Objective Evaluation of the Effect of Q-Switched Nd:YAG (532 nm) Laser on Solar Lentigo by Using a Colorimeter

Kim, Ji Seok; Nam, Chan Hee; Kim, Jee Young; Gye, Ji Won; Hong, Soon-Tae; Kim, Myung Hwa; Park, Byung Cheol

doi:10.5021/ad.2015.27.3.326

Cited by 14 publications

(18 citation statements)

References 4 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean age was 49.35 ± 11.10 and 52.75 ± 10.67 years in TA and placebo group, respectively. Median (range) disease duration was 10 years in TA group and 8.5 years in placebo group. Most of the patients had Fitzpatrick skin type III or IV, numbering 18 (90%) in TA group and 15 (75%) in placebo group.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q‐Switched 532‐nm Nd:YAG Laser for Solar Lentigines

et al. 2019

View full text Add to dashboard Cite

Background and Objectives Q‐switched (QS) 532‐nm Nd:YAG laser is one of the treatment options for solar lentigines (SLs). However, the high incidence of postinflammatory hyperpigmentation (PIH) is concerning, especially in dark‐complexioned skin. Tranexamic acid (TA) can decrease melanogenesis and has been used to treat melasma. The aim of this study is to evaluate the efficacy and safety of oral TA for PIH prevention and clearance in patients with SL treated with QS 532‐nm Nd:YAG laser. Study Design/Materials and Methods Forty patients with SL treated with QS 532‐nm Nd:YAG laser were enrolled in this randomized controlled trial. They were randomly assigned to be receive oral TA 1,500 mg daily or placebo for 6 weeks. Results were evaluated by blinded investigators using digital photographs, dermatoscopy, colorimetry, physician grading scores, and patient satisfaction scores at baseline, 2nd, 4th, 6th, and 12th weeks. Results The incidence of PIH, relative melanin value, lightness index, and clinical improvement scores were not significantly different between the two groups. However, the TA group had a significantly lower incidence of dermatoscopic finding of pigmented granules, which correspond to PIH at 6th and 12th weeks (P = 0.038 and 0.013, respectively). Homogenous light brown pigmentation under dermatoscopy was significantly associated with higher clinical improvement. Conclusions Oral TA therapy starting at the first day postlaser treatment is not effective for PIH prevention after QS 532‐nm Nd:YAG laser in SL. However, PIH clearance, as assessed dermatoscopically, is significantly improved by oral TA at 6th and 12th week. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The QS 532‐nm Nd:YAG laser is a popular treatment for SL. However, the incidence of PIH associated with laser treatment is relatively high, especially in dark‐skinned patients . To prevent PIH, several modalities using before, during, and after the procedure have been reported with variable results .…”

Section: Discussionmentioning

confidence: 99%

A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q‐Switched 532‐nm Nd:YAG Laser for Solar Lentigines

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Post‐care may affect the risk of PIH with regimens varying in prior comparison studies We routinely use topical steroid at least seven days after treatment because it is thought to reduce the risk of PIH after laser treatment by reducing inflammation . In our previous study of QS laser, 0.12% betamethasone valerate plus 0.1% gentamicin sulfate was applied , which is stronger than the 0.05% clobetasone butylate used in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…In that study, 355 solar lentigines in 195 patients were treated by two different QS lasers following use of hydroquinone and evaluated to compare treatment efficacy and incidence of PIH [9]. Kim et al reported 20% PIH among 20 patients and Kang et al reported 20.3% incidence among 516 patients in their studies of removing solar lentigines [10,11]. The current study had a higher rate of PIH than did a previous retrospective study by Guss et al where they reported 0.8% incidence of PIH in the removal of 255 lentigines from six patients with skin type IV from various races, which were treated by a picosecond Nd:YAG laser [20].…”

Section: Discussionmentioning

confidence: 99%

“…laser 1064-nm, the QS Ruby laser 694-nm, and the QS Alexandrite laser 755-nm often provide effective treatment. However, there is a high incidence of adverse effects such as post-inflammatory hyperpigmentation (PIH), which has been reported as 10-47% in previous studies, and is a serious concern in darker skin types [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective study of removing solar lentigines in Asians using a novel dual‐wavelength and dual‐pulse width picosecond laser

2018

View full text Add to dashboard Cite

To the best of our knowledge, this is the first study using a picosecond Nd:YAG laser 532-nm for removing solar lentigines in darker skin types that includes histological evaluation. Although there are many options to treat solar lentigines, our results suggest that picosecond laser with preferable endpoint determination can be a safer and more effective treatment over conventional treatments in Asian patients. Lasers Surg. Med. 50:851-858, 2018. © 2018 Wiley Periodicals, Inc.

show abstract

A longitudinal comparative study by in vivo harmonic generation microscopy: Q‐switched ruby laser versus picosecond 532‐nm Nd: YAG laser for the treatment of solar lentigines

Chen

Sheen

et al. 2022

JEADV Clinical Practice

View full text Add to dashboard Cite

Background: Nanosecond quality-switched ruby laser (QSRL) and frequencydoubled 532-nm picosecond Nd:YAG laser (532-nm picosecond Nd: YAG laser [PSNYL]) are well-documented treatments for solar lentigines (SLs). However, no studies have longitudinally tracked the microscopic findings before and after QSRL and 532-nm PSNYL treatment for SL removal.Objectives: To compare the clinical efficacy and dynamic histological changes between QSRL and 532-nm PSNYL in the treatment of SLs in Asian patients.Method: Twenty-five patients with SLs on both sides of the face were enrolled in this prospective split-face study. QSRL and 532-nm PSNYL therapy for SLs on the left and right side of the face, respectively, were performed for each subject. All subjects underwent baseline and follow-up assessment at Weeks 3 and 6. In vivo harmonic generation microscopy (HGM) imaging was adopted for the noninvasive observation of melanin mass density of basal cells (MMD basal cell ), epidermal melanocyte dendricity, and dermal melanophages before and after laser treatment.Results: At Week 6, 60% of the lesions treated with QSRL and 68% with 532-nm PSNYL had over 75% improvement. Histologically, both lasers resulted in statistically significant decrease of MMD basal cell in SLs to the level of that in the normal skin at Weeks 3 and 6. Statistically significant increase of dermal melanophages was observed 3 weeks after both laser treatments.Nevertheless, 532-nm PSNYL led to faster clearance of melanophages than QSRL at Week 6. Moreover, activated melanocytes with enhanced dendrite formation was significantly increased till 6 weeks after both laser treatments. Conclusion:Both QSRL and 532-nm PSNYL were effective treatments for SLs, and there was no statistically significant difference in clinical scoring. However,

show abstract

Objective Evaluation of the Effect of Q-Switched Nd:YAG (532 nm) Laser on Solar Lentigo by Using a Colorimeter

Cited by 14 publications

References 4 publications

A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q‐Switched 532‐nm Nd:YAG Laser for Solar Lentigines

A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q‐Switched 532‐nm Nd:YAG Laser for Solar Lentigines

Prospective study of removing solar lentigines in Asians using a novel dual‐wavelength and dual‐pulse width picosecond laser

A longitudinal comparative study by in vivo harmonic generation microscopy: Q‐switched ruby laser versus picosecond 532‐nm Nd: YAG laser for the treatment of solar lentigines

Contact Info

Product

Resources

About