility. This review highlights the risk factors and some causes that are responsible for male infertility. The aim of this review is to generate information which could help in the evaluation of male infertility.

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Section: Occupational Exposurementioning

confidence: 99%

Risk Factors and Causes of Male Infertility-A Review

Mahat¹,

Arora²

2016

Biochem Anal Biochem

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“…Environmental pollutants, occupational exposures and life style factors have been explored as possible contributors [3]. Toxicants affecting the reproductive system are broadly categorised as petroleum products, agrochemicals, industrial chemicals and heavy metals.…”

Section: Introductionmentioning

confidence: 99%

Environmental and occupational exposures as a cause of male infertility: A caveat

et al. 2015

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Objectives To determine the association between environmental and occupational exposures, semen parameters and lead (Pb) and cadmium (Cd) levels in seminal plasma of men investigated for infertility.Methods Data were collected from 300 men investigated for infertility using an interviewer administered questionnaire. Seminal fluid analysis and classification was done according to WHO guidelines. Positive exposure was defined as environmental or occupational exposure to agro or industrial chemicals, heavy metals and living in areas within 50m of potential sources of pollution for three months or more. Seminal plasma lead and cadmium levels were estimated by graphite furnace atomic absorption spectrophotometry after digestion with nitric acid. The means of sperm parameters, Pb and Cd concentrations between exposed and non exposed groups were compared using t-test.Results Mean age was 34.8 (95% CI 34.2-35.4) years BMI was 24.3 (95% CI 23.8-24.7) kg/m 2 and duration of the infertility was 45.7 (41.7-49.6) months. In this study, 54.6% were exposed to toxins through environmental or occupational sources. All sperm parameters were lower in the exposed group when compared to the non exposed. Lead and cadmium were detected in 38.3% and 23% of men respectively. The distance from the source of possible environmental or occupational exposure was negatively correlated to seminal plasma Pb (r=0.06, p>0.05) and Cd (r=0.26, p<0.05) concentrations. In the exposed, mean IntroductionGlobally, human fecundity appears to be on the decline with decrease in semen quality and male infertility being on the rise [1,2]. Environmental pollutants, occupational exposures and life style factors have been explored as possible contributors [3]. Toxicants affecting the reproductive system are broadly categorised as petroleum products, agrochemicals, industrial chemicals and heavy metals. The effects of exposure to toxicants and male infertility have been reported by many investigators [4]. However the results vary according to the study population, the methods used in the assessment of exposure and the biological end point.Of the heavy metals known to impair semen quality, lead (Pb) and cadmium (Cd) are the two most prevalent Ceylon Medical Journal 2015; 60: 52-6 lead concentration was 17.7 (95% CI 15.0-20.4) µg/dl and 13.5 (95% CI 11.2-15.7) µg/dl in non exposed and cadmium concentration in exposed was 1.2 (95% CI 1.1-1.4) µg/dl and 1.1 (0.9-1.3) µg/dl in non-exposed.Conclusions Environmental and occupational exposures were associated with reduced sperm count motility, viability, normal forms and detectable levels of lead and cadmium in seminal plasma.

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“…Of the potential risks for reproductive health, special concern was given to the ability of a great number of xenobiotics (including medicines) to affect the function of the male reproductive system (Ten et al , 2008). …”

Section: Introductionmentioning

confidence: 99%

Damage of testicular cell macromolecules and reproductive capacity of male rats following co-administration of ethambutol, rifampicin, isoniazid and pyrazinamide

Shayakhmetova¹,

Bondarenko²,

Коваленко³

2012

Interdisciplinary Toxicology

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The necessity to minimize adverse effects of tuberculosis chemotherapy requires a comprehensive evaluation of the effects of antituberculosis drugs on the reproductive system and testicular cell macromolecules. The epidemiological situation of tuberculosis in Central and Eastern Europe is getting worse. Data on adverse effects of antituberculosis drugs are scare concerning particularly their effects on the reproductive system. The aim of the present study was to investigate the potential effect of ethambutol, rifampicin, isoniazid and pyrazinamide co-administration on lipid peroxidation, glutathione content and protein SH-groups, DNA fragmentation levels, the reproductive capacity of Wistar male rats and the antenatal development of their posterity. The rats (150–170 g) were divided into two groups: group I – received antituberculosis drugs suspended in 1% starch gel per os: ethambutol – 155 mg/kg b.w./day, rifampicin – 74.4 mg/kg b.w./day, isoniazid – 62 mg/kg b.w./day, pyrazinamide – 217 mg/kg b.w./day, group II (control) – received only starch gel in corresponding volumes. The contents of TBA-active compounds, glutathione and protein SH-groups in testis and sperm were determined spectrophotometrically, the DNA-fragmentation was determined using an UV transilluminator (BIORAD, USA), reproductive system indices were measured by standard methods. The co-administration of therapeutic doses of ethambutol, isoniazid, rifampicin and pyrazinamide to male rats during the period of spermatogenesis caused an increase in the rate of thiobarbituric acid reactive substances formation in testis and sperm, decrease of testis glutathione and protein SH-group contents, significant changes in DNA fragmentation, fatal decrease of male fertilizing capacity and fertility, and increase of pre- and post-implantation embryo lethality. The changes in reproductive indices could be the result of direct or indirect effects of one or more drugs investigated.

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Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Cited by 21 publications

References 114 publications

Risk Factors and Causes of Male Infertility-A Review

Risk Factors and Causes of Male Infertility-A Review

Environmental and occupational exposures as a cause of male infertility: A caveat

Damage of testicular cell macromolecules and reproductive capacity of male rats following co-administration of ethambutol, rifampicin, isoniazid and pyrazinamide

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