Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis

Chai, Jiake; Menghebat,; Wei, Jiao; Sun, Daoyuan; Bin, Liang; Shi, Jincao; Fu, Changhong; Xiong, Lei; Yiding, Mao; Wang, Xiuling; Dolikun,; Guliber,; Wang, Yanchun; Fanghua, Gao; Shuhua, Xiao

doi:10.1016/j.parint.2003.09.015

Cited by 45 publications

(25 citation statements)

References 10 publications

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“…In addition, novel formulations of benzimidazoles, either as pro-drugs (Walchshofer et al 1990), liposome-entrapped compounds (Wen et al 1996) or colloidal, intravenously injectable formulations (Rodrigues et al 1995) were tested in rodents and showed enhanced efficacy at lower doses than the parental compounds. However, these studies have not yet been translated into clinical applications, with one exception : Chai et al (2004) reported on improved efficacy of ABZ emulsion compared with ABZ tablets or capsules for the treatment of liver CE.…”

Section: I M I T a T I O N S O F C U R R E N T C H E M O T H E R A mentioning

confidence: 99%

Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis

et al. 2007

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Echinococcus granulosus and Echinococcus multilocularis are cestode parasites, of which the metacestode (larval) stages cause the diseases cystic echinococcosis (CE) and alveolar echinococcosis (AE), respectively. Albendazole and mebendazole are presently used for chemotherapeutical treatment. However, these benzimidazoles do not appear to be parasiticidal in vivo against AE. In addition, failures in drug treatments as well as the occurrence of side-effects have been reported. New drugs are needed to cure AE and CE, which are considered to be neglected diseases. Strategies currently being implemented to identify novel chemotherapeutical treatment options include (i) conventional primary in vitro testing of broad-spectrum anti-infective drugs, either in parallel with, or followed by, animal experimentation ; (ii) studies of drugs which interfere with the proliferation of cancer cells and of Echinococcus metacestodes ; (iii) exploitation of the similarities between the parasite and mammalian signalling machineries, with a special focus on targeting specific signalling receptors ; (iv) in silico approaches, employing the current Echinococcus genomic database information to search for suitable targets for compounds with known modes of action. In the present article, we review the efforts toward obtaining better anti-parasitic compounds which have been undertaken to improve chemotherapeutical treatment of echinococcosis, and summarize the achievements in the field of host-parasite interactions which may also lead to new immuno-therapeutical options.

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Section: I M I T a T I O N S O F C U R R E N T C H E M O T H E R A mentioning

confidence: 99%

Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis

et al. 2007

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“…Albendazol 15 mg/kg/gün (maksimum 800 mg/gün) iki dozda 28 günlük kürler halinde 4-6 ay süre ile kullanılmaktadır. Medikal tedavi ile kür %60-90 arasında iken, %30 olgu tedaviye cevapsızdır ve %10-20 olguda nüks görülmektedir (15,16). Albendazolün en sık bildirilen yan etkileri karaciğer enzimlerinde artış, ciddi 250 lökopeni, trombositopeni ve alopesidir.…”

Section: Discussionunclassified

Child with Pancreatic Hydatid Cyst Presenting with Cholestasis

Aslan¹,

Koca²,

Aktaş³

et al. 2017

TurkiyeParazitolDerg

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ÖZKistik ekinokokkozis sıklıkla karaciğer ve akciğerde görülmekle birlikte birçok organda yerleşim gösterebilir. Hastalığın endemik olarak gö-rüldüğü ülkelerde bile pankreas yerleşimli hidatik kist olguları nadir olup, genellikle izoledir. Pankreas kist hidatikleri özellikle psödokist ve pankreasın kistik karsinomları ile ayırıcı tanısının yapılması gereken olgular olması nedeni ile önem taşımaktadır. Literatür (PubMed) taramasında çocukluk yaş grubunda pankreas ile birlikte karaciğerin de tutulduğu kistik ekinokokkozis olgusuna rastlayamadık. Bu yazıda, kolestazla gelen çocukta pankreatik kistik ekinokokkozisin etyolojide rol alabileceği ve bu kistin izole olmayabileceği vurgulanıp, olgu literatür ışığında tartışıldı. Anahtar Kelimeler: Kistik ekinokokkozis, kolestaz, pankreas Geliş Tarihi: 30.08.2015Kabul Tarihi: 29.03.2016 ABSTRACTAlthough hydatid cysts are often seen in the liver and lungs, they may be present in many organs. Even in countries where hydatid cyst disease is endemic, the occurrence of pancreatic hydatid cysts is rare. Pancreatic hydatid cysts are important for the differential diagnosis of patients with pancreatic pseudocysts and cystic carcinomas. We could not find cystic echinococcosis cases which are kept together pancreas and liver in PubMed. In this article, we highlight the fact that pancreatic cystic echinococcosis may play a role in the etiology of cholestasis and that cysts may not be isolated in the pancreas in a pediatric population.

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“…Cytogenetic assays have been used since the early 1960s to evaluate the exposure of patients to potentially mutagenic and carcinogenic agents (Chai et al, 2004). SCE, MI and CA analyses were used in many such studies.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

et al. 2007

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57 SummaryCystic echinococcosis (CE) due to Echinococcus granulosus is one of the most important helminthic diseases in Turkey where it constitutes a public health and economic problems. Its mean annual incidence in humans is 4.4/100 000 and the prevalence of the tapeworm agent in domestic animals ranges from 11.2 to 50.7 %. Since 1980s, albendazole has been used for treatment of the disease, and this benzimidazole drug has been considered to be of relatively low toxicity. However, prolonged albendazole therapy of CE became to be a common practice, and data on possible genotoxic effects of the medication in humans are lacking. This study has concerned 17 women and 11 men, in total 28 patients with liver cystic hydatid complaints, who were administered albendazole (15 mg/kg) preoperatively (2 weeks) and postoperatively (6 months). Genotoxic effects of albendazole were searched using Sister Chromatid Exchange (SCE), mitotic index (MI) and chromosomal aberations (CAs) methods, comparing lymphocyte chromosomes of treated patients and a control group of healthy individuals. The results indicated a significant increase of SCE frequencies and decrease of MI in the treated group (p < 0.001). Regarding CAs, any difference between the groups was not determined.

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Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis

Cited by 45 publications

References 10 publications

Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis

Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis

Child with Pancreatic Hydatid Cyst Presenting with Cholestasis

Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

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