Reproducibility of en-face Optical Coherence Tomography Imaging for Macular Atrophy Area Evaluation in Juvenile Macular Degeneration

Melillo, Paolo; Rossi, Silvia; Iorio, Valentina Di; Orrico, Ada; D'Alterio, Francesco Maria; Testa, Francesco; Simonelli, Francesca

doi:10.1007/978-3-319-32703-7_50

Cited by 2 publications

(2 citation statements)

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“…The reproducibility of the automated measurements also was assessed in our STGD1 cohort by computing the intraclass correlation coefficient (ICC) between SD-OCT scans performed within 1 week in 15 patients and was excellent (ICC = 0.994; 95% CI, 0.982–0.998). 26 Finally, since FAF was commonly adopted in STGD1 to assess macular atrophy area, 9 , 21 , 27 we compared the RPE lesion area measurements by SD-OCT to the FAF lesion area in the subset of STGD1 patients who underwent both examinations during the same visit. Since most patients underwent only SD-OCT and not FAF examination, only a relatively small number of cases ( n = 22) could be included in the comparison between the two techniques.…”

Section: Discussionmentioning

confidence: 99%

En Face Spectral-Domain Optical Coherence Tomography for the Monitoring of Lesion Area Progression in Stargardt Disease

Melillo

Testa

Rossi

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeWe investigated the progression of Stargardt disease (STGD1) over a multiyear follow-up by evaluating the macular lesion area as computed by an automatic algorithm from spectral-domain optical coherence tomography (SD-OCT).MethodsWe reviewed medical records of STGD1 patients, with a clinical and molecular diagnosis of STGD1 at a single institution, who underwent best-corrected visual acuity (BCVA), fundus photography, SD-OCT, full-field electroretinography, and, when available, fundus autofluorescence (FAF). Regression models were fitted on the selected clinical parameters; in particular, on the macular lesion area computed by SD-OCT, to evaluate the disease progression over a multiyear follow-up.ResultsThe comparison between SD-OCT and FAF, available for 22 patients, showed that macular lesion area, assessed by SD-OCT, significantly correlated with the area of absent FAF (P < 0.001). Moreover, the longitudinal analysis, performed in 98 patients, showed a significant enlargement of macular lesion area at an estimated exponential rate of 4.6% per year (P = 0.046), together with a significant worsening of BCVA (0.06 logMAR per year; P < 0.001) and a significant decrease of macular thickness (1.6% per year; P = 0.005) over the follow-up.ConclusionsThe current study describes, for the first time in literature, a longitudinal analysis of the macular lesion area assessed by SD-OCT in STGD1 disease, showing a significant progression over the follow-up. Our findings suggest that the evaluation of macular lesion area by en face SD-OCT, together with FAF, could drive the choice of the most amenable candidates and the most suitable area to be treated in gene therapy clinical trials.

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Section: Discussionmentioning

confidence: 99%

En Face Spectral-Domain Optical Coherence Tomography for the Monitoring of Lesion Area Progression in Stargardt Disease

Melillo

Testa

Rossi

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…28 Further details about the automated algorithm and its application in STGD can be found elsewhere. [28][29][30][31] MP was performed by an automatic fundus-related perimeter (MP1 Microperimeter; Nidek Technologies, Padova, Italy). The following parameters were used: a fixation target of 28 in diameter consisting of a red cross and a white, monochromatic background with a luminance of 1.27 cd/m 2 .…”

Section: Ophthalmologic Examinationmentioning

confidence: 99%