Obstruction of Aqueous Humor Outflow by Cross-linked Polyacrylamide Microgels in Bovine, Monkey, and Human Eyes

Kaufman, Paul L.; Lütjen–Drecoll, Elke; Hubbard, William C.; Erickson, Kristine

doi:10.1016/s0161-6420(94)31116-x

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…In an experimental study with Orcolon, a synthetic viscoclastic, microscopic examination showed accumulation of microgels in the cribriform meshwork and beneath the innerwall of Schlemm's canal. This may be the reason why the IOP was higher and the facility of outflow reduced by the viscoelastic (Kaufmann et al 1994). NaHa in rabbit eyes produced a mild granulocytic response and there was no difference between Amvisc and Hea-Ion (Mc Knight et al 1978).…”

Section: Resultsmentioning

confidence: 99%

A comparison of Healon and Amvisc on the early postoperative pressure after extracapsular cataract extraction with implantation of posterior chamber lens

Anmarkrud

Bergaust

Bulie

1996

Acta Ophthalmologica Scandinavica

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Two viscoelastic agents, Healon and Amvisc, both hyaluronic acids, were evaluated in two prospective, randomized and masked studies in order to compare the effects of the viscoelastics and timolol (Blocadren ) on the early postoperative intraocular pressure (IOP) after planned extracapsular cataract extraction with implantation of a posterior chamber lens. The study protocols were similar, especially with regard to the sample size, pre-, per- and postoperative management and sampling. The IOP was measured preoperatively, 3-6 and 24 h postoperatively. The testing of Amvisc revealed that aspiration or non-aspiration of Amvisc at the end of surgery was of little importance for the IOP, and that timolol significantly reduced the IOP 3-6 h postoperatively in the order of about 8 mmHg. The postoperative IOP was lower for Amvisc than for Healon only when the viscoelastic material was aspirated and topical timolol was administered. In all the other groups there were no significant differences between the viscoelastics as far as the postoperative pressure was concerned. Multiple regression revealed a marked pressure reducing effect of timolol 3-6 h postoperatively in both groups, but no effect was observed 24 h postoperatively. The two viscoelastic agents showed minor effect on the IOP both 3-6 and 24 h postoperatively.

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Section: Resultsmentioning

confidence: 99%

A comparison of Healon and Amvisc on the early postoperative pressure after extracapsular cataract extraction with implantation of posterior chamber lens

Anmarkrud

Bergaust

Bulie

1996

Acta Ophthalmologica Scandinavica

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“…Due to the addition of alkaline compounds, salt formation and subsequent repulsion between anions cause the formula to gel [18,19]. The carbomer molecule has inherent bioadhesive, viscoelastic, and rheologic properties, and has been studied extensively for use in ophthalmology [20] and reconstructive surgery in human medicine. Additionally, carbomers are generally inert biologically and nonirritating [21,22].…”

Section: Introductionmentioning

confidence: 99%

Carbomer Viscosupplementation in the Equine Middle Carpal Joint

2014

J Veterinar Sci Technol

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Joint visco supplementation is widely used in the sport horse industry, commonly utilizing hyaluronan. Similar to hyaluronan, the carbomer molecule has bioadhesive and viscoelastic properties, and has been 15 studied for use in human medicine. Carbomers are generally inert biologically, non-irritating, and have been used in humans as injectable depots for time-release medications. Our objective was to describe the outcome of intra-articular viscosupplementation with carbomer in four horses. Four healthy adult mares participated in this study. Baseline lameness examinations, aseptic arthrocenteses and synovial fluid analyses were performed. Three mL of 3% carbomer was then 20 injected into each left middle carpal joint. Lameness evaluations were repeated daily for each horse for ten days post-injection or until the time of euthanasia. At euthanasia, synovial fluid analyses were repeated on the left middle carpal joint. Samples of synovium from the left middle carpal joints were submitted for histopathology. Articular cartilage of the third carpal bone including subchondral bone was submitted for histology and confocal microscopy. 25 Carbomer viscosupplementation of the middle carpal joint caused severe lameness in 3 /4 mares. The fourth mare developed moderate lameness after injection. Confocal microscopy was negative for cartilaginous defects. Histology of all treated samples revealed varying degrees of small cell inflammatory infiltrate into the subsynovia. With no abnormal findings in samples of cartilage or subchondral bone, lameness is attributable to 30 severe synovitis, which is consistent with histologic findings of synovium in all cases. The current formulation of carbomer is therefore not suitable for intra-articular viscosupplementation in horses.

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Animal Models for Eye Diseases and Therapeutics

Iwata

Tomarev

Sourcebook of Models for Biomedical Research

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Obstruction of Aqueous Humor Outflow by Cross-linked Polyacrylamide Microgels in Bovine, Monkey, and Human Eyes

Cited by 8 publications

References 7 publications

A comparison of Healon and Amvisc on the early postoperative pressure after extracapsular cataract extraction with implantation of posterior chamber lens

A comparison of Healon and Amvisc on the early postoperative pressure after extracapsular cataract extraction with implantation of posterior chamber lens

Carbomer Viscosupplementation in the Equine Middle Carpal Joint

Animal Models for Eye Diseases and Therapeutics

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