Relationship between <i>Helicobacter pylori</i>, atrophic gastritis and gastric cancer

Kuipers, E.J.

doi:10.1111/j.1365-2036.1998.00009.x

Cited by 99 publications

(69 citation statements)

References 53 publications

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“…It is well known that there is a wide geographic difference in serum pepsinogen levels and in the prevalence of gastric atrophy [11,19]. Gastric atrophy has a stronger association with intestinal-type than with diffuse-type gastric carcinoma [5,19]. In our study, most of the cancers were poorly differentiated.…”

Section: Discussionmentioning

confidence: 58%

“…In Japan, however, over 90% of gastric cancer patients have evidence of atrophic gastritis [18]. It is well known that there is a wide geographic difference in serum pepsinogen levels and in the prevalence of gastric atrophy [11,19]. Gastric atrophy has a stronger association with intestinal-type than with diffuse-type gastric carcinoma [5,19].…”

Section: Discussionmentioning

confidence: 99%

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Serum pepsinogen levels in gastric cancer patients and their relationship with Helicobacter pylori infection: a prospective study

Yeoh

Moochala

et al. 2002

Gastric Cancer

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Serum pepsinogen levels in gastric cancer patients and their relationship with Helicobacter pylori infection: a prospective study

Yeoh

Moochala

et al. 2002

Gastric Cancer

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“…Intestinal histopathology has been associated with MSI (Ottini et al, 1997). Studies have also shown a correlation between H. pylori infection and intestinal-type gastric cancer (Driessen et al, 1999;Kuipers, 1998;Wu et al, 1997). Thus, it is possible that H. pylori predisposes to hMLH1 hypermethylation and MMR de®ciency.…”

Section: Discussionmentioning

confidence: 99%

Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia

Esteller²,

et al. 2001

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A signi®cant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with hypermethylation of the human mut-L homologue 1 (hMLH1) mismatch repair gene promoter and diminished hMLH1 expression in advanced gastric cancers. However, the relationship between MSI and hMLH1 hypermethylation has not been studied in early gastric neoplasms. We therefore investigated hMLH1 hypermethylation, hMLH1 expression and MSI in a group of early gastric cancers and gastric adenomas. Sixty-four early gastric neoplasms were evaluated, comprising 28 adenomas, 18 mucosal carcinomas, and 18 carcinomas with super®cial submucosal invasion but clear margins. MSI was evaluated using multiplex uorescent PCR to amplify loci D2S123, D5S346, D17S250, BAT 25 and BAT 26. Methylation-speci®c PCR was performed to determine the methylation status of hMLH1. In two hypermethylated MSI-H cancers, hMLH1 protein expression was also evaluated by immunohistochemistry. Six of sixty-four early gastric lesions were MSI-H, comprising 1 adenoma, 4 mucosal carcinomas, and 1 carcinoma with super®cial submucosal invasion. Two lesions (one adenoma and one mucosal carcinoma) demonstrated low-frequency MSI (MSI-L). The remaining 56 neoplasms were MSI-stable (MSI-S). Six of six MSI-H, one of two MSI-L, and none of thirty MSI-S lesions showed hMLH1 hypermethylation (P50.001). Diminished hMLH1 protein expression was demonstrated by immunohistochemistry in two of two MSI-H hypermethylated lesions. hMLH1 promoter hypermethylation is signi®cantly associated with MSI and diminished hMLH1 expression in early gastric neoplasms. MSI and hypermethylation-associated inactivation of hMLH1 are more prevalent in early gastric cancers than in gastric adenomas. Thus, hypermethylation-associated inactivation of the hMLH1 gene can occur early in gastric carcinogenesis. Oncogene (2001) 20, 329 ± 335.

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“…Our study showed a significant positive relationship between H. pylori infection and the risk of gastric diseases (p-value < 0.0001). [23][24][25][26]. The study of Graham [27] reported that at least 80% of patients with gastric cancer were infected by H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

Bounder¹,

Boura²,

SalouaNadifiyine³

et al. 2017

JLS

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Abstract:Helicobacter pylori (H. pylori) colonize the gastric mucosa of 50% of the world's population. This infection is closely associated with the development of peptic ulcer disease and gastric cancer. The present study was conducted to assess the prevalence of H. pylori infection in Moroccan population and the risk to develop gastric precancerous lesions and gastric cancer. Totally, 298 patients were enrolled, 68 of asymptomatic subjects and 230 of patients with gastric diseases. Histological examination was effected to diagnostic gastric lesions and to detect H. pylori. ELISA was used to determine H. pylori status of patients. The prevalence of H. pylori within asymptomatic and symptomatic subjects was observed higher. A significant relationship was detected between H. pylori infection and the risk of gastric diseases (p-value < 0.0001). A meaningful association between chronic gastritis increasing and age was observed (p-value = 0.03). The risk to develop gastric cancer among infected patients was observed elevated with rate of 9%. Our results showed a high prevalence of H. pylori in both asymptomatic and gastric diseases patients. We noticed that chronic gastric infection increases with age. We remarked also that the risk to develop gastric cancer among infected patients was elevated in our population.

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Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Cited by 99 publications

References 53 publications

Serum pepsinogen levels in gastric cancer patients and their relationship with Helicobacter pylori infection: a prospective study

Serum pepsinogen levels in gastric cancer patients and their relationship with Helicobacter pylori infection: a prospective study

Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

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