Observations on the histology of the gastric mucosa in chronic gastric ulcer

Thomas, Eapen; Hall, Peter; Hislop, I. G.

doi:10.1007/bf02231635

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…Thus, certain inferences may be drawn from this study which has been unable to demonstrate any effect of carbenoxolone upon the histology of the gastric mucosa either during or after the process of ulcer repair. This supports our previous conclusions (Thomas et al, 1972) that the relationship between gastritis and gastric ulcer is uncertain, for the morphological changes in the gastric mucosa persist unaltered even under the influence of a drug which has been shown to promote healing (Doll et al, 1965;Horwich and Galloway, 1965).…”

Section: Discussionsupporting

confidence: 91%

“…Gastritis has been shown to occur in association with gastric ulcers (Ball and James, 1961;DuPlessis, 1965) and its persistence has been demonstrated both during and after healing of the ulcer (Palmer, 1951;Salupere, 1969;Thomas et al, 1972). Goodier (1968) carried out a histological study on the gastrectomy specimens of 16 gastric ulcer patients treated with carbenoxolone.…”

Section: Discussionmentioning

confidence: 99%

“…Histological interpretation of the type of chronic gastritis and degree of cellular infiltration was assessed 'blind' as described previously (Thomas et al, 1972). Thus, the pathologist (P.H.)…”

Section: Methodsmentioning

confidence: 99%

“…This study was conducted to investigate whether the drug altered the morphological appearances which have been demonstrated in the gastric mucosa in association with chronic gastric ulcer (Magnus, 1952;Mackay and Hislop, 1966;Thomas, Hall, and Hislop, 1972).…”

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confidence: 99%

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Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone

Thomas¹,

Hall²,

Hislop³

1973

Gut

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SUMMARY Serial direct vision gastric mucosal biopsies were obtained in 25 patients with a chronic lesser curve gastric ulcer. Morphological changes were assessed 'blind' in 15 patients who received carbenoxolone and in 10 untreated patients.Chronic gastritis was initially observed 'proximal' and 'distal' to the ulcer in 24 of the 25 patients. The mucosal changes were shown to persist in subsequent biopsies and appeared to be uninfluenced by therapy with carbenoxolone even when the ulcer had healed.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone

Thomas¹,

Hall²,

Hislop³

1973

Gut

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“…Many subjects without an ulcer have signs of intestinal metaplasia (NUPIP) and many gastric ulcer patients do not have intestinal metaplasia (GUNIP). [11][12][13] In addition, the observation at one time of intestinal metaplasia does not allow any conclusions to be drawn about any progression of this lesion in the future (P-IP or S (stable)-IP? ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Kuipers

1998

Aliment Pharmacol Ther

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Parietal cell antibodies part I. Clinical and pathological studies of parietal cell antibodies

Kogawa

1975

Gastroenterol Jpn

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The incidence of parietal cell antibodies (P.C.A.) in patients with various diseases was investigated by complement fixation test (C.F.T.). The relationship between the incidence of P.C.A. and clinical and pathological findings was also investigated. The incidence of P.C.A. with simple atrophic gastritis was 34.8% in total cases, 29.0% in male and 48.1% in female, respectively. The difference between the sexes was statistically significant (p less than 0.05). The incidence of P.C.A. in superficial gastritis was 37.5%, showing the same incidence as atrophic gastritis. The difference between the two groups was not statistically significant (p less than 0.05). The incidence in patients with hypo- and hyperactivity was 43.0% and 11.8%, respectively. The difference was statistically significant, but that between hypo- and normoacidity was not significant (p less than 0.05). The author postulated the conclusion that the superficial gastritis could be included in the category of atrophic gastritis. The dissociation of correlation of titer of C.F.T. with acidity and histological findings was found. The correlation was more significantly observed with acidity than with histological findings. The relatively high incidences of P.C.A. were noted in patients with peptic ulcer, gastric carcinoma and chronic thyroiditis. The incidence of P.C.A. in other diseases showed the nearly equal incidence to that of other investigators. Three cases of postgastrectomy patients were noted, in which the P.C.A. disappeared four to six months after total or subtotal gastrectomy.

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Observations on the histology of the gastric mucosa in chronic gastric ulcer

Cited by 11 publications

References 12 publications

Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone

Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Parietal cell antibodies part I. Clinical and pathological studies of parietal cell antibodies

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