Inflammaging decreases adaptive and innate immune responses in mice and humans

Frasca, Daniela; Blomberg, Bonnie B.

doi:10.1007/s10522-015-9578-8

Cited by 287 publications

(252 citation statements)

References 114 publications

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“…[ 71,72 ] per se, aging is considered one of the main contributors to aberrant wound healing. In addition, age-associated systemic diseases further impair the skin's wound healing capacity.…”

Section: Clinical Features Of Chronic Wounds In the Elderlymentioning

confidence: 99%

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Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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Summary The elderly constitute the age group most susceptible to wound healing disorders and chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic foot ulcers. However, other age‐associated diseases should also be taken into consideration in the diagnostic workup of chronic wounds, and not be underestimated. A better understanding of the pathomechanisms involved in the wound healing process is of key importance in combatting the difficulties associated with the treatment of chronic wounds. In recent decades, considerable progress has been made in the development of pioneering therapeutic strategies for chronic wounds. In this context, the use of growth factors and cytokines, tissue engineering, and cell therapy – including stem cells – have proven very promising. Nevertheless, prior to their introduction into routine clinical practice, large controlled clinical trials are required to assess the safety of these techniques.

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Section: Clinical Features Of Chronic Wounds In the Elderlymentioning

confidence: 99%

“…Given that basal cell carcinoma and squamous cell carcinoma may clinically present as leg ulcers, it is imperative that a neoplastic ulcer be ruled out ( Figure 5 ) [ 72 ] . In rare cases, malignant transformation of chronic wounds may also occur (Marjolin's ulcer).…”

Section: -Mycosis -Bacterial and Viral Infections -Protozoamentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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“…Alterations in both innate and adaptive immune cells in the aged have been noted 2,3 . In brief, the age-dependent effects on the innate immune response include diminished pathogen recognition, chemotaxis, and phagocytosis, and in adaptive immunity, declining numbers of naïve T lymphocytes and reduced cytotoxicity and antibody quality and quantity 2 . Vaccine efficacy is reduced in the elderly, as are increases in autoimmunity and cancer 2 .…”

Section: Introductionmentioning

confidence: 99%

Inflammaging and the Lung

Kovacs

Boe

Boule

et al. 2017

Clinics in Geriatric Medicine

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SYNOPSIS With the coming of the “Silver Tsunami,” expanding our knowledge about how a variety of intrinsic and extrinsic factors affect the immune system in the elderly is both timely and of immediate clinical need. It is clear that the global population is increasing in age. By the year 2030, over 20% of the population of the United States will be over 65 years of age. In this chapter, we will focus on how advanced age alters the immune systems and how this, in turn, modulates the ability of the aging lung to deal with the infectious challenges from both the outside world and from within the host.

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“…Chronic inflammation strongly affects the pathogenesis of chronic and age-related diseases. With increasing age there is an enhanced incidence of a low level chronic inflammation in the absence of infection which is called inflammaging [26,27]. Among other cytokines, in particular interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha) levels are elevated in this state.…”

Section: Introductionmentioning

confidence: 99%

EGCG Containing Combined Dietary Supplement Affects Telomeres and Epigenetic Regulation

Pointner¹,

Magnet²,

Tomeva³

et al. 2017

J Nutr Food Sci

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Objective: In vitro and in vivo studies in rodents have demonstrated many health promoting properties of individual phytochemicals including antioxidative and chemopreventive effects. Recently combination of substances is claimed to enhance activity.The objective of this study was to investigate health benefits of a daily consumption of a combination of a large variety of phytochemicals (TimeBlock ® ). To assess potential changes we analyzed specific biomarkers that are associated with aging, oxidative stress and DNA stability: Methylation of LINE-1, c-Myc, IL-6, MLH1, DNMT1, ITGA2B and telomere length. Methods:For this study 110 healthy participants of both sexes between 31-76 years were recruited, 101 subjects were included in further analysis. A small reference group (n=20) without intervention within the same age interval served as control. Participants received a plant based dietary supplement (TimeBlock ® ) for 6 months by oral administration. Ingredients included extracts from green tea (EGCG), wheatgrass (tocotrienols), barley grass (folic acid), tomatoes (lycopene), tagetes (zeaxanthin, lutein), algae, shiitake mushrooms (vitamin D) and grape seeds (resveratrol). Capillary blood samples were collected from all participants before administration and within 6 days after the end of the study period following DNA extraction, bisulfite conversion and qPCR as well as high resolution melting curve analysis addressing analysis of LINE-1, c-Myc, IL-6, MLH1, DNMT1, ITGA2B and telomere length. Nutrition, lifestyle and health status were assessed with a standardized food and lifestyle questionnaire. Results and discussion:Our results confirmed the positive effect of plant derived antioxidants on telomeres and inflammation frequency. An age-specific drift of analyzed markers could be observed. While methylation of c-Myc-a key factor in telomerase regulation-was not affected by administration, total telomere length showed a significant increase, which we suggest to be linked with an increased cell turnover and accelerated apoptosis of senescent or mutated cells without enhancing telomerase activity. Further, methylation of mismatch repair protein gene MLH1 showed a strong negative correlation with telomere length, supporting the influence of MMR on telomere regulation. Conclusion:The results of the present study indicate that a combined administration of a variety of phytochemicals can be a potential preventive and therapeutic agent, as each substance exhibits different modes of action and in combination, health promoting effects could be potentiated. Addressing different mechanisms of aging, specific phytochemicals could be used as new therapeutic approach against age-related diseases.

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Inflammaging decreases adaptive and innate immune responses in mice and humans

Cited by 287 publications

References 114 publications

Pathogenesis of wound healing disorders in the elderly

Pathogenesis of wound healing disorders in the elderly

Inflammaging and the Lung

EGCG Containing Combined Dietary Supplement Affects Telomeres and Epigenetic Regulation

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