Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone

Thomas, Eapen; Hall, Peter; Hislop, I. G.

doi:10.1136/gut.14.7.552

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Even if this were possible gastritis has a patchy distribution making comparisons even at specific sites unreliable. What is more, previous studies have also shown a poor correlation between endoscopic appearances and histological changes in patients with gastritis before operation (Morrissey, 1972;Thomas, Hall, and Hislop, 1973).…”

Section: Discussionmentioning

confidence: 95%

Duodenogastric reflux: a cause of gastric mucosal hyperaemia and symptoms after operations for peptic ulceration.

Keighley¹,

Asquith²,

Alexander-Williams³

1975

Gut

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SUMMARY This study has investigated the possible association between duodenogastric reflux, gastritis, and symptoms in 35 patients with or without dyspepsia one to 15 years after gastric surgery. Five patients were excluded because of biliary disease, hiatus hernia, or recurrent ulceration. The remaining 30 were assessed by a symptomatic score, measurement of bilirubin and sodium concentrations in samples of fasting gastric juice, endoscopy, gastric biopsy, and the presence of radiological reflux. In 15 patients with a symptom score of less than the median, gastric bilirubin levels were less than 1 mg/100 ml in 80%; severe endoscopic changes were seen in only one patient and reflux was not observed. In contrast, in patients with a symptom score in excess of the median fluoroscopic and biochemical reflux was seen in 69 and 80% respectively and severe mucosal hyperaemia in half. There was a significant correlation between symptoms, gastric hyperaemia, and duodenal reflux (P < 0-02).After gastric operations there are a number of patients with continued dyspepsia in whom there is no evidence of recurrent peptic ulceration. Although a proportion of these individuals have biliary disease or gastrooesophageal reflux there are a substantial number who do not. In many of the latter, there is endoscopic evidence of gastric mucosal hyperaemia associated with the presence of bile in the stomach and it has been suggested that gastritis associated with duodenal reflux is a cause of their symptoms (DuPlessis, 1962).Because the results of further gastric surgery in patients who do not have a recurrent ulcer are particularly disappointing (Halpern, Hirschowitz, and Moody, 1973) it is important to establish the cause of continued dyspepsia. It could be argued that one of the reasons for the poor results of re-operating on these patients is that symptoms are related to duodenal reflux. However, it is also possible that regurgitation of bile-stained juice and gastric mucosal hyperaemia are coincidental findings, unrelated to the presence of symptoms. In order to investigate this problem, an attempt has been made to examine the relationship between duodenogastric "This work was presented in part at the spring meeting of the British Society of Gastroenterology, Nottingham, 1974. Reprint requests to: Mr J. Alexander-Williams.Received for publication 26 September 1974. reflux, gastritis, and dyspepsia in 35 subjects seen one to 15 years after ulcer surgery. Patients and MethodsThe clinical material for this study was provided from two sources. There were 17 patients who were referred because of recurrent dyspepsia after previous gastric surgery and 18 who had replied to a postal questionnaire. The latter were selected because of their willingness to attend hospital for investigation and because analysis of their replies showed that they had no complaints. A preliminary barium meal and cholecystogram was performed on all patients. Following this, three individuals were excluded because of gallstones or hiatus hernia whilst two more w...

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Section: Discussionmentioning

confidence: 95%

Duodenogastric reflux: a cause of gastric mucosal hyperaemia and symptoms after operations for peptic ulceration.

Keighley¹,

Asquith²,

Alexander-Williams³

1975

Gut

View full text Add to dashboard Cite

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“…The incidence of histological evidence of gastritis was higher in all 3 groups. This difference is not unexpected, as it has previously been shown that there is a poor correlation between endoscopic appearances and histological changes before operation [16]. As the degree of gastritis was unchanged after treatment by highly selective vagotomy, a similar lack of correlation may also be expected in these patients.…”

Section: Discussionmentioning

confidence: 55%

Bile reflux and degree of gastritis after highly selective vagotomy, truncal vagotomy, and partial gastrectomy for duodenal ulcer

Johnston

1983

World j. surg.

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Enterogastric reflux of bile has been shown to be associated with chronic gastritis. We have investigated preoperative duodenal ulcer patients and patients treated by highly selective vagotomy, Polya partial gastrectomy, truncal vagotomy and pyloroplasty, and truncal vagotomy and gastrojejunostomy to assess the incidence of endoscopically observed bile reflux and gastritis, and to quantitate the degree of reflux of bile acids and histologically proven gastritis. The correlation between observed and proven gastritis was poor when the observed incidence of bile reflux was low (preoperative duodenal ulcer, highly selective vagotomy) but was good when the observed reflux was high (partial gastrectomy, truncal vagotomy, and drainage). Bile acid concentrations in the stomach were significantly lower after highly selective vagotomy than in preoperative patients and those treated by partial gastrectomy and truncal vagotomy and drainage. The antritis and body gastritis found before operation did not improve after highly selective vagotomy, but antritis showed a tendency to worsen after partial gastrectomy and truncal vagotomy and drainage. Body gastritis after highly selective vagotomy was significantly less (P < 0.001) than after partial gastrectomy and less than after truncal vagotomy and gastrojejunostomy and truncal vagotomy and pyloroplasty. The beneficial effects of highly selective vagotomy in the treatment of duodenal ulcer may be enhanced in the long term by reduction of enterogastric reflux and postoperative gastritis.

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On the role of inertial effects and dipole-dipole coupling in the theory of the Debye and far-infrared absorption of polar fluids. II. Comparison with experimental observations

Coffey

Corcoran

Vij

1987

Proc. R. Soc. Lond. A

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A general two-friction itinerant-oscillator model is given for molecular motion in dipolar fluids. The polarizability and relevant time-correlation functions are calculated by numerical methods. It is shown how the results of an earlier paper are obtained when the two frictions per unit inertia are equal. The model is compared with recent experimental measurements on hexanone-2 and acetonitrile obtained by using a new quasi-optical technique for frequencies intermediate between the MW and FIR spectral regions. This technique is described briefly; in particular, for a reasonable fitting of the theory to experiment the moment of inertia of the outer cage of molecules is always greater than that of the inner dipole in agreement with the original concept, namely a cage of dipoles surrounding a typical dipole. This is at variance with the earlier concept of the model where the friction on the encaged dipole is zero. There, for a good fit to experiment, the moment of inertia of the cage is always less than that of the dipole. This suggests that the two friction version should be used for such comparison. An analytical formula (analogous to the Rocard equation) for the polarizability derived earlier is shown to agree well with the result of numerical Fourier transformation of the response function. A distinct harmonic peak structure is noted in the FIR region of the spectrum when friction does not act on the inner dipole. The structure is damped out as this friction is increased. Thus only the first harmonic peak is significant when the frictions per unit inertia are approximately equal. Measurements in the frequency region (the intermediate region) lying between the microwave and the FIR for hexanone-2 in dilute solutions of cyclohexane are reported. These show a significant excess absorption over that predicted by the model in this region. It is suggested that the excess absorption arises from jumping of dipoles from well to well of the cosine potential of dipole-dipole interaction indicating that the effects of finite potential well depth must be incorporated in the model to explain the intermediate frequency absorption.

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Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone

Cited by 4 publications

References 10 publications

Duodenogastric reflux: a cause of gastric mucosal hyperaemia and symptoms after operations for peptic ulceration.

Duodenogastric reflux: a cause of gastric mucosal hyperaemia and symptoms after operations for peptic ulceration.

Bile reflux and degree of gastritis after highly selective vagotomy, truncal vagotomy, and partial gastrectomy for duodenal ulcer

On the role of inertial effects and dipole-dipole coupling in the theory of the Debye and far-infrared absorption of polar fluids. II. Comparison with experimental observations

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