Obstetric outcomes after fresh versus frozen-thawed embryo transfers: A systematic
            review and meta-analysis

Roque, Matheus; Valle, Marcello; Sampaio, Marcos; Geber, Selmo

doi:10.5935/1518-0557.20180049

Cited by 35 publications

(33 citation statements)

References 57 publications

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“…In 2015, more than 51 000 infants were born using ART, accounting for approximately 5% of all live births in Japan. However, ART is associated with an increased risk of chromosomal abnormalities, small for gestational age (SGA) fetuses, preterm labor, hypertensive disorders of pregnancy (HDP), placenta previa, placental abruption, gestational diabetes and cesarean delivery …”

Section: Introductionmentioning

confidence: 99%

Embryo transfer associated with hormone replacement therapy cycles using assisted reproductive technology increases placenta accreta spectrum

Sakai

Ono

Iizuka

et al. 2019

J of Obstet and Gynaecol

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Aim: To evaluate obstetric outcomes in embryo transfer (ET) during estrogen with progestin hormone replacement therapy (HRT) cycles using assisted reproductive technology (ART). Methods: Of the 118 singleton pregnancies conceived with ART and delivered between January 2015 and December 2017, we reviewed the data of 87 cases that had information on HRT at the time of ET. Data on pregnancy outcomes included the presence of small for gestational age fetuses, hypertensive disorders of pregnancy, placenta previa (including low-lying placenta), placental abruption and placenta accreta spectrum (including placenta accreta, placenta increta and placenta percreta). We investigated the relationship between HRT cycles and adverse placental outcomes (placenta accreta spectrum, placental abruption, placenta previa, hypertensive disorders of pregnancy and small for gestational age fetuses). We then analyzed the associations that correlated with adverse placental outcomes. Results: Patients with ET during HRT cycles were more likely to have placenta accreta spectrum. During the study period, 87 out of 118 singleton live births using ART had information on HRT (60 HRT cycles and 27 ovulation cycles). The incidence of placenta accreta spectrum was significantly higher in the HRT cycle group than in the ovulation cycle group (HRT cycle, 31.7% [19 of 60] vs ovulation cycle, 7.4% [2 of 27]; P < 0.01). Conclusion: The obstetric outcomes occurring in pregnancies involving HRT use may differ among ET cycles. ET during HRT cycles were associated with adverse obstetric outcomes due to placenta accreta spectrum. The potential interaction between HRT cycles and adverse placental events is novel and warrants further investigation.

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Section: Introductionmentioning

confidence: 99%

Embryo transfer associated with hormone replacement therapy cycles using assisted reproductive technology increases placenta accreta spectrum

Sakai

Ono

Iizuka

et al. 2019

J of Obstet and Gynaecol

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“…A systematic review and meta-analysis on Obstetric outcomes after fresh versus frozen-thawed embryo Transfers searched 654 papers and showing that when comparing pregnancies that arose from FET or fresh embryo transfer, there was an increase in the risk of obstetric complications in pregnancies resulting from FET when compared to those emerging from fresh embryo transfers in PIH (aOR 1.82; 95% CI 1.24-2.68), pre-eclampsia (aOR 1.32, 95% CI 1.07, 1.63), and placenta accreta (aOR 3.51, 95% CI 2.04-6.05). 34 A retrospective cohort study compared the frequency of preeclampsia diagnosis for cryopreserved-warmed versus fresh ET in 15,937 births from ART found that Among pregnancies conceived with autologous eggs resulting in singletons, preeclampsia was greater after cryopreservedwarmed versus fresh ET (7.51% versus 4.29%, adjusted odds ratio = 2.17 [95% CI 1.67-2.82]) and among twin pregnancies, the frequency of preeclampsia with severe features (9.26% versus 5.70%) and preeclampsia with preterm delivery (14.81% versus 11.74%) was higher after cryopreserved versus fresh transfers. 35 In our study also gestational hypertension and preeclampsia were found more in Frozen ET group though statistically not significant.…”

Section: Discussionmentioning

confidence: 99%

Obstetric and perinatal outcomes in pregnancies occurring as a result of Fresh and Thawed frozen embryo transfer

Shah¹,

Jayakrishnan²

2019

Int J Reprod Contracept Obstet Gynecol

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Background: In vitro fertilization is a known independent risk factor for adverse perinatal outcomes. To explore obstetric and perinatal outcomes in pregnancies occurring as a result of fresh and thawed frozen embryo transfer.Methods: Retrospective observational study with 208 patients. A period of 2 years from October 2015 to October 2017. Tertiary care Fertility, Laparoscopy and research centre. All pregnancies conceived by IVF (n= 208) between the study period were included. The patients were grouped by fresh (n= 108) versus frozen (n= 100) embryo transfer. Patients conceived with donor embryo transfer were excluded. Primary outcomes were missed abortions, ectopic pregnancy, live births. Incidence singleton pregnancies and multiple gestations, preterm delivery, birth weight, an obstetric complication includes gestational hypertension, preeclampsia, gestational DM, placenta previa.Results: A total 208 patient analyzed who conceived with IVF treatments, among them 108 patients were in Fresh ET group and 100 were in Frozen ET group. The incidence of Ectopic Pregnancy was more in fresh ET as compared to Frozen ET (14.8%, 02% respectively, p value <0.05) whereas that of missed abortions were more in Frozen ET (22% versus 11.1%, p value 0.03). There were no significant differences in obstetric and perinatal outcomes in both groups.Conclusions: In this study of IVF pregnancies, adverse obstetric and neonatal outcomes did not differ between fresh and frozen embryo transfers. Literature tells that there may be an increased risk of preeclampsia and large for gestational age babies in pregnancies conceiving after frozen embryo transfer. So freeze all policy should be applied to only indicated cases and not to all because both the groups having similar outcomes.

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“…Недавний метаанализ, выполненный M. Roque и соавт. [18], посвящен акушерским осложнениям после переноса свежих и криоконсервированных эмбрионов. Из найденных 915 статей проанализированы 6, которые соответствовали критериям включения.…”

Section: акушерские осложненияunclassified

Reproductive and perinatal outcomes of a frozen embryo transfer in the programs of assisted reproductive technologies(literature review)

Melkozerova¹,

Башмакова²,

Dankova³

et al. 2019

Probl. reprod.

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ФГБУ «Уральский научно-исследовательский институт охраны материнства и младенчества» Минздрава России, Екатеринбург, Россия РЕЗЮМЕ В настоящем обзоре проанализированы данные литературы о репродуктивных и перинатальных исходах применения криотехнологий в программах экстракорпорального оплодотворения (ЭКО), рассмотрены акушерские осложнения. Для анализа использованы публикации баз данных PubMed, Medline, Crossref за 2012-2018 гг. Показано, что применение криотехнологий позволяет минимизировать риск развития синдрома гиперстимуляции яичников, преждевременной отслойки плаценты и преждевременных родов. Перинатальная смертность после процедуры переноса замороженных эмбрионов ниже, чем после переноса свежих эмбрионов. В то же время использование криоконсервированных эмбрионов статистически значимо чаще ассоциируется с развитием гипертензивных расстройств у беременных женщин и послеродовых кровотечений. Перенос криоконсервированных эмбрионов приводит к статистически значимо большей частоте рождения детей с макросомией и большой массой тела для гестационного возраста, что в свою очередь повышает риск мертворождения, гипоксии плода, операции кесарева сечения, послеродового кровотечения, дистоции плечиков, метаболических нарушений при рождении. Причины такой неоднородности в развитии тех или иных осложнений при использовании разных методов ЭКО окончательно не выяснены. Необходимо дальнейшее изучение данного вопроса для обоснования применения наиболее эффективного и безопасного метода ЭКО у каждой конкретной пациентки. Ключевые слова: перенос криоконсервированных эмбрионов, криотехнологии, перинатальные исходы, репродуктивные исходы, акушерские осложнения.

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Obstetric outcomes after fresh versus frozen-thawed embryo transfers: A systematic review and meta-analysis

Cited by 35 publications

References 57 publications

Embryo transfer associated with hormone replacement therapy cycles using assisted reproductive technology increases placenta accreta spectrum

Embryo transfer associated with hormone replacement therapy cycles using assisted reproductive technology increases placenta accreta spectrum

Obstetric and perinatal outcomes in pregnancies occurring as a result of Fresh and Thawed frozen embryo transfer

Reproductive and perinatal outcomes of a frozen embryo transfer in the programs of assisted reproductive technologies(literature review)

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