O28 Changing epidemiology of methicillin-resistant Staphylococcus au-reus in Alberta, Canada: population-based surveillance 2005–2008

Kim, J.; Ferrato, Christina; Simmonds, K.; Chui, Linda; Mulvey, Matthew A.; Golding, George R.; Svenson, L.; Louie, Marie

doi:10.1016/s0924-8579(09)70175-x

Cited by 6 publications

(12 citation statements)

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“…MRSA isolated from sentinel Canadian acute care sites from 1995 to 2007 showed USA300/CMRSA10 as the second most commonly isolated clone (27 % of isolates), with the majority seen in Western Canada [ 3 ]. An Alberta study from 2005 to 2008 confirmed this increase in USA400/CMRSA7 and USA300/CMRSA10 clones: the highest rates of USA300/CMRSA10 were reported in people aged 25–44, while highest rates of USA100/CMRSA2 were seen in patients >65 years [ 4 ]. The distribution of the most commonly isolated spa types were t002, t008, and t128 and they belonged to PFGE epidemic types USA100/CMRSA2, USA300/CMRSA10, and USA400/CMRSA7 respectively [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…An Alberta study from 2005 to 2008 confirmed this increase in USA400/CMRSA7 and USA300/CMRSA10 clones: the highest rates of USA300/CMRSA10 were reported in people aged 25–44, while highest rates of USA100/CMRSA2 were seen in patients >65 years [ 4 ]. The distribution of the most commonly isolated spa types were t002, t008, and t128 and they belonged to PFGE epidemic types USA100/CMRSA2, USA300/CMRSA10, and USA400/CMRSA7 respectively [ 4 ]. Our data were similar with t002 (31.6 % of all spa types), t008 (29.3 %), t003 (7.5 %) and t128 (4.8 %) being the predominant spa types.…”

Section: Discussionmentioning

confidence: 99%

“…A core function of the Provincial Laboratory for Public Health (ProvLab) is laboratory surveillance, which includes the identification of emerging problems, reporting strategies, dissemination of information and other intervention programs for infectious diseases. MRSA is a notifiable pathogen in Alberta and molecular typing of first clinical MRSA isolate in a patient in the preceding 12 months has been performed at the ProvLab since June 2005 [ 4 ]. Historically, MRSA typing in Alberta has used pulsed-field gel electrophoresis (PFGE) types however in March 2010 Staphylococcus aureus protein A ( spa ) typing was implemented, with standardized nomenclature that allows for easy international comparisons [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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The molecular epidemiology of incident methicillin-resistant Staphylococcus aureus cases among hospitalized patients in Alberta, Canada: a retrospective cohort study

Bush

Leal

Fathima

et al. 2015

Antimicrob Resist Infect Control

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BackgroundInfection Prevention and Control (IPC) surveillance for incident methicillin-resistant Staphylococcus aureus (MRSA) in hospitalized patients is performed in a complete provincial surveillance network of all acute care facilities in Alberta, Canada. IPC surveillance is centralized using a web-based data entry platform so that each patient is counted only once. All diagnostic laboratories submit the first clinical MRSA isolate associated with a patient without previous MRSA positive clinical cultures in the preceding year to the Provincial Laboratory for Public Health (ProvLab) for molecular typing. This study will investigate the relationship between the IPC epidemiological classification based on time of detection following admission to hospital (Hospital Acquired and Community Associated) and the matched laboratory MRSA surveillance data using a retrospective cohort study design.MethodsIncident IPC MRSA cases were classified according to IPC epidemiologic definitions. DNA sequencing of the Staphylococcus protein A (spa) gene and pulsed-field gel electrophoresis (PFGE) typing was performed. IPC MRSA surveillance data were matched to the ProvLab molecular surveillance data. Univariate comparisons of proportions were performed for categorical variables and the Student’s t test for continuous variables.ResultsMRSA molecular typing data were available for matching for 46.7 % (2248/4818) of incident IPC cases. There was agreement in definitions for traditional nosocomial clones (USA100/CMRSA2) with Hospital Acquired (HA)-MRSA (65.1 % of all IPC HA-MRSA) and traditional community clones (USA400/CMRSA7 and USA300/CMRSA10) with Community Acquired (CA)-MRSA (62.4 % of CA-MRSA). However, we observed discordance for both traditional nosocomial/CA-MRSA (30.4 % of CA-MRSA) and for traditional community/HA-MRSA (26.9 % of HA-MRSA).ConclusionsWe note agreement between traditional nosocomial clones and HA-MRSA, and traditional community clones and CA-MRSA. However, approximately one-quarter of HA-MRSA are those of traditional community clones while approximately one-third of CA-MRSA are those of traditional nosocomial clones. Collaborative provincial MRSA surveillance is important as the distinction between IPC case attribution in acute care settings and the historical definitions of MRSA clones as community- or healthcare-associated have blurred.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The molecular epidemiology of incident methicillin-resistant Staphylococcus aureus cases among hospitalized patients in Alberta, Canada: a retrospective cohort study

Bush

Leal

Fathima

et al. 2015

Antimicrob Resist Infect Control

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“…The USA100/CMRSA2 clone resembles HA-MRSA seen in other studies, consisting of an older population with more urinary infections reported [10, 12]. The distribution of USA400/CMRSA7 and USA300/CMRSA10 within the HA-MRSA population resembles that of community-acquired (CA) MRSA in the province [4, 21]. MRSA clones traditionally considered as community type resemble those described for community-identified MRSA; predominately affecting younger populations with fewer comorbidities and more likely to present with skin and soft tissue infections [10, 12].…”

Section: Discussionmentioning

confidence: 69%

“…In Canadian hospitals, the 2009 incident MRSA infection rate was 3·8/10 000 patient-days [2]. MRSA is also reported in the general community, where population MRSA infection rates were 10·7/10 000 population in 2009 [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Comparing the epidemiology of hospital-acquired methicillin-resistant Staphylococcus aureus clone groups in Alberta, Canada

et al. 2016

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Patients with methicillin-resistant Staphylococcus aureus (MRSA) clones, which were traditionally seen in the community setting (USA400/CMRSA7 and USA300/CMRSA10), are often identified as hospital-acquired (HA) infections using Infection Prevention and Control (IPC) surveillance definitions. This study examined the demographics and healthcare risk factors of patients with HA-MRSA to help understand if community MRSA clones are from a source internal or external to the hospital setting. Despite USA300/CMRSA10 being the predominant clone in Alberta, hospital clones (USA100/CMRSA2) still dominated in the acute care setting. In the Alberta hospitalized population, patients with USA400/CMRSA7 and USA300/CMRSA10 clones were significantly younger, had fewer comorbidities, and a greater proportion had none or ambulatory care-only healthcare exposure. These findings suggest that there are two distinct populations of HA-MRSA patients, and the patients with USA400/CMRSA7 and USA300/CMRSA10 clones identified in hospital more greatly resemble patients affected by those clones in the community. It is possible that epidemiological assessment overidentifies HA acquisition of MRSA in patients unscreened for MRSA on admission to acute care.

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A population-based study of the epidemiology and clinical features of methicillin-resistant Staphylococcus aureus infection in Pennsylvania, 2001–2010

et al. 2012

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SUMMARY No U.S. general population-based study has characterized the epidemiology and risk factors, including skin and soft tissue infection (SSTI), for healthcare-associated (HA) and community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA). We estimated the incidence of HA and CA-MRSA and SSTI over a 9-year period using electronic health record data from Geisinger Clinic in Pennsylvania. MRSA cases were frequency matched to SSTI cases and controls in a nested case-control analysis. Logistic regression was used to assess risk factors, while accounting for antibiotic administration. We identified 1713 incident CA and 1506 HA MRSA cases and 78216 SSTI cases. On average, from 2005–2009, the annual incidence of CA MRSA increased by 34%, HA-MRSA by 7%, and SSTI by 4%. Age, season, community socioeconomic deprivation, obesity, smoking, prior SSTI, and antibiotic administration were identified as independent risk factors for CA-MRSA.

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O28 Changing epidemiology of methicillin-resistant Staphylococcus au-reus in Alberta, Canada: population-based surveillance 2005–2008

Cited by 6 publications

References 0 publications

The molecular epidemiology of incident methicillin-resistant Staphylococcus aureus cases among hospitalized patients in Alberta, Canada: a retrospective cohort study

The molecular epidemiology of incident methicillin-resistant Staphylococcus aureus cases among hospitalized patients in Alberta, Canada: a retrospective cohort study

Comparing the epidemiology of hospital-acquired methicillin-resistant Staphylococcus aureus clone groups in Alberta, Canada

A population-based study of the epidemiology and clinical features of methicillin-resistant Staphylococcus aureus infection in Pennsylvania, 2001–2010

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