Obstructive Sleep Apnea Syndrome Is Associated With Some Components of Metabolic Syndrome

Kono, Masakazu; Tatsumi, Koichiro; Saibara, Toshiji; Nakamura, Akira; Tanabe, Nobuhiro; Takiguchi, Yuichi; Kuriyama, Takayuki

doi:10.1378/chest.06-1807

Cited by 197 publications

(138 citation statements)

References 24 publications

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“…In the present study, total cholesterol and LDL cholesterol were not increased in patients with OSA, in agreement with several previous reports [11,35,36]. In contrast, HDL cholesterol levels were inversely related to indices of OSA severity, and these relationships remained significant after adjustments for all relevant covariates.…”

Section: Discussionsupporting

confidence: 93%

Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea

Tisko

Sopkova

Habalová

et al. 2013

European Respiratory Journal

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There is increasing evidence that intermittent hypoxia resulting from obstructive sleep apnoea (OSA) is independently associated with dyslipidaemia. Currently, no data exist on potential links between OSA-related dyslipidaemia and susceptibility genes for dyslipidaemia in such patients. Our aim was to study the effects of the apolipoprotein E (APOE) genotype and sleep apnoea severity on atherogenic dyslipidaemia in patients with OSA.519 clinically stable subjects prospectively recruited at a tertiary referral teaching hospital underwent full polysomnography. APOE gene polymorphisms were assessed using real-time PCR.In all APOE genotype groups, serum triglycerides increased while high-density lipoprotein (HDL) cholesterol was reduced with increasing severity of OSA in each APOE genotype group, whereas the deleterious effects of OSA on serum apolipoprotein (Apo)B levels were observed in e2 carriers and the e3/e3 genotype only. Nevertheless, the e4 allele carriers had ApoB levels within the risk range, irrespective of nocturnal hypoxia. In addition, among patients with the high-risk e4 genotype, those with the most severe nocturnal hypoxia had significantly higher triglyceride and lower HDL cholesterol levels compared with nonhypoxic e4 subjects. APOE genotype and the oxygen desaturation index were both independent predictors of serum triglyceride levels (p50.009 and p,0.001, respectively; R 2 50.148) and ApoB levels (p50.001 and p50.003, respectively; R 2 50.104). Our findings suggest that OSA has adverse effects on several lipid parameters over and above the effects carried by APOE genotype. Further st1udies are needed to analyse the effects of high-risk genotypes on metabolic and cardiovascular outcomes in patients with OSA. @ERSpublications OSA has adverse effects on several lipid parameters in addition to the effects carried by the APOE genotype

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Section: Discussionsupporting

confidence: 93%

Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea

Tisko

Sopkova

Habalová

et al. 2013

European Respiratory Journal

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“…Still an association between OSA and lipid profile is unclear. Many studies support the notion that OSA is independently associated with lipid abnormalities, while others show that dyslipidaemia occurring in OSA is related to obesity and not directly to OSA [36]. In the present study we did not observe any change in lipid profile after one night of CPAP therapy which is similar to the findings of our previous study [6] where two nights of CPAP treatment did not show changes in lipid profile.…”

Section: Resultssupporting

confidence: 91%

Effect of Short Term C PAP Therapy in Obstructive Sleep Apnea Patients with Metabolic Syndrome

Kanimozhi

Chilukuri

Saravanan

et al. 2015

JCDR

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Background: Patients of obstructive sleep apnea (OSA) with metabolic syndrome (MetS) are at increased risk of cardiovascular morbidity and mortality. The role of oxidative stress in pathogenesis of OSA and MetS has been widely reported. Continuous positive airway pressure (CPAP) therapy remains the first-line of treatment in OSA. The beneficial effect of long term CPAP therapy in OSA is well-known. However, the effect of short term CPAP on the components of MetS and oxidative stress-antioxidant levels is still unclear.Aim: The present study explored the effects of one night of CPAP therapy on the oxidant-antioxidant status and components of MetS in patients of OSA with MetS.

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“…It has also been shown that, independent of visceral fat obesity, OSA is associated with hypertension, dyslipidemia and hyperglycemia, all of which are components of MetS 18) . On the other hand, few data are available regarding the rate and severity of OSA in patients with obesity and MetS.…”

Section: Discussionmentioning

confidence: 99%

Effects of Weight Reduction Therapy on Obstructive Sleep Apnea Syndrome and Arterial Stiffness in Patients with Obesity and Metabolic Syndrome

Iguchi

Tochiya

Muranaka

et al. 2013

JAT

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Aim: Obesity and metabolic syndrome (MetS) and obstructive sleep apnea (OSA), which are often accompanied by obesity, are each independently associated with cardiovascular disease (CVD). However, the influence of OSA on arterial stiffness in obese patients remains unclear. We herein examined the relationships between the severity of OSA and CVD risk factors, including the severity of MetS and arterial stiffness, in obese patients. In addition, we evaluated the effects of weight reduction therapy on OSA and arterial stiffness.

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Obstructive Sleep Apnea Syndrome Is Associated With Some Components of Metabolic Syndrome

Cited by 197 publications

References 24 publications

Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea

Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea

Effect of Short Term C PAP Therapy in Obstructive Sleep Apnea Patients with Metabolic Syndrome

Effects of Weight Reduction Therapy on Obstructive Sleep Apnea Syndrome and Arterial Stiffness in Patients with Obesity and Metabolic Syndrome

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