O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka, Silvia Alves; Perin, Eduardo Aliende; Sampaio, Aline Santos; Cordeiro, Quirino; Cappi, Carolina; Mastrorosa, Rosana Sávio; Morais, Ivanil A.; Reis, Viviane Neri de Souza; Rosário, Maria Conceição do; Hounie, Ana Gabriela

doi:10.1590/s0101-60832011000100008

Cited by 4 publications

(1 citation statement)

References 114 publications

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“…In relation to allele frequencies, our findings showed higher frequencies of 3R and 4R compared to other genotypes. This is consistent with earlier studies that present these as the most frequent alleles [2,19,25,29,30,[42][43][44].…”

Section: Discussionsupporting

confidence: 93%

The MAOA VNTR polymorphism and smoking behavior in Brazilian males

Mota¹,

Mitri²,

Barata-Silva³

et al. 2017

Biomed Genet Genomics

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Introduction: Tobacco smoking represents the leading preventable cause of morbidity and mortality in adults. Nicotine is responsible for tobacco addiction and is known to elevate brain dopamine, leading to feelings of pleasure and reward. The MAOA enzyme is responsible for degrading dopamine. It is known that a polymorphism in the promoter region of the MAOA gene has been implicated in smoking behavior. In this study, we investigated the association between the MAOA VNTR polymorphism and smoking behavior in Brazilian males. Methods:A cross-sectional study was conducted with 121 Brazilian males over 18 years of age. The polymorphism was genotyped using PCR. Multiple logistic regression were used to verify the association of MAOA gene polymorphisms with smoking status. Results:We not found significant association between the MAOA polymorphism and smoking status. Likewise, no association of the VNTR polymorphism with elements of smoking behavior, such as smoking duration, smoking initiation, relapses, smoking cessation, and degree of nicotine dependence, was observed. Conclusions:In conclusion, no association was observed between the MAOA polymorphism, smoking status and smoking behavior in population of Brazilian males studied. Further studies with larger sample sizes will be needed to elucidate these issues.

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Section: Discussionsupporting

confidence: 93%

The MAOA VNTR polymorphism and smoking behavior in Brazilian males

Mota¹,

Mitri²,

Barata-Silva³

et al. 2017

Biomed Genet Genomics

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Sexual dimorphic effect in the genetic association of monoamine oxidase A (MAOA) markers with autism spectrum disorder

Verma

Chakraborti

Karmakar

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Associação entre polimorfismos genéticos e transtorno bipolar

Alves¹,

Silva²,

Neto³

et al. 2012

Rev. psiquiatr. clín.

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Bipolar disorder (BD) is a common disorder that affects approximately 1% of the population. It is associated with both chronic and acute severe features, such as low remission rates and a high prevalence of clinical and psychiatric comorbidities. The aim of the present article is to synthesize data from various articles that investigated genetic polymorphisms associated with BD. The 129 articles selected identified 79 (85.87%) genes associated with BD. This analysis identified the five genes that are the most cited in the literature: CANAC1C, DAOA, TPH2, ANK3 and DISC1. Of the 92 genes identified in these articles, 33 (35.87%) showed no association with BD. This analysis showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD, further research is still required to elucidate its influence on this disorder.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Keywords: Bipolar disorder, genes, polymorphisms, heredity, gene ontology, association with bipolar disorder. ResumoTranstorno bipolar (TB) é uma doença comum que afeta aproximadamente 1% da população. Apresenta características crônicas e agudas graves, com índices de remissão de baixa e alta prevalência de comorbidades clínicas e psiquiátricas. O objetivo do presente artigo é sintetizar dados de vários artigos que investigaram polimorfismos genéticos associados com TB. Dentre os 129 artigos selecionados, identificaram-se 79 (85,87%) genes associados com TB. Essa análise identificou cinco genes que são os mais citados na literatura: CANAC1C, DAOA, TPH2, ANK3 e DISC1. Dos 92 genes identificados nesses artigos, 33 (35,87%) não mostraram associação com TB. Essa análise mostrou que, apesar dos avanços recentes com relação ao papel do polimorfismo genético na predisposição para TB, mais pesquisas ainda são necessárias para elucidar sua influência sobre esse transtorno.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Palavras-chave: Transtorno bipolar, genes, polimorfismos, hereditariedade, ontologia genética, associação com transtorno bipolar.

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O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Cited by 4 publications

References 114 publications

The MAOA VNTR polymorphism and smoking behavior in Brazilian males

The MAOA VNTR polymorphism and smoking behavior in Brazilian males

Sexual dimorphic effect in the genetic association of monoamine oxidase A (MAOA) markers with autism spectrum disorder

Associação entre polimorfismos genéticos e transtorno bipolar

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