Objective Analysis of Hyperreflective Outer Retinal Bands Imaged by Optical Coherence Tomography in Patients With Stargardt Disease

Park, Jason C; Collison, Frederick T; Fishman, Gerald A.; Allikmets, Rando; Zernant, Jana; Liu, Meilin; McAnany, J. Jason

doi:10.1167/iovs.15-16955

Cited by 21 publications

(21 citation statements)

References 25 publications

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“…the cone outer‐segment terminals [‘IZ band’]) are often not visible throughout the entire central macula in all subjects (Park et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…However, this can be a difficult task, as the subtle retinal structures that are necessary for appropriate segmentation (e.g. the cone outer-segment terminals ['IZ band']) are often not visible throughout the entire central macula in all subjects (Park et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…; Park et al. ) that was performed in MATLAB using custom‐written software. Two anatomical markers were defined, as shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Figure 1 shows an example OCT image and the region of the image that was analysed (white vertical dashed lines), which had a diameter equivalent to 6°(centred on the fovea). The images were segmented using a standard semi-automated approach (Hood et al 2011;Park et al 2015) that was performed in MATLAB using custom-written software. Two anatomical markers were defined, as shown in Fig.…”

Section: Apparatus Stimuli Procedure and Analysismentioning

confidence: 99%

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Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy

McAnany

Park

Liu

et al. 2019

Acta Ophthalmologica

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Purpose To determine the relationship between contrast sensitivity (CS) and outer‐retina thickness (ORT) in diabetics who have minimal or no diabetic retinopathy (DR). Methods Twenty non‐diabetic control subjects and 40 type‐2 diabetic subjects participated (20 had no clinically apparent DR [NDR] and 20 had mild non‐proliferative DR [NPDR]). No subject had a history of treatment for macular oedema. Letter CS, microperimetry (MP) sensitivity and visual acuity (VA) were measured. Letter CS and MP measurements were performed over the central 6° of the visual field. Spectral domain optical coherence tomography (SD‐OCT) images were obtained at corresponding locations, outer‐retina thickness was quantified, and structure–function relationships were evaluated. Results Analysis of variance indicated significant letter CS differences among the groups (p < 0.001). Letter CS was reduced significantly for the mild NPDR group (p < 0.001; 33% reduction), but not the NDR group (p = 0.08). There were no significant differences in MP sensitivity or ORT among the groups (both p > 0.10). Nevertheless, Hoeffding's D tests indicated significant associations between ORT and letter CS (p < 0.001) and between ORT and MP sensitivity for the mild NPDR group (p = 0.01). VA was not significantly associated with ORT for either diabetic group (both p > 0.49). Conclusions Outer‐retina thickness is associated with letter CS and MP sensitivity, but not VA, in mild NPDR. This finding highlights the usefulness of simple letter CS measures and suggests neural dysfunction can occur in the absence of marked structural abnormalities in early‐stage DR.

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“…the cone outer‐segment terminals [‘IZ band’]) are often not visible throughout the entire central macula in all subjects (Park et al. ).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…; Park et al. ) that was performed in MATLAB using custom‐written software. Two anatomical markers were defined, as shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Section: Apparatus Stimuli Procedure and Analysismentioning

confidence: 99%

See 2 more Smart Citations

Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy

McAnany

Park

Liu

et al. 2019

Acta Ophthalmologica

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“…The external edge of the ring was preferred over the internal edge owing to its greater definition and distinct appearance, allowing for more precise measurements. The interest in studying photoreceptor survival led to the decision to measure the EZ line width due its reliability, as opposed to the interdigitation zone (IZ) line, which cannot always be distinguished, even in normal subjects [30]; the EZ line is readily detectable in every patient. The EZ width was manually measured on the high-resolution horizontal scan through the fovea using the measuring tool in the Spectralis software (Figure 7).…”

Section: Image Acquisition and Measurementsmentioning

confidence: 99%

Comparative Analysis of Functional and Structural Decline in Retinitis Pigmentosas

Cabral

Carvalho

Kim

et al. 2020

IJMS

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Retinitis pigmentosa (RP) is a category of inherited retinal dystrophies that is best prognosticated using electroretinography (ERG). In this retrospective cohort study of 25 patients with RP, we evaluated the correlation between 30 Hz flicker ERG and structural parameters in the retina. Internationally standardized 30 Hz flicker ERG recordings, short-wavelength autofluorescence (SW-AF), and spectral domain-optical coherence tomography (SD-OCT) were acquired at two visits at least one year apart. Vertical and horizontal hyperautofluorescent ring diameter measurements with SW-AF, as well as ellipsoid zone (EZ) line width measurements with SD-OCT, were used as structural parameters of disease progression. The 30 Hz flicker ERG amplitude decreased by 2.2 ± 0.8 µV/year (p = 0.011), while implicit times remained unchanged. For SD-OCT, the EZ line decreased by 204.1 ± 34.7 µm/year (p < 0.001). Horizontal and vertical hyperautofluorescent ring diameters decreased by 161.9 ± 25.6 µm/year and 146.9 ± 34.6 µm/year, respectively (p = 0.001), with SW-AF. A correlation was found between the progression rates of the 30 Hz flicker amplitude recorded with Burian-Allen electrodes and both the horizontal ring diameter (p = 0.020) and EZ line (p = 0.044). SW-AF and SD-OCT, two readily available imaging techniques, may be used to prognosticate disease progression because of the reliability of their measurements and correlation with functional outcome.

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Reproducibility of en-face Optical Coherence Tomography Imaging for Macular Atrophy Area Evaluation in Juvenile Macular Degeneration

Melillo

Rossi

Iorio

et al. 2016

XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016

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Objective Analysis of Hyperreflective Outer Retinal Bands Imaged by Optical Coherence Tomography in Patients With Stargardt Disease

Cited by 21 publications

References 25 publications

Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy

Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy

Comparative Analysis of Functional and Structural Decline in Retinitis Pigmentosas

Reproducibility of en-face Optical Coherence Tomography Imaging for Macular Atrophy Area Evaluation in Juvenile Macular Degeneration

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