Comparative Analysis of Functional and Structural Decline in Retinitis Pigmentosas

Cabral, Thiago; Carvalho, José Ronaldo Lima de; Kim, Joonpyo; Oh, Jin Kyun; Levi, Sarah R.; Park, Karen Sophia; Duong, Jimmy; Park, Jun Hyung; Boudreault, Katherine; Belfort, Rubens; Tsang, Stephen H.

doi:10.3390/ijms21082730

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…Additionally, we hypothesized that the implicit time measurement could be inaccurate because of the low ERG waveform amplitude before SO removal. This hypothesis should be verified through correlational studies [44,45].…”

Section: Discussionmentioning

confidence: 92%

Electroretinogram changes before and after silicone oil removal in eyes with macula-off rhegmatogenous retinal detachment

Christou¹,

Zafeiropoulos²,

Bagli³

et al. 2022

Med Hypothesis Discov Innov Optom

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Background: Pars plana vitrectomy (PPV) with silicone oil (SO) injection for rhegmatogenous retinal detachment (RRD) repair may adversely affect electroretinographic responses. This study was aimed at assessing retinal function using electrodiagnostic testing after successful PPV with SO tamponade in the eyes with macula-off RRD. Methods: In this interventional comparative study, eligible participants were recruited prospectively over 1 year. We included the eyes that underwent a single successful three-port PPV with SO tamponade for the primary repair of macula-off RRD. Full-field electroretinogram (ffERG) and multifocal electroretinogram (mfERG) were recorded 1 day before and 3 days after SO removal. The amplitude and implicit time of the a- and b-waves for ffERG and P1 and N1 waves for mfERG were evaluated. The unaffected fellow eyes of the patients were selected as controls. Results: We included the ten eyes of ten patients (seven men and three women) with a mean (standard deviation) age of 58.8 (6.2) years. The mean (SD) interval between the diagnoses of macula-off RRD and PPV was 11.7 (3.6) days. The mean (SD) duration of SO tamponade was 147.8 (34.9) days. Using ffERG, significantly lower a- and b-wave amplitudes were found in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P < 0.05). Using the mfERG, treated eyes had significantly lower P1 amplitudes in the central R1+R2+R3 rings and in the R4 and-R5 peripheral rings of the macular area in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P < 0.05). The wave implicit time in ffERG and mfERG did not differ significantly in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P > 0.05). Conclusions: The electrical retinal response density in ERG waveforms increased following SO removal, indicating amelioration of the electrical activity of the retina and macula. These results indicate that the adverse effects of SO tamponade on electroretinography responses may be reversible with removal. In addition, ffERG and mfERG can be used to monitor retinal function in the eyes with macula-off RRD and SO tamponade. Further clinical trials are required to verify the preliminary findings of this study.

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Section: Discussionmentioning

confidence: 92%

Electroretinogram changes before and after silicone oil removal in eyes with macula-off rhegmatogenous retinal detachment

Christou¹,

Zafeiropoulos²,

Bagli³

et al. 2022

Med Hypothesis Discov Innov Optom

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“…Introducing more diversity of animal models for vision biology is crucial to expanding our understanding of the range of visual capabilities and adaptations across the animal kingdom. Furthermore, retinal degenerative eye diseases such as macular degeneration and retinitis pigmentosa affect millions of people worldwide 55,56 . Studying the retinas of animals with good daytime vision (such as Meriones ) or enhanced regenerative abilities (such as Acomys ) could facilitate discoveries that open new therapeutic avenues to treat these sight threatening conditions.…”

Section: Discussionmentioning

confidence: 99%

Retinal neuroanatomy of two emerging model organisms, the spiny mouse (Acomys dimidiatus) and the Mongolian gerbil (Meriones unguiculatus)

Bills,

Seifert,

Morris

2024

Preprint

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Purpose: Degenerative eye diseases such as macular degeneration and retinitis pigmentosa slowly deteriorate vision, ultimately leading to blindness. Current research with laboratory animal models largely utilizes small mammals that are nocturnal and lack the ability to restore lost vision. In contrast, the Mongolian gerbil is a diurnal rodent with good photopic vision, and the eastern spiny mouse is a small desert-dwelling rodent with remarkable regenerative capabilities. The goal of this study was to identify several antibodies that detect retinal cell classes inMerionesandAcomys, and to describe the retinal anatomy of these two species in comparison to outbred laboratory mice (Mus musculus). Methods: Retinal sections were obtained from adult eyes and subjected to histological or immuno-staining with antibodies for various retinal cell types. Sections were imaged by light, fluorescence, and confocal microscopy, assessing cell number and morphology. Cell density, morphology, and placement were compared between species qualitatively and quantitatively. Results: Immunohistochemical visualization and analysis of all general classes of retinal neurons and Müller glia revealed a classic assembly of retinal cells with a few deviations compared toMus.Merionesdisplayed the highest density of cone photoreceptors andAcomysthe lowest. A higher density of bipolar cell bodies in the proximal portion of the inner nuclear layer was observed in bothAcomysandMerionescompared toMus, and both species exhibited an increase in amacrine cell density compared toMus. Conclusion: We have characterized similarities and differences in the retinal anatomy and cellular density betweenMeriones,Acomys, andMus. We identified several commercially available antibodies that reliably detect retinal cell types in theAcomysandMerionesretina. Our results provide a foundation for future research into the visual system adaptations of both of these interesting rodent species.

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The Use of Optical Coherence Tomography in Evaluation of Retinitis Pigmentosa

Kim

Tsang

2022

Methods in Molecular Biology

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Comparative Analysis of Functional and Structural Decline in Retinitis Pigmentosas

Cited by 7 publications

References 29 publications

Electroretinogram changes before and after silicone oil removal in eyes with macula-off rhegmatogenous retinal detachment

Electroretinogram changes before and after silicone oil removal in eyes with macula-off rhegmatogenous retinal detachment

Retinal neuroanatomy of two emerging model organisms, the spiny mouse (Acomys dimidiatus) and the Mongolian gerbil (Meriones unguiculatus)

The Use of Optical Coherence Tomography in Evaluation of Retinitis Pigmentosa

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