Objective assessment of photoageing effects using high-frequency ultrasound in PUVA-treated psoriasis patients

Abstract

Long-term PUVA treatment in psoriasis patients accelerates thinning of the skin in comparison to age-matched controls. The results show that ultrasonography is a sensitive method to investigate the effects of PUVA-induced skin ageing.

Medium-dose is more effective than low-dose ultraviolet A1 phototherapy for localized scleroderma as shown by 20-MHz ultrasound assessment

“…Three patients had skin type II; the others had skin type III. On average, the patients had 9 plaques (range [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

“…18 The probe had a frequency of 20 MHz. Because of limited axial resolution, normal epidermis could not always be viewed separately, which is why the total thickness of epidermis and dermis was measured.…”

Phototherapy and Photochemotherapy for Psoriasis

“…32 An increased risk of cataract can be expected in patients undergoing PUVA or NB-UV-B therapy based on animal studies. 33 Therefore, eye protection is essential during irradiation, and additional UV-blocking glasses are recommended during daytime in patients who take oral psoralens.…”

A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women

“…These data are comparable to ours, given that we measured a median increase in skin thickness of 6.4% after 7 months of HRT. No major changes may be expected over a period of 7 months in patients with a skin thickness of around 1 mm, for, as we found in an earlier study 13 , the skin of patients after 20 years of psoralen plus ultraviolet A (PUVA) therapy was only 1.1-14.4% thinner than that of comparable persons without PUVA treatment, depending on the measuring site. An improvement of that magnitude within a 7-month period may thus Hormone replacement therapy and skin aging Sator et al…”

“…The results are imaged in both A-scan and B-scan modes. The method is described in a previous report 13 . As normal epidermis cannot always be viewed separately due to limited axial resolution, the total thickness of the epidermis and dermis was measured.…”