Obesity: The preventive role of the pomegranate (Punica granatum)

Al-Muammar, May N.; Khan, Fozia Hanif

doi:10.1016/j.nut.2011.11.013

Cited by 146 publications

(112 citation statements)

References 114 publications

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“…As we used the same extract as in Neyrinck et al [34], the different results found in the literature can likely be explained by the composition of the extracts. Indeed, Vroegrijk et al [33] used a pomegranate seed oil rich in punicic acid, whereas the two main polyphenols of our pomegranate peel extract were punicalagin and ellagic acid [12].…”

Section: Discussionmentioning

confidence: 84%

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Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice

et al. 2014

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Purpose We tested the hypothesis that polyphenol-rich extracts can reduce endoplasmic reticulum (ER) stress induced by a high-fat diet (HFD) in skeletal muscle of mice. Methods Mice were randomly assigned to four groups receiving during 20 weeks either a standard chow control (CTRL), or a HFD supplemented, or not, with pomegranate (HFD ? P) or green tea (HFD ? GT) extracts. After the nutritional intervention, mice were killed and gastrocnemius muscles were taken. Proteins and mRNA were measured by Western blot and RT-qPCR, respectively. Results Body weight gain and visceral fat were higher in HFD, HFD ? P and HFD ? GT than in CTRL. The markers of the unfolded protein response BiP, XBP1u, XBP1s and ATF4 were higher only in HFD. In HFD ? P and HFD ? GT, this increase was not observed except for CHOP, which was elevated in all HFD groups. HFD increased also markers of ubiquitin-proteasome pathway, autophagy and oxidative stress, which were kept low in HFD ? P and HFD ? GT groups. Conclusion Our data provide evidence for a protective effect of pomegranate and green tea extracts against ER stress, oxidative stress and protein degradation induced by HFD in skeletal muscle. They give arguments for a usefulness of these natural nutritional compounds to fight against cellular dysfunctions related to fat excess.

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Section: Discussionmentioning

confidence: 84%

“…Pomegranate extracts and punicalagin (its major component) have massive anti-diabetic, anti-inflammatory, antioxidant and anti-tumoral properties, both in vivo and in vitro [12,13]. In addition, consumption of green tea has been associated with decreased risks of obesity, diabetes and hypertension [14].…”

Section: Introductionmentioning

confidence: 99%

Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice

et al. 2014

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“…For example a reaction of glyoxal with lysine residues produces CML, which is considered as an ALE or AGE compound [13]. Plant phenolic compounds such as punicalagin, ellagic acid, anthocyanins, oleanolic acid, ursolic acid, or gallic acid, which can all be found in pomegranate [92] have shown a lipid oxidation inhibitory activity by scavenging free radicals [93]. Phytochemicals such as oleanolic acid and ursolic acid in pomegranate flower extracts have shown antihyperlipidemic activities [92].…”

Section: Antilipoxidation Propertiesmentioning

confidence: 99%

“…Plant phenolic compounds such as punicalagin, ellagic acid, anthocyanins, oleanolic acid, ursolic acid, or gallic acid, which can all be found in pomegranate [92] have shown a lipid oxidation inhibitory activity by scavenging free radicals [93]. Phytochemicals such as oleanolic acid and ursolic acid in pomegranate flower extracts have shown antihyperlipidemic activities [92]. Plants with hypoglycemia activity such as T. foenum-graeceum seeds have the potential to ameliorate diabetic complication by decreasing triglyceride, serum cholesterol LDL (but not HDL) and finally AGEs formation [94].…”

Section: Antilipoxidation Propertiesmentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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“…Similarly, Kumar et al [16] indicated that pomegranate (Punica granatum) peel extract provides protection against mercuric chloride-induced oxidative stress in Wistar strain rats. It is also reported that pomegranate extracts have been found to have strong anti-inflammatory, antioxidant, and even antitumor properties in vivo and in vitro [17] .…”

Section: Discussionmentioning

confidence: 99%

Does Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?

Akdağ¹,

Daşdağ²,

Alabalık³

et al. 2014

Int Adv Otol

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OBJECTIVE:The aim of this study was to investigate the protective effect of short-term usage of fresh pomegranate juice (FPJ) on ototoxicity after cisplatin-based chemo-irradiation MATERIALS and METHODS:The study was carried out on 56 adult Wistar Albino rats, which were divided into 8 groups (n: 7 for each group). The first group was accepted as the sham control group. However, rats in the seven experimental groups were treated with FPJ; cisplatin; irradiation; irradiation plus FPJ; cisplatin plus FPJ; both cisplatin and irradiation; and combined use of cisplatin, irradiation, and FPJ, respectively. Ototoxicity was evaluated by Distortion Product Otoacoustic Emissions (DPOA), histopathology, and paracochlear protein carbonyl content. RESULTS:The results of the study showed that cisplatin, irradiation, and both cisplatin and irradiation treatments affected hair cells dramatically. However, the results of cisplatin plus FPJ and combined use of cisplatin, irradiation, and FPJ indicated that FPJ plays an important role in protecting hair cells in the inner ear. Additionally, the findings of signal-noise ratio and protein carbonyl values also supported the results stated above. CONCLUSION:Fresh pomegranate juice treatment can be a supportive agent to reduce hair cell injury in the inner ear of patient treated by cisplatin, radiotherapy, or cisplatin-based chemo-irradiation. However, more performance is necessary for further studies, especially on long-term treatment with FPJ.

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Obesity: The preventive role of the pomegranate (Punica granatum)

Cited by 146 publications

References 114 publications

Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice

Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

Does Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?

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