A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women

Sator, Paul; Sator, Michael; Schmidt, J B; Nahavandi, Hesam; Radaković, Sonja; Huber, Johannes; Hönigsmann, Herbert

doi:10.1080/13697130701444073

Cited by 71 publications

(37 citation statements)

References 31 publications

(31 reference statements)

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“…Both chronologically aged and photoaged skin exhibit defective epidermal permeability barrier function and reduced skin elasticity [6,[30][31][32][33] . And sex hormones also regulate epidermal barrier function and stratum corneum hydration [34,35] . The present study demonstrates that skin friction coefficient is also associated with age and gender, which is inconsistent with previous reports [21,22,[25][26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

Characterization of Skin Friction Coefficient, and Relationship to Stratum Corneum Hydration in a Normal Chinese Population

Zhu

Shu-min

Luo

et al. 2010

Skin Pharmacol Physiol

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Background and Objectives: Studies have demonstrated that some cutaneous biophysical properties vary with age, gender and body sites. However, the characteristics of the skin friction coefficient in different genders and age groups have not yet been well established. In the present study, we assess the skin friction coefficient in a larger Chinese population. Methods: A total of 633 subjects (300 males and 333 females) aged 0.15–79 years were enrolled. A Frictiometer® FR 770 and Corneometer® CM 825 (C&K MPA 5) were used to measure the skin friction coefficient and stratum corneum hydration, respectively, on the dorsal surface of the hand, the forehead and the canthus. Results: In the females, the maximum skin friction coefficients on both the canthus and the dorsal hand skin were observed around the age of 40 years. In the males, the skin friction coefficient on the dorsal hand skin gradually increased from 0 to 40 years of age, and changed little afterward. Skin friction coefficients on some body sites were higher in females than in age-matched males in some age groups. On the canthus and the dorsal hand skin of females, a positive correlation was found between skin friction coefficient and stratum corneum hydration (p < 0.001 and p < 0.0001, respectively). In contrast, in males, the skin friction coefficient was positively correlated with stratum corneum hydration on the forehead and the dorsal hand skin (p < 0.05 and p < 0.0001, respectively). Conclusion: The skin friction coefficient varies with age, gender and body site, and positively correlates with stratum corneum hydration on some body sites.

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Section: Discussionmentioning

confidence: 99%

Characterization of Skin Friction Coefficient, and Relationship to Stratum Corneum Hydration in a Normal Chinese Population

Zhu

Shu-min

Luo

et al. 2010

Skin Pharmacol Physiol

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“…Hormone replacement therapy has been correlated with enhancement of collagen production, increase in skin thickness, surface lipids, hydration, vascularisation and increase of the hair follicle life cycle (Brincat, 2000;Callens et al, 1996;Fuchs et al, 2003;Patriarca et al, 2007;Sator et al, 2007;Sator et al, 2001) leading to an improvement of skin tone and appearance. Hormone replacement may only improve the skin quality in female patients treated during the first 24 months after menopause (Phillips et al, 2008) (Table I).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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“…Additionally, both skin temperature and sebum content decrease significantly on the forehead of menopausal women, and SC hydration declines in postmenopausal women [17] . On the other hand, systemic administration of estrogen improves SC hydration, and topical estrogens improve skin elasticity and skin firmness, suggesting that hormones regulate the physical properties of the skin [18][19][20] . Development of many pharmaceutical and skin care products has relied upon what is known about these parameters.…”

mentioning

confidence: 99%

Variation of Skin Surface pH, Sebum Content and Stratum Corneum Hydration with Age and Gender in a Large Chinese Population

Man

Xin

Shu-min

et al. 2009

Skin Pharmacol Physiol

217

225

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Background and Objectives: Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which was in part due to small sample size. Additionally, little is known about the skin physical properties of Asian, especially Chinese, subjects. In the present study, we assess the difference in skin surface pH, sebum content and SC hydration at various ages and in both genders in a large Chinese population without skin diseases. Methods: 713 subjects (328 males and 385 females) aged 0.5–94 years were enrolled in this study. The subjects were divided by age into 5 groups, i.e., 0–12, 13–35, 36–50, 51–70 and over 70 years old. A multifunctional skin physiology monitor was used to measure SC hydration, skin surface pH and sebum content on both the forehead and the forearms. Results: In males, the highest sebum content was found on the forearm and the forehead in the age groups 36–50 (93.47 ± 10.01 μg/cm²) and 51–70 years (9.16 ± 1.95 μg/cm²), while in females, the highest sebum content was found on the forearm and the forehead in the age groups 13–35 (61.91 ± 6.12 μg/cm²) and 51–70 years (7.54 ± 2.55 μg/cm²). The forehead sebum content was higher in males aged 13–70 years than in age-matched females; the sebum content on the forehead in both males and females was higher than that on the forearm. Skin surface pH on the forehead of both males and females over the age of 70 years was higher than that in younger groups. SC hydration on the forehead in both males and females was lower above the age of 70, and the one in males aged 13–35 was higher than that in females (43.99 ± 1.88 vs. 36.38 ± 1.67 AU, p < 0.01). SC hydration on the forehead in both males and females did not significantly differ from that on the forearm. Conclusions: In a large Chinese cohort, the skin surface pH, sebum content and SC hydration vary with age, gender and body site.

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A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women

Abstract: The results showed improvements in the parameters involved in skin aging in the HRT group as compared to baseline. While skin aging is no indication for systemic hormone supplementation, a positive effect on aging skin can be observed.

Cited by 71 publications

References 31 publications

Characterization of Skin Friction Coefficient, and Relationship to Stratum Corneum Hydration in a Normal Chinese Population

Characterization of Skin Friction Coefficient, and Relationship to Stratum Corneum Hydration in a Normal Chinese Population

Skin and brain age together: The role of hormones in the ageing process

Variation of Skin Surface pH, Sebum Content and Stratum Corneum Hydration with Age and Gender in a Large Chinese Population

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