Obesity and cancer

Calle, Eugenia E.; Thun, Michael J.

doi:10.1038/sj.onc.1207751

Cited by 615 publications

(380 citation statements)

References 135 publications

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“…obstructive sleep apnoea and asthma), and neoplasia (e.g. breast, prostatic, ovarian, colonic/rectal, renal cell and oesophageal cancer (2)(3)(4)(5) . Not surprisingly, obesity conveys increased risk of mortality to affected human subjects (6) .…”

Section: The Significance Of Obesity In Petsmentioning

confidence: 99%

Outcomes of weight management in obese pet dogs: what can we do better?

German

2016

Proc. Nutr. Soc.

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Obesity is arguably the biggest health and welfare issue affecting pet dogs. Although successful weight loss has health benefits, current strategies are far from ideal. Many obese dogs that start a weight programme fail to lose weight, or subsequently regain the weight they have lost. Given that current weight loss strategies are not perfect, clinicians need to focus carefully on tailoring the programme, perhaps setting a pragmatic target for weight loss, so as to ensure the benefits are maximised. This review will summarise key findings from recent clinical research into pet obesity, and present a framework for improving success, by better tailoring weight management regimens and end points to the individual.

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Section: The Significance Of Obesity In Petsmentioning

confidence: 99%

Outcomes of weight management in obese pet dogs: what can we do better?

German

2016

Proc. Nutr. Soc.

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“…It is likely that the relationship between body composition and morbidity is multifactorial. Lifestyle, diet and genetic factors probably contribute to the adverse health effects of obesity, and fat tissue may theoretically act as a storage reservoir for toxins that could contribute to the pro-carcinogenic effects of obesity (Calle and Thun, 2004).…”

Section: Introductionmentioning

confidence: 99%

Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation

Ogunwobi

Beales

2008

Molecular and Cellular Endocrinology

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Obesity increases the risk of developing several cancers including oesophageal adenocarcinoma (OAC). Obesity is characterized by hyperleptinaemia and hypoadiponectinaemia: we have hypothesized that these hormonal factors may contribute to the progression of OAC. We have examined the effects of leptin and adiponectin on proliferation of OAC cells. Leptin stimulated proliferation in 4 different OAC lines (OE33, OE19, BIC-1 and FLO) and this was inhibited by globular but not full length adiponectin. All 4 OAC lines expressed both adiponectin-receptor isoforms (AdipoR1 and AdipoR2).

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“…Recent data from the Family Budget Survey, carried out between 2008 and 2009, showed that in Brazil obesity affects approximately 14 % of adults over the age of 20 years (2) . Obesity is linked to many adverse health outcomes, including diabetes, CVD, cancer and overall mortality (3)(4)(5)(6) . Traditionally, causes of obesity have been linked to the imbalance between energy intake and physical activity (7) .…”

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confidence: 99%

Sleep deprivation and obesity in shift workers in southern Brazil

Canuto

Pattussi

Macagnan

et al. 2013

Public Health Nutr.

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Objective: The objective of our study was to explore the association between sleep deprivation and obesity among shift workers. Design: A cross-sectional study was conducted. Obesity was defined as BMI $30 kg/m 2 . Time of sleep was categorized as: .5 h of continuous sleep/d; #5 h of continuous sleep/d with some additional rest (sleep deprivation level I); and #5 h of continuous sleep/d without any additional rest (sleep deprivation level II). Sociodemographic, parental and behavioural variables were evaluated by means of a standardized pre-tested questionnaire. Potential confounding factors were controlled for in the multivariable model. Setting: A poultry-processing plant in southern Brazil. Subjects: Nine hundred and five shift workers (63 % female). Results: Obesity was more prevalent in the participants who were female, aged 40 years and older, who had less schooling and reported excess weight in both parents. Sleep deprivation levels I and II were associated with increased income, number of meals consumed throughout the day and nightshift work. All of the workers who exhibited a degree of sleep deprivation worked the night shift. After controlling for potential confounding factors, the prevalence ratios of obesity were 1?4 (95 % CI 0?8, 2?2) and 4?4 (95 % CI 2?4, 8?0) in the workers with sleep deprivation levels I and II, respectively, compared with the reference group. Conclusions: These results show a strong association between sleep deprivation and obesity in shift workers and that sleep deprivation may be a direct consequence of working at night.

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Obesity and cancer

Cited by 615 publications

References 135 publications

Outcomes of weight management in obese pet dogs: what can we do better?

Outcomes of weight management in obese pet dogs: what can we do better?

Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation

Sleep deprivation and obesity in shift workers in southern Brazil

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