Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

Park, Hyelim; Shim, Seunghyun; Lee, Eun-Young; Cho, Whajung; Park, Sooho; Jeon, Hae Myung; Ahn, Sunyoung; Kim, Hun; Nam, Jae‐Hwan

doi:10.4161/hv.28332

Cited by 99 publications

(98 citation statements)

References 23 publications

(27 reference statements)

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“…13 Additionally, the results from a South Korea study indicated that the functions of memory T cell response may be impaired in obesity subjects because the titers of neutralizing antibodies in obese mice were more quickly decreased than those in the normal mice. 14 Another mechanism responsible for impaired immunization responses in obese individuals may be leptin-induced systemic and B cell intrinsic inflammation. 15 Leptin is produced by fat cells and can modulate both innate and adaptive immune responses.…”

Section: Discussionmentioning

confidence: 99%

Influences of obesity on the immunogenicity of Hepatitis B vaccine

Liu¹,

Guo

Dong

2017

Human Vaccines & Immunotherapeutics

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Objective: Hepatitis B vaccine is regarded as the most effective method for the prevention of hepatitis B virus (HBV) infection. However, several factors such as age, body mass index and immunocompetent state have been reported to be associated with reduced immunization responses. The present commentary was aimed to discuss the influences of obesity on the immunogenicity of hepatitis B vaccines. Data sources: Available peer-reviewed literatures, practice guidelines, and statistics published on hepatitis B vaccine in obesity between 1973 and 2015. Conclusions: Obesity was significantly associated with non-response to hepatitis B vaccine immunization. The risk of nonresponsiveness of hepatitis B vaccine among obese people increased with BMI. Moreover, the obesity might lead to an increased risk of HBV vaccine-escape mutations. The mechanism responsible for decreased immunization responses in obesity included leptininduced systemic and B cell intrinsic inflammation, impaired T cell responses and lymphocyte division and proliferation. Therefore, more studies should be performed to analyze the influences of obesity on the immunogenicity of hepatitis B vaccines to improve the immunoprotecive effect of hepatitis B vaccines in future.

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Section: Discussionmentioning

confidence: 99%

Influences of obesity on the immunogenicity of Hepatitis B vaccine

Liu¹,

Guo

Dong

2017

Human Vaccines & Immunotherapeutics

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“…This accelerated immune aging phenotype has even been noted in obese children [23]. In line with this, obesity has been found to lead to poor vaccination responses [24,25]. A number of studies have examined the impact of obesity on immune challenge, with conflicting results.…”

Section: Effects Of Obesity On the Immune Systemmentioning

confidence: 96%

Obesity induced T cell dysfunction and implications for cancer immunotherapy

Aguilar

Murphy

2018

Current Opinion in Immunology

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Obesity has been shown to increase risk for a number of different disorders, including cancer. In addition, obesity is also associated with immune dysfunction, which could contribute to its strong association with other comorbidities. Recently, the immune system has been found to be heavily regulated by changes in metabolism. In particular, T cells are able to respond to intrinsic metabolic regulatory mechanisms, as well as extrinsic factors such as the changes in metabolite availability. The dysfunctional metabolic environment created by obesity could therefore have a direct impact on T cell responses. In this review, we highlight recent findings in the fields of T cell biology and obesity, with a focus on mechanisms driving T cell dysfunction and potential implications for immunotherapeutic treatment of cancer.

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“…In particular, it has been demonstrated that mice fed a high fat diet (HFD) had lower levels of neutralizing antibody titers, higher serum levels of the monocyte chemotactic protein MCP-1 and lower percentages of influenza virus-specific effector memory CD8+ T cells, as compared to control mice. Moreover, after challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of control mice, even after vaccination, suggesting that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination (Park et al 2014). …”

Section: Aging and Inflammation Decrease Antibody Responses In Mice Amentioning

confidence: 99%

Inflammaging decreases adaptive and innate immune responses in mice and humans

2015

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Both the innate and adaptive immune systems decline with age, causing greater susceptibility to infectious diseases and reduced responses to vaccination. Diseases are more severe in elderly than in young individuals and have a greater impact on health outcomes such as morbidity, disability and mortality. Aging is characterized by increased low-grade chronic inflammation, called “inflammaging”, measured by circulating levels of TNF-α, IL-6 and CRP, as well as by latent infections with viruses such as cytomegalovirus (CMV). Inflammaging has received considerable attention because it proposes a link between changes in immune cells and a number of diseases and syndromes typical of old age. In this review we aim at summarizing the current knowledge on pathways contributing to inflammaging, on immune responses down-regulated by inflammation and mechanisms proposed. The defects in the immune response of elderly individuals presented in this review should help to discover avenues for effective intervention to promote healthy aging.

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Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

Cited by 99 publications

References 23 publications

Influences of obesity on the immunogenicity of Hepatitis B vaccine

Influences of obesity on the immunogenicity of Hepatitis B vaccine

Obesity induced T cell dysfunction and implications for cancer immunotherapy

Inflammaging decreases adaptive and innate immune responses in mice and humans

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