The Effect of Stress on Colon Motor and Electrical Activity in Irritable Bowel Syndrome

Welgan, Peter R.; Meshkinpour, Hooshang; Hoehler, Fred K.

doi:10.1097/00006842-198503000-00005

Cited by 128 publications

(58 citation statements)

References 8 publications

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“…In the current study, MS180 rats showed increased fecal pellet output in response to WA, as well as following exposure to a novel environment, compared with control NH animals. These findings are consistent with Valentino's model and parallel reports of increased sigmoid motility in response to emotional stressors in IBS patients (74).…”

Section: Face Validity Of the Modelsupporting

confidence: 91%

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Coutinho¹,

Plotsky

Sablad³

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

400

372

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Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol 282: G307-G316, 2002. First published October 3, 2001 10.1152/ajpgi.00240.2001.-This study investigated the combined effect of neonatal maternal separation and acute psychological stress on pain responses in adult rats. Long-Evans dams and their male pups were reared under two conditions: 1) 180 min daily maternal separation (MS180) on postnatal days 2-14 or 2) no handling or separation (NH). At 2 mo of age, visceromotor responses to graded intensities of phasic colorectal distension (10-80 mmHg) at baseline as well as following acute 60 min water avoidance stress (WA) were significantly higher in MS180 rats. Both groups showed similar stress-induced visceral hyperalgesia in the presence of naloxone (20 mg/kg ip). MS180 rats had smaller stress-induced cutaneous analgesia in the tail-flick test compared with NH rats, with a residual naloxone-resistant component. MS180 rats showed an enhanced fecal pellet output following WA or exposure to a novel environment. These data suggest that early life events predispose adult Long-Evans rats to develop visceral hyperalgesia, reduced somatic analgesia, and increased colonic motility in response to an acute psychological stressor, mimicking the cardinal features of irritable bowel syndrome. irritable bowel syndrome; stress; analgesia; naloxone IRRITABLE BOWEL SYNDROME (IBS) is a disorder characterized by chronic abdominal pain and discomfort associated with alterations in bowel habits in the absence of a demonstrable pathology (67). Although IBS is likely a heterogeneous disorder in terms of etiology and pathophysiology, alterations in bowel habits are likely related to alterations in autonomic regulation of the gut, whereas symptoms of abdominal pain and discomfort are thought to involve additional changes in the perception of visceral events, in the form of visceral hyperalgesia or allodynia (46, 48). Additionally, in IBS patients without a concurrent diagnosis of fibromyalgia, visceral hypersensitivity is associated with a normal or diminished somatic pain sensitivity to noxious stimuli (13).Progress in the development of more effective therapies has been hampered due to the lack of animal models that mimic the key features of IBS, in particular the enhanced perception of visceral events. Many investigations have utilized acute inflammatory insults to the gut using agents such as glycerol, mustard oil, acetic acid, or zymosan to produce acute visceral hypersensitivity, thereby mimicking inflammatory bowel disorders. However, IBS is a chronic disorder characterized by the absence of inflammatory changes in the gut mucosa. More recently, several potential IBS models have been reported, all of which mimic certain aspects of the human syndrome (2, 15, 62, 72). They include an early life colon irritation model (2), an adult stress sensitization model (62), and an adult postinfection model in the rat (15) and in the mouse (72). Alt...

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Section: Face Validity Of the Modelsupporting

confidence: 91%

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Coutinho¹,

Plotsky

Sablad³

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

400

372

View full text Add to dashboard Cite

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“…However, none has proved this phenomenon statistically. Some authors reported that colonic motility showed no significant difference between the IBS patients and controls in response to the stress (Latimer et al 1981;Narducci et al 1985 ;Welgan et al 1985). Discrepancy between these outcomes and ours cannot be explained on the same basis because they have different features ; subject selection, method of bowel preparation, the recording site, the recording device, and method of data analysis.…”

Section: Discussionmentioning

confidence: 60%

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

Fukudo

Suzuki

1987

Tohoku J. Exp. Med.

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“…In addition, stress sensitivity may be different from person to person. As for human subjects, it has been reported that psychological stress induced an increase in colonic activity (Naruducci et al, 1985;Rao et al, 1998;Welgan et al, 1985;Welgan et al, 1988). MDT-stress, in particular, induced a significant increase in the colonic motility of patients with irritable bowel syndrome, with an increase in heart rate variability, but not in healthy controls (Fukudo and Suzuki, 1987).…”

Section: Correlation Of Both Anxiety and Depression Scores And The Lfmentioning

confidence: 99%

Correlations between the responses of electrogastrograms, heart rate and respiratory rate to the stress of the mirror drawing test in human subjects

Homma

2006

J. Smooth Muscle Res.

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Original C o r r e l a t i o n s b e t w e e n t h e r e s p o n s e s o felectrogastrograms, heart rate and respiratory rate to the stress of the mirror drawing test in human subjects AbstractAn electrogastrogram (EGG) recorded on the skin is believed to reflect the electrical activity of the gastrointestinal tract. In this study, linear correlations were calculated for the EGG spectral frequencies and the power ratios, changes in heart and respiratory rate before and during mirror drawing test (MDT) stress and after having meals, with the changes in the sympathetic tone indicator (LF/HF) and HADS anxiety and depression scores in human subjects (n=48). Depression scores had a negative linear correlation with the EGG resting frequencies of the epigastric and supraumbilical 6 cpm groups (5.0-7.4 cpm). Anxiety scores had a positive linear correlation with the EGG area power ratio of the resting to MDT stress responses of the epigastric and infraumbilical 6 cpm groups (6 cpm area during MDT/that during fasting rest). The resting LF/HF had a positive linear correlation with the EGG area power ratio of the resting to MDT stress responses of the epigastric and infraumbilical 3 cpm groups (2.5-4.9 cpm). The resting LF/HF ratio had a negative correlation with the area power ratio of the resting to postprandial responses (postprandial power/resting power) in the epigatric, supraumbilical and infraumbilical 6 cpm groups. The resting LF/HF ratio had a positive linear correlation with the heart rate at rest and during MDT-stress. In contrast, the resting LF/HF ratio had a negative linear correlation with the respiratory rate at rest and during MDT-stress. EGGs of the surface electrical activities of the gastrointestinal tract were influenced by acute MDT-stress and their frequencies and their response power ratios were correlated linearly with anxiety scores, depression scores and the sympathetic tone indicator, the LF/HF ratio.

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The Effect of Stress on Colon Motor and Electrical Activity in Irritable Bowel Syndrome

Cited by 128 publications

References 8 publications

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

Correlations between the responses of electrogastrograms, heart rate and respiratory rate to the stress of the mirror drawing test in human subjects

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