Obesity, bariatric surgery and oxidative stress

Abstract

Introduction: Obesity refers to the accumulation of fatty tissues and it favors the occurrence of oxidative stress. Alternatives that can contribute to body weight reduction have been investigated in order to reduce the production of reactive oxygen species responsible for tissue damage. The aim of the current study was to assess whether the oxidant and antioxidant markers of obese women before and after bariatric surgery were able to reduce oxidative damage. Method:We have assessed 16 morbidly obese women five days before and 180 days after the surgery. The control group comprised 16 non-obese women. Levels of thiobarbituric acid-reactive substances, carbonylated proteins, reduced glutathione and ascorbic acid were assessed in the patients' plasma. Results: Levels of lipid peroxidation and protein carbonylation in the pre-surgical obese women were higher than those of the controls and post-surgical obese women. Levels of reduced glutathione in the pre-surgical obese women were high compared to the controls, and declined after surgery. Levels of ascorbic acid fell in the pre--surgical obese women compared to the control and post-surgical obese women. Conclusion: Body weight influences the production of reactive oxygen species. Bariatric surgery, combined with weight loss and vitamin supplementation, reduces cellular oxidation, thus reducing tissue damage.

One Anastomosis Gastric Bypass Reconstitutes the Appropriate Profile of Serum Amino Acids in Patients with Morbid Obesity

“…AABA activates AMP-kinase (AMPK) and increases intracellular glutathione levels, thus protecting against oxidative stress [25]. Oxidative stress is, in principle, significantly increased in obesity and decreases after BS [26,27], similar to the concentration of AABA (Table 2), which suggests its role in the regulation of oxidative stress associated with obesity. Additionally, the levels of DL-3-aminobutyric acid (BABA) were higher before OAGB than after OAGB.…”

Decreased Chromosomal Damage in Lymphocytes of Obese Patients After Bariatric Surgery

“…Billeter and colleagues 31 demonstrated a significant reduction of insulin resistance, leptin values, inflammation and oxidative stress 24 months after bariatric surgery. Horn and colleagues 32 also showed reduced oxidative stress in 16 obese women 180 days after bariatric surgery. The average BMI of the participants was 44.1 ± 6.8 kg/m 2 before surgery.…”

Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery

“…Obese women were found to have higher plasmatic concentrations of lipid peroxidation and protein carbonylation markers, compared with normal-weight controls. When measured 6 months after bariatric surgery, the levels of these markers were significantly reduced, although the concentrations did not reach those of the control group [69]. Short-term outcomes after biliopancreatic diversion have demonstrated an increase in glutathione-S-transferase and glutathione reductase activity in plasma, despite a decrease in glutathione peroxidase activity.…”