Medium-dose is more effective than low-dose ultraviolet A1 phototherapy for localized scleroderma as shown by 20-MHz ultrasound assessment

Phototherapy for sclerosing skin conditions

“…This study concluded that medium-dose UVA1 therapy was superior to NB UVB therapy. Similar to Sator et al, a significant decrease in skin thickness via ultrasound measurements was seen only with the administration of medium-dose UVA1 (50 J/ cm 2 ) [29]. Additional studies continue to support the efficacy of medium-dose UVA1 therapy both in the long-term and shortterm treatment of morphea [31], and the evidence suggests that satisfactory results can be achieved with medium-dose UVA1 therapy delivered over 25-35 sessions.…”

“…Outcome measures included change in clinical examination, skin score, ultrasound measurements, cutometer measurements, skin biopsy specimens or a composite of these measures [21,23,25,[27][28][29]. More recently, Sator et al conducted a randomized controlled study to evaluate the immediate-and long-term efficacy of low-dose versus medium-dose UVA1 phototherapy [29]. In this study, 16 patients with at least three lesions of plaque-type morphea (comparable in location and evolution) were included and treated with either 20 or 70 J/cm 2 UVA1 or no radiation for a total of 30 sessions.…”

Concomitant en coup de sabre and plaque type morphea in the same patient: a rare occurrence

“…Badanie głowy metodą rezonansu magnetycznego może wykazać nieprawidłowości, takie jak poszerzenie komory mózgu, zanik kory mó-zgowej i zwapnienie jąder podkorowych [6]. Ultrasonografia z wykorzystaniem częstotliwości 10-25 MHz pomaga w określeniu grubości skóry i ocenie aktywności choroby [7]. Badanie elektroencefalograficzne umoż-liwia ocenę czynności mózgu i uwidocznienie nieprawidłowości, nawet w razie braku napadów.…”

“…Magnetic resonance imaging of the brain and skull may reveal abnormalities such as dilated ventricle, atrophy of the cortex and subcortical calcification [6]. A 10-25 MHz ultrasound scan can help to measure the skin thickness and assess disease activity [7]. An electroencephalogram may be employed to study brain activity and may reveal abnormalities even in the absence of seizures.…”

Current Approach to Phototherapy Applications in Dermatology Practice: Part 2. Phototherapy in Vitiligo, Mycosis Fungoides, Atopic Dermatitis, Sclerosing Diseases and Psoriasis

“…Ancak, orta doz UVA1 dar bant UVB'den daha etkili bulunurken, düşük doz UVA1 ile dar bant UVB veya orta doz UVA1 arasında fark saptanmamıştır (73). Orta doz UVA1 ile düşük doz UVA1'in karşılaştırıldığı bir çalışmada ise, 30 seans uygulama sonunda, her iki doz rejiminde de klinik düzelme olduğu ancak istatistiksel olarak anlamlı bir farklılık görülemediği, buna karşılık, ultrasonografik ölçümle değerlendirilen deri kalınlığındaki azalmanın orta doz rejiminde anlamlı olarak daha fazla olduğu belirtilmiştir (74). MF ve AD'de olduğu gibi, lokalize sklerodermada da UVA1 ile başarılı tedavi sonrası nüks olabilmektedir.…”