Effects of Weight Reduction Therapy on Obstructive Sleep Apnea Syndrome and Arterial Stiffness in Patients with Obesity and Metabolic Syndrome

Iguchi, A; Tochiya, Mayu; Muranaka, Kazuya; Sasaki, Yukiyoshi; Kono, Shigeo; Shimatsu, Akira; Satoh‐Asahara, Noriko

doi:10.5551/jat.17632

Cited by 33 publications

(40 citation statements)

References 32 publications

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“…We previously reported that 3-month weight reduction therapy significantly reduced several cardiovascular risk factors, such as oxidized LDL (an atherogenic lipoprotein), an atherogenic index, and obstructive sleep apnea syndrome [17,19,28]. It was also reported that within the general population, falls in IAFA within 1 year were associated with a significant decrease in the number of metabolic risk factors, irrespective of BMI [29].…”

Section: Discussionmentioning

confidence: 95%

The utility of dual bioelectrical impedance analysis in detecting intra-abdominal fat area in obese patients during weight reduction therapy in comparison with waist circumference and abdominal CT

et al. 2014

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Section: Discussionmentioning

confidence: 95%

The utility of dual bioelectrical impedance analysis in detecting intra-abdominal fat area in obese patients during weight reduction therapy in comparison with waist circumference and abdominal CT

et al. 2014

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“…The principles of CAVI measurement were previously described by Yamabe et al 11) . Classical cardiovascular risk factors, including body mass index (BMI), and the cluster of risk factors comprising metabolic syndrome (MetS), are positively associated with arterial stiffness [12][13][14] . However, there Wen Wen and Bin Peng contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of High Arterial Stiffness and Gender-specific Differences in the Relationships with Classical Cardiovascular Risk Factors

Wen

Peng

Tang

et al. 2015

J Atheroscler Thromb

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Aim:To investigate the relationships between arterial stiffness and classic cardiovascular risk factors with respect to gender differences in addition to the prevalence of high arterial stiffness in Chongqing, China based on an examination of 18,336 subjects. Methods: The cardio-ankle vascular index was used as a marker of arterial stiffness. The relationships between arterial stiffness and body mass index (BMI) as well as metabolic syndrome (MetS) were estimated using logistic regression models. Results: The prevalence of high arterial stiffness was 12.74% in men and 9.91% in women. For age and BMI, compared with the reference group, men had higher adjusted odds ratios (ORs) in each group versus their female counterparts. For each individual index of MetS, the effects of waist circumference and systolic blood pressure (SBP) on high arterial stiffness exhibited remarkable gender differences, with women having higher ORs and adjusted ORs than men. As the sum of MetS traits increased, the ORs and adjusted ORs in the subjects also increased, with women having higher values than men in each group. Conclusions: Gender-specific differences exist in the prevalence of high arterial stiffness among subjects compared by age, BMI and MetS, with varying effects of influence for these factors between genders.J Atheroscler Thromb, 2015; 22: 706-717.

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“…Nevertheless, both studies indicate that subjects with obesity and OSA have a higher risk of arterial stiffness. Iguchi et al 16) recently reported a significant correlation with severe NIH and increased arterial stiffness. The interaction test showed a trend for an overweight status to be a modifier of the association between OSA and increased arterial stiffness (p = 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…Short-and long-term continuous positive airway pressure (CPAP) therapy was found to significantly reduce CAVI 15) . It has also been shown that short-term weight reduction therapy improves not only metabolic dysfunction, but also the severity of OSA and arterial stiffness, as measured by CAVI 16) . The measurement of CAVI has demonstrated good reproducibility and was not affected by the blood pressure during measurement 17,18) .…”

Section: Assessment Of Nihmentioning

confidence: 99%

Relationships between Nocturnal Intermittent Hypoxia, Arterial Stiffness and Cardiovascular Risk Factors in a Community-based Population: The Toon Health Study

Alberto

Tanigawa

Maruyama

et al. 2014

JAT

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Aim: Nocturnal intermittent hypoxia (NIH), a primary marker of obstructive sleep apnea, has increasingly been linked with cardiovascular morbidity and mortality. The purpose of this study was to investigate the association between NIH and arterial stiffness as measured according to the cardio-ankle vascular index (CAVI) based on cardiovascular risk factors in a Japanese community-dwelling population. Methods: We conducted a cross-sectional study in Toon city among 684 men and 1,241 women 30-79 years of age. The severity of NIH was defined as mild or moderate-to-severe according to five or 15 events/hour on the 3% oxygen desaturation index (ODI), respectively. Increased arterial stiffness was diagnosed according to a CAVI of ≥ 9. Results: The number of subjects with no, mild and moderate-to-severe NIH was 1,348 (70%), 451 (23%) and 126 (7%), respectively. Increased arterial stiffness was detected in 21.9% of the participants. The multivariable-adjusted odds ratio (95% CI) of severe NIH related to an increased CAVI in comparison with a 3% ODI of ＜5 was 1.36 (0.82-2.23). The stratified logistic regression analysis showed that the multivariable-adjusted OR of severe NIH for an increased CAVI was remarkably increased in the individuals with a BMI of ≥ 25 (OR = 2.53, 1.08-5.96; p = 0.03). An interaction test showed a trend for an overweight status to be a modifier of the association between OSA and increased arterial stiffness (p = 0.05). Conclusions: NIH has a tendency to promote increased arterial stiffness as measured according to the CAVI, especially in overweight subjects.

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Effects of Weight Reduction Therapy on Obstructive Sleep Apnea Syndrome and Arterial Stiffness in Patients with Obesity and Metabolic Syndrome

Cited by 33 publications

References 32 publications

The utility of dual bioelectrical impedance analysis in detecting intra-abdominal fat area in obese patients during weight reduction therapy in comparison with waist circumference and abdominal CT

The utility of dual bioelectrical impedance analysis in detecting intra-abdominal fat area in obese patients during weight reduction therapy in comparison with waist circumference and abdominal CT

Prevalence of High Arterial Stiffness and Gender-specific Differences in the Relationships with Classical Cardiovascular Risk Factors

Relationships between Nocturnal Intermittent Hypoxia, Arterial Stiffness and Cardiovascular Risk Factors in a Community-based Population: The Toon Health Study

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