Role of Colonic Motility in Guiding Therapy in Patients with Constipation

Wj, Snape

doi:10.1159/000171625

Cited by 23 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, antispasmodics may decrease the functional obstruction caused by increased phasic colonic contractions that may be present in constipation. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of drotaverine hydrochloride in irritable bowel syndrome: A randomized double-blind placebo-controlled study

Ramesh

Dwivedi

Kumar

2014

Saudi J Gastroenterol

View full text Add to dashboard Cite

Backgrounds/Aims:To study the efficacy and safety of drotaverine hydrochloride (HCl) 80 mg tablet given thrice a day in the symptomatic relief of patients with irritable bowel syndrome (IBS).Patients and Methods:The study was a multicentric, randomized, double-blind, placebo-controlled parallel group study performed at three centers. The patients who fulfilled Rome II Criteria of IBS were included in the study. A total of 180 patients with IBS were randomized to drotaverine and placebo treatment groups. Abdominal pain and stool frequency were measured every week in both the groups for all the 4 weeks of treatment duration. Subject Global Assessment of Relief (SGA) of IBS symptoms was assessed at the end of the study. Appropriate statistical analysis was done using SPSS software.Statistical Analysis Used:Mann–Whitney U-test (two-tailed), Wilcoxon signed ranks test, and McNemar tests.Results:Pain frequency decreased significantly (P < 0.01) in 22 (25.9%), 51 (60%), and 66 (77.7%) patients in the drotaverine group, at the end of 2nd, 3rd, and 4th weeks, respectively, as compared with 8 (9.4%), 18 (21.2%), and 26 (30.6%) in the placebo group. Pain severity scores also decreased significantly in the drotaverine group 66 (77.7%) as compared with placebo 26 (30.6%) after 4 weeks. Drotaverine HCl was shown to provide significant improvement (P < 0.01) in global relief in abdominal pain as perceived by the patient (85.9% vs 39.5%) and the clinician (82.4% vs 36.5%) in the drotaverine group as compared with placebo. There is significant (P < 0.01) improvement in stool frequency in drotaverine HCl treatment group as compared with placebo. The drug is well tolerated without any major side effects.Conclusions:A 4-week treatment with drotaverine significantly improves abdominal symptoms in patients with IBS.

show abstract

“…In fact, antispasmodics may decrease the functional obstruction caused by increased phasic colonic contractions that may be present in constipation. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of drotaverine hydrochloride in irritable bowel syndrome: A randomized double-blind placebo-controlled study

Ramesh

Dwivedi

Kumar

2014

Saudi J Gastroenterol

View full text Add to dashboard Cite

show abstract

Colonic transit studies: normal values for adults and children with comparison of radiological and scintigraphic methods

et al. 2009

View full text Add to dashboard Cite

The sitz or plastic marker study for colonic transit has been around for many years. It is applicable where an X-ray machine exists, is widely used and is accepted as the gold standard for diagnosing constipation. Recently, radiopharmaceutical methods have been developed. The theme of this review is their possible roles in the assessment of paediatric bowel motility disorders in patients presenting to paediatric surgeons. This review presents data on total and segmental transit in normal adults and children and comparing the two techniques in adults. Reliability and reproducibility are presented. Normative data for colonic transit in adults and children are discussed and parameters for assessing abnormal transit are reviewed. Normal colonic transit takes 20-56 h. Plastic marker studies are more readily accessible, but the assessment may be misleading with current methods. Plastic markers show faster transit than scintigraphy. It is difficult to compare the two techniques because methods of reporting are different. Using scintigraphy, repeatability is good. Separation of normal from slow transit in the ascending colon is apparent at 24 and 48 h, but the determination of transit through the distal colon/rectum in adults may require studies of more than 7 days. In conclusion, plastic marker studies and scintigraphy show similar transit rates in young adults and children. However, scintigraphy has advantages of allowing transit through the stomach and small intestine to be measured and has proved useful in the diagnostic workup of children with intractable constipation.

show abstract

Electrodiagnosis of the anorectum: a review of techniques and clinical applications

Podnar

2003

Techniques in Coloproctology

View full text Add to dashboard Cite

Electrodiagnostic tests may be valuable in the assessment of patients with anorectal dysfunction and are complementary to imaging and manometry. While the latter delineate morphological and functional sphincter changes, respectively, electrodiagnostic methods document, help to localize and assess the severity and mechanism of neural injury. These data are important for the treatment of patients and for estimating their prognoses. Among electrodiagnostic tests, concentric needle electromyography of the external anal sphincter is the most important. It demonstrates muscle denervation, quantitatively estimates muscle reinnervation, estimates the level of motor neuron excitability and assesses several kinesiological parameters. In addition, measurement of the bulbocavernosus reflex is often useful, while pudendal somatosensory evoked potentials are sometimes useful. Use of single tests of sacral nervous system by workers less familiar with theoretical principles of clinical neurophysiology is discouraged. In patients with suspected neurogenic bowel disorders, comprehensive electrodiagnostic approach, performed by clinical neurophysiologists experienced in application of these tests to the sacral nervous system, should complement data obtained by other methods and guide patient management.

show abstract

Role of Colonic Motility in Guiding Therapy in Patients with Constipation

Cited by 23 publications

References 47 publications

Efficacy and safety of drotaverine hydrochloride in irritable bowel syndrome: A randomized double-blind placebo-controlled study

Efficacy and safety of drotaverine hydrochloride in irritable bowel syndrome: A randomized double-blind placebo-controlled study

Colonic transit studies: normal values for adults and children with comparison of radiological and scintigraphic methods

Electrodiagnosis of the anorectum: a review of techniques and clinical applications

Contact Info

Product

Resources

About