Prospective study of removing solar lentigines in Asians using a novel dual‐wavelength and dual‐pulse width picosecond laser

Negishi, Kei; Akita, Hirotaka; Matsunaga, Yukiko

doi:10.1002/lsm.22820

Cited by 58 publications

(104 citation statements)

References 28 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of PIH in lesions was 10.2% which was slightly higher compared with other published literature [18,19]. Although Guss et al [20] reported an incidence of 0.8% of PIH in the removal of 255 lentigines from six patients, and Negishi et al [3] reported an incidence of 4.65% in the treatment of 43 lesions in 20 females, we believe our results still support that the picosecond laser is a safe treatment option for the treatment of solar lentigines. Our laser setting was similar to that of Negishi et al which used parameters of 532-nm, low energy green mode, 750 ps, average fluence 0.35 ± 0.6 J/cm 2 (range 0.2-0.5) spot size 3 or 4 mm with a repetition rate of single or 1 Hz, where our parameters were 532-nm, 750 ps, fluence of 0.2-0.5 J/cm 2 , with a repetition rate of 2 Hz.…”

Section: Discussionsupporting

confidence: 49%

“…The shorter pulse widths in the picosecond domain destroys melanosomes not only through photothermal effect but also through photo‐acoustic effect. Negishi et al further demonstrated this through histological findings of destroyed melanosomes with surrounding structural damage with QS Nd:YAG laser, whereas no obvious surrounding structural damage was observed in picosecond laser treated skin samples . At even shorter pulse duration than picosecond, plasma formation can be a complication.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

A Prospective Study in the Treatment of Lentigines in Asian Skin Using 532 nm Picosecond Nd:YAG Laser

et al. 2019

View full text Add to dashboard Cite

Background and Objective To evaluate safety and efficacy of treatment with the picosecond Nd:YAG 532 nm for lentigines in Asian skin. Study Design/Materials and Methods This was a prospective, open‐label cohort study, using a novel picosecond 532‐nm laser for the treatment of facial lentigines. Subjects received up to three laser treatments every 4–6 weeks and were assessed at 4 and 12 weeks after final treatment. Primary endpoint was degree of improvement in lentigines at 12 weeks after the final treatment, assessed by treating investigator based on Physicians Global Assessment. Secondary end‐points included degree of improvement in lentigines at 12 weeks after final treatment, assessed by subject (Subject's Global Assessment), and change in mean relative Melanin index (MI) value at 3 months after final treatment as compared to baseline as assessed by mexameter measurement. Results A total of 20 patients (3 male, and 17 female) of Asian‐descent with Fitzpatrick skin type III and IV, with lentigines on the face were included in this study. A total of 89 lesions were treated with the laser setting of 532‐nm, 750 picoseconds, fluence of 0.2–0.5 J/cm 2, and spot size of 4 mm. One hundred and thirty‐seven treatment sessions were given in total. Eighteen patients (90%) achieved a moderate to significant improvement at 12‐week follow‐up based on a 5‐grade physician global assessment scale. The improvement rate of relative MI (MI in the lesion minus normal skin) was 33.30 ± 18.71 and 37.63 ± 19.25% at 4‐ and 12‐week follow‐up. Post‐inflammatory hyperpigmentation (PIH) occurred in 14 of 137 sessions (10.2%), and hypopigmentation occurred in one patient with five lesions (3.6%). Conclusion This study demonstrates that using picosecond Nd:YAG laser 532 nm for removal of solar lentigines in darker skin type appears to be safe and effective. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc. Limitations Small study group.

show abstract

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 98%

A Prospective Study in the Treatment of Lentigines in Asian Skin Using 532 nm Picosecond Nd:YAG Laser

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It more efficiently breaks down melanin while causing less irritation and fewer complications. It has been reported that PS laser is highly efficient against solar lentigines, yielding a treatment response rate of 93.02% with >75% clearance with only a single treatment, whereas the PIH rate was reported to be lower at 4.65% with a demonstration of minimal disruption of the epidermo-dermal junction when compared with traditional QS lasers [6]. Newer laser wavelengths with PS technology, such as 670 nm, allows deeper penetration and even fewer complications to the normal epidermal melanin while causing less irritation to hemoglobin and blood vessels owing to its high melanin-to-hemoglobin ratio ( Fig.…”

Section: Freckles and Solar Lentiginesmentioning

confidence: 99%

“…It can break down the pigment particles into smaller pieces than can traditional quality-switched (QS) lasers, thereby allowing the immune system to more efficiently remove the fractured pigments. Further, it has been histologically proven that QS lasers more easily www.jcosmetmed.org damage the surrounding tissue than PS lasers [6]. Therefore, PS lasers have better treatment margin and efficacy than QS lasers, and are a good therapeutic option for Asian BPDs.…”

Section: Introductionmentioning

confidence: 99%

Picosecond laser treatment for Asian skin pigments: a review

Wong¹

2019

J Cosmet Med

View full text Add to dashboard Cite

Picosecond (PS) laser is a novel dermatological laser technology that is useful in treating various cutaneous benign pigmentary disorders (BPDs), including freckles, solar lentigines, melasma, Hori macule, nevus of Ota, post-inflammatory hyperpigmentation, and tattoo. Treating Asian BPDs can be troublesome as Asian skin is typically associated with a high incidence of laser complications, such as burns, hyperpigmentation/hypopigmentation, and textural changes, which can result in various cosmetic and even psychosocial problems. This study aimed to describe the PS laser treatment for common Asian BPDs compared with traditional laser treatments. Peer-reviewed articles published from 1965 to 2018 were identified from PubMed and Google Scholar, and qualitatively reviewed with respect to the treatment of Asian BPDs. PS lasers achieved greater effectiveness and potentially fewer complications in the treatment of Asian BPDs through breakthrough mechanisms including photomechanical effects and laser-induced optical breakdown. PS laser is especially suitable and effective for treating various BPDs in Asian skin.

show abstract

“…This treatment strategy however is quite challenging because of the high risk of damage to surrounding tissues that can lead to long-lasting and delayed postinflammatory hyperpigmentation. So, proper patient counseling with regard to side effects, and expectations should always be done prior to any laser therapy [45,46].…”

Section: Laser Therapymentioning

confidence: 99%

On the Intricacies of Facial Hyperpigmentation and the Use of Herbal Ingredients as a Boon for Its Treatment: Cosmeceutical Significance, Current Challenges and Future Perspectives

Parveen¹,

Ali²,

Ali³

2019

Depigmentation

View full text Add to dashboard Cite

Facial hyperpigmentation is the term used to express areas on irregular pigmentation in the skin. It appears as darkened patches on the face that make the facial skin look uneven. Facial hyperpigmentation is not physically debilitating but has been associated with enhanced psychosocial complications including anger, depression and frustration. These psychosocial burdens, in turn, have inference on quality of life and self-esteem. So, the treatment of facial hyperpigmentation seems to be a growing concern to the dermatologists today and they have been practising several treatment modalities including chemical peeling, laser therapy, dermabrasion, etc. But, those are found to be associated with various after-effects. Hence, the use of plants and its products is highly recommended as they are reported with either none or fewer after-effects. The present chapter draws attention to the forms of facial hyperpigmentation with their aetiologies and available treatment options for them with associated side effects. Furthermore, we have discussed about the other side of treatment with herbal ingredients which are safe and have less or no side effects. This chapter will be of value to the dermatologists who are searching for naturally derived ingredients for treating facial hyperpigmentation, in line with consumer expectations and preferences.

show abstract

Prospective study of removing solar lentigines in Asians using a novel dual‐wavelength and dual‐pulse width picosecond laser

Cited by 58 publications

References 28 publications

A Prospective Study in the Treatment of Lentigines in Asian Skin Using 532 nm Picosecond Nd:YAG Laser

A Prospective Study in the Treatment of Lentigines in Asian Skin Using 532 nm Picosecond Nd:YAG Laser

Picosecond laser treatment for Asian skin pigments: a review

On the Intricacies of Facial Hyperpigmentation and the Use of Herbal Ingredients as a Boon for Its Treatment: Cosmeceutical Significance, Current Challenges and Future Perspectives

Contact Info

Product

Resources

About