“…The anticholiner gics, clidinium. secoverine and cimetropium, acutely inhibit postprandial colonic motility [63][64][65], Oral hyoscine improved symptoms, but required combination with fiber and a tranquilizer to exceed the response to placebo [59], However, the anticholinergic, profinium, significantly improved the global symp toms which combined evaluation of abdomi nal pain, flatulence, and an altered bowel hab it [62], There has been evaluation of other drugs that are believed to be antispasmodic, but their exact mode of action is still unclear. Mcbcvcrinc is a phcnylethylamine derivative of reserpine which is believed to relax smooth muscle without anticholinergic side effects.…”