Animal Models for Eye Diseases and Therapeutics

Iwata, Takeshi; Tomarev, Stanislav I.

doi:10.1007/978-1-59745-285-4_31

Cited by 10 publications

(5 citation statements)

References 54 publications

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“…It is estimated that 80% of information from our environment is obtained through the eyes. (1,2) Thus, vision is indispensable for maintaining a quality of life. However, according to a report by the World Health Organization, approximately 36 million persons worldwide were blind in 2015, and the number is expected to increase to 115 million by 2050 owing to aging and population growth.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional-printed Refillable Drug Delivery Device for Long-term Sustained Drug Delivery to Retina

Hori¹,

Ito²,

Raut³

et al. 2023

Sensors and Materials

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As the aging population increases worldwide, the number of patients with retinal diseases requiring long-term treatment, such as for age-related macular degeneration (AMD), is expected to increase. Intravitreal injection is the most common clinical treatment method for AMD, but a less invasive method and continuous drug administration are desirable. Here, we report a 3D-printed refillable drug delivery system (DDS) that fits the curvature of the eyeball. This DDS has three parts: a drug injection port for drug reloading, a drug release port with an opening for unidirectional release into the sclera, and a drug tank for drug retention. We evaluated in vitro the sustained release of fluorescein isothiocyanate conjugate (FITC)-albumin used as a model drug from 20 wt% poly(vinyl alcohol) (PVA) hydrogel placed at the release port over 200 days. Furthermore, we showed that ten successive drug refills could be carried out without problems. Finally, a smaller version of the DDS was implanted in vivo in rabbit sclera, which showed sufficient fluorescence release in the retina and the choroid/RPE homogenate. The present DDS with drug reloading capacity shows excellent promise as a minimally invasive drug administration tool for the long-term treatment of retinal diseases.

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Section: Introductionmentioning

confidence: 99%

Three-dimensional-printed Refillable Drug Delivery Device for Long-term Sustained Drug Delivery to Retina

Hori¹,

Ito²,

Raut³

et al. 2023

Sensors and Materials

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“…Research using animal models in ophthalmology has enabled significant progress to be made in understanding the mechanisms of ocular diseases and in evaluating the efficacy of new therapeutic approaches [1]. However, commonly used models, such as mice, rats, and most of rodents, are not equivalent in terms of similarity to human vision and present major anatomical and functional differences [2].…”

Section: Introductionmentioning

confidence: 99%

Gerbil, Psammomys obesus, a human-like rodent model of eye research

Mbarek,

Hammami,

Achour

et al. 2023

Rodents and Their Role in Ecology, Medicine and Agriculture [Working Title]

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The purpose of this chapter is to illustrate the use of rodents other than mice and rats as relevant models of nutritionally human eye diseases. The sand rat or Psammomys obesus (P. obesus), is a desert rodent from the subfamily Gerbillinae, which has been widely used as an excellent animal model of diet-induced diabetes and metabolic syndrome. In previous studies, we showed that P. obesus develops type II diabetes when exposed to a high-calorie diet under laboratory conditions, resulting in diabetic retinopathy with similar visual disorders to that observed in humans. In this chapter, we will explore the notable similarities and differences between the human and rodent visual systems and the pertinence of using P. obesus as animal model of eye research. Retinal function, particularly that mediated by cone, will also be illustrated.

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“…However, in the creation of animal models, the similarity of the visual system and eye anatomy of the model with humans, the availability of animals, and the cost are considered as important criteria. Ruminant eye is seen as advantageous in terms of these criteria (Iwata & Tomarev, 2008). In terms of model use, the ruminant eye is also frequently preferred and so many studies have been conducted in both cattle and sheep-goat eyes (Coroneo, 1990; Iwata & Tomarev, 2008; Schnichels et al, 2019; Thompson, 2020; Alvites et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Ruminant eye is seen as advantageous in terms of these criteria (Iwata & Tomarev, 2008). In terms of model use, the ruminant eye is also frequently preferred and so many studies have been conducted in both cattle and sheep-goat eyes (Coroneo, 1990; Iwata & Tomarev, 2008; Schnichels et al, 2019; Thompson, 2020; Alvites et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Morphological Aspects and Microscopic Analyses of Fibrous Tunic and Uveal Components in Bovine Eye

Ertaş

Kahvecioğlu²,

Erdoğan

2022

Microscopy and Microanalysis

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This study aimed to reveal the anatomical features of the bovine eye by scanning electron and light microscopic methods. For this purpose, a total of 40 eyes were evaluated. Gross and microscopic characteristics of the cornea, sclera, ciliary body, choroid, iris, and lens were determined. Bowman's and Descemet's membranes of the cornea were quite dense and prominent. Collagen lamellae of the cornea were wavy in the periphery and more parallel to the basal and metachromatic fibroblasts were noted. Three to four ciliary plicae merged to form ciliary processes. The presence of prominent intermediate bands connecting the ciliary plicae was determined. The zonular fibrils merged and attached to the lens in the form of thick zonular bands. A dense corpora nigra was present at the rectangular pupillary border of the iris. Tapetum fibrosum, consisting of polygonal tapetal cells, was in blue-yellow-green color and covered most of the choroid. A complex drainage system consisting of trabecular meshwork, angular aqueous plexus, ciliary sinus, and scleral venous vessels localized in a fairly wide iridocorneal angle was identified. Identifying structural features of the bovine eye is very important and useful for pathological evaluations, understanding species-specific physiological mechanisms and for operative interventions of ruminant species.

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Animal Models for Eye Diseases and Therapeutics

Cited by 10 publications

References 54 publications

Three-dimensional-printed Refillable Drug Delivery Device for Long-term Sustained Drug Delivery to Retina

Three-dimensional-printed Refillable Drug Delivery Device for Long-term Sustained Drug Delivery to Retina

Gerbil, Psammomys obesus, a human-like rodent model of eye research

Morphological Aspects and Microscopic Analyses of Fibrous Tunic and Uveal Components in Bovine Eye

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