Observations on the mechanism of abdominal pain.

Holdstock, Douglas; Misiewicz, J. J.; Waller, Sheila L.

doi:10.1136/gut.10.1.19

Cited by 95 publications

(17 citation statements)

References 16 publications

(8 reference statements)

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“…Earlier research by Champion (2), Holdstock, Misiewicz, and Waller (3), and Wangel and Deller (4) atrributed IBS to increased colon motor activity whereas Snape (5) associated IBS with an abnormally high incidence of 2-4 cycles per minute (cpm) slow-wave activity in the resting sigmoid colon. Recently, research indicates that the colonic response to environmental stimuli may be a sensitive measure of physiologic change in normals.…”

mentioning

confidence: 97%

The Effect of Stress on Colon Motor and Electrical Activity in Irritable Bowel Syndrome

Welgan

Meshkinpour

Hoehler

1985

Psychosomatic Medicine

128

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The present investigation was designed to study the role of stress on the physiologic mechanisms of the colon in irritable bowel syndrome (IBS). Patients with IBS were compared with normal controls during resting and stress (mental arithmetic, cold pressor, and fear stressor). The results indicated that IBS patients had significantly higher motor activity than normals in the resting state but did not differ from them in the mean dominant frequency of the basal electrical rhythm (BER) or the proportion of the time they had 2-4 cycles per minute (cpm) slow-wave activity. Stress significantly increased motor activity in both groups although they did not differ significantly from each other during stress. Stress increased the proportion of 2-4 cpm slow-wave activity in IBS patients, but decreased in the controls. The type of stressor, however, did not influence either motor or electrical activity. Although IBS patients were significantly older than the controls and scored higher on the MMPI scales of Hypochondriasis, Hysteria, and Depression, these factors did not significantly influence differences in motor or electrical activity between the groups. The results are discussed in terms of the role of learning in the colon.

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mentioning

confidence: 97%

The Effect of Stress on Colon Motor and Electrical Activity in Irritable Bowel Syndrome

Welgan

Meshkinpour

Hoehler

1985

Psychosomatic Medicine

128

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“…The relationship of irritable bowel syndrome (particularly abdominal pain) to disordered colonic motility has never been conclusively established although both food-stimulated hypermotility and distension of the colon have been shown to be associated with the onset of the typical symptoms (Connell et al, 1965;Holdstock et al, 1969;Swarbrick et al, 1980). Anticholinergic compounds have long been used in the treatment of irritable bowel syndrome.…”

Section: Introductionmentioning

confidence: 99%

The effect of secoverine hydrochloride on stimulated sigmoid motility: a double‐blind, placebo controlled cross‐over study in irritable bowel syndrome.

Ehsanullah¹,

Lee²,

Williams³

et al. 1985

Brit J Clinical Pharma

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The effect of oral secoverine hydrochloride on neostigmine‐stimulated sigmoid motility in 12 patients with irritable bowel syndrome was studied in a double‐blind placebo‐controlled cross‐over study. Both spontaneous and stimulated motor activity were significantly reduced by the compound in comparison with placebo. The most sensitive indices were the frequency of wave activity, maximum amplitude and motility index. Two patients reported mild dizziness after secoverine.

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“…It has been sug gested [7] that fiber-deficient diets may be important in producing IBS in industrialized countries, but there is conflicting evidence for [8][9][10] and against [11][12][13] the therapeutic benefits of bran or other bulking substances. Cramping abdominal pain in patients with IBS has been demonstrated to coincide with either small bowel or colon hypermotility [14,15] and it is generally supposed that IBS constitutes a disorder of motility [16], This possible motility defect is the basis for the application of antispasmodic drugs, such as mebeverine, which has been shown to dimin ish motility and intraluminal pressures in the bowel [17], The aim of the present study was to evaluate in patients with IBS the thera peutic effect of wheat bran in an open study and that of mebeverine in a double-blind study.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Therapeutic Effect of Wheat Bran, Mebeverine and Placebo in Patients with the Irritable Bowel Syndrome

Kruis¹,

Weinzierl²,

Schüssler³

et al. 1986

Digestion

104

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There is no generally accepted treatment in the irritable bowel syndrome (IBS), probably because of a lack of convincing therapeutic trials. In the present study, 120 outpatients with IBS participated in a prospective randomized therapeutic trial. According to a double-blind design, 40 patients received 400 mg/day mebeverine and 40 patients received a placebo. In an open branch of the trial, 40 patients were treated with 15 g/day wheat bran. The effects of treatment on symptoms were noted after 4, 8, 12 and 16 weeks of therapy. A significantly superior symptomatic effect of bran in comparison to mebeverine and placebo was demonstrated after 12 weeks, but could not be confirmed at the end of the study. There was no significant difference between the symptomatic effect of mebeverine and placebo. The compliance with the therapy was about 80% for 4 weeks, but dropped to about 50% at the end of the trial. This points to a particular difficulty in the management of patients with IBS. The results of this trial suggest that bran and mebeverine are no ideal therapy for patients with IBS but they support the therapeutic use of bran in patients with IBS.

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Observations on the mechanism of abdominal pain.

Cited by 95 publications

References 16 publications

The Effect of Stress on Colon Motor and Electrical Activity in Irritable Bowel Syndrome

The Effect of Stress on Colon Motor and Electrical Activity in Irritable Bowel Syndrome

The effect of secoverine hydrochloride on stimulated sigmoid motility: a double‐blind, placebo controlled cross‐over study in irritable bowel syndrome.

Comparison of the Therapeutic Effect of Wheat Bran, Mebeverine and Placebo in Patients with the Irritable Bowel Syndrome

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