Nutritional intervention in patients with Cystic Fibrosis: A systematic review

Woestenenk, J.W.; Castelijns, S.J.A.M.; Ent, Cornelis K. van der; Houwen, Roderick H. J.

doi:10.1016/j.jcf.2012.11.005

Cited by 32 publications

(25 citation statements)

References 25 publications

(198 reference statements)

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“…Due to their inability to absorb necessary micro and macronutrients, individuals with CF often take supplemental pancreatic enzymes and drastically increase their caloric intake (24). Even with extra supplementation, many individuals with CF remain chronically low in serum vitamin D levels either as a result of underlying complications and oxidative stress that increases the body's need or a poorly understood interaction between the CFTR and vitamin D transporters in the intestinal cells (25,26).…”

Section: Age and Sex Characteristicsmentioning

confidence: 99%

Dental utilization for Medicaid‐enrolled children with cystic fibrosis

Sarvas

Huebner

Scott

et al. 2016

Special Care in Dentistry

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Section: Age and Sex Characteristicsmentioning

confidence: 99%

Dental utilization for Medicaid‐enrolled children with cystic fibrosis

Sarvas

Huebner

Scott

et al. 2016

Special Care in Dentistry

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“…Nutrition interventions in patients with CF include behavioral approaches/interventions, oral supplementation, and enteral tube feedings 30 . Appetite stimulants are also commonly used.…”

Section: Nutrition Support In Cfmentioning

confidence: 99%

Nutrition Management of Cystic Fibrosis in the 21st Century

2015

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Despite significant advancements made in life expectancy over the past century, cystic fibrosis remains a life-threatening genetic disease that affects the gastrointestinal tract, and it has significant impact on the nutrition status of those with the disease. Nutrition management includes a high-calorie/high-fat diet, pancreatic enzyme replacement therapy, vitamin and mineral replacement, and enteral support as needed. As patients are living longer, clinicians may encounter patients with cystic fibrosis in obstetrician offices, endocrine clinics, or hospital settings, owing to lung transplantation or for treatment for distal intestinal obstruction syndrome.

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“…Patients who receive enteral nutrition show less weight loss and a lower risk of mortality and complications than patients at risk of malnutrition who receive normal feeding (3), and this type of nutritional intervention is particularly effective if started early (6). Enteral nutrition (EN) has been found to be beneficial in patients with a wide range of conditions, including burns, chronic obstructive pulmonary disease, gastrointestinal surgery or liver diseases (7,8). In addition, it has been shown to be safe and cost-effective and, since its introduction, it has become an established procedure (9).…”

Section: Introductionmentioning

confidence: 99%

The effects on nutritional status, bowel habits and tolerance of a high- protein, high-calorie, fiber- and fructo-oligosaccharide-enriched enteral formula: Safety and Effectiveness of Enteral Nutrition in Spanish patients (SENS Study).

et al. 2017

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on behalf of the SENS Working Group. The effects of a high-protein, high-calorie, fiber-and fructooligosaccharide-enriched enteral formula on nutritional status, bowel habits and tolerance: Safety and Effectiveness of Enteral Nutrition in elderly Spanish patients (SENS Study ResumenIntroducción: la nutrición enteral es una intervención efectiva para pacientes desnutridos o en riesgo de sufrir desnutrición. Sin embargo, puede desencadenar complicaciones como intolerancia gastrointestinal, hiperglicemia o síndrome de realimentación. Objetivo: investigar los efectos de una fórmula de nutrición enteral por sonda en el estado nutricional y bioquímico, hábitos gastrointestinales y seguridad de los pacientes. Metodología: estudio observacional, prospectivo y multicéntrico. Se incluyeron pacientes ≥ 18 años, desnutridos o en riesgo de desnutrición, tributarios de recibir una fórmula de nutrición enteral hipercalórica, hiperproteica, y rica en fibra y fructooligosacáridos. Los pacientes fueron evaluados durante 8 semanas en 3 visitas (V1, inicial; V2, 4 semanas; V3, 8 semanas). Resultados: entre V1 y V2 se observó un incremento estadísticamente significativo en peso (1,5 kg), índice de masa corporal (0,6 kg/m 2 ) e ingesta calórica (59,7 kcal/día). Entre V1 y V3, existió un descenso en el porcentaje de pacientes con valores anormales de glucosa, potasio, proteína total y albúmina. Los hábitos intestinales se mantuvieron estables durante el estudio (1,1 deposiciones diarias de media). Conclusión: la fórmula fue segura, tolerada, y mejoró el estado nutricional del paciente sin alterar los hábitos intestinales. AbstractBackground: Enteral nutrition (EN) is an effective nutritional intervention for patients at risk of malnutrition or malnourished. However, complications such as gastrointestinal intolerance, hyperglycemia or refeeding syndrome can be triggered by EN. Aim: To investigate the effects of a tube feeding formula (TFF) on patients' nutritional status, biochemical status, bowel habits and safety. Methodology: Observational, prospective and multicenter study. Patients ≥ 18 years, undernourished or at nutritional risk, who were prescribed a high-calorie, high-protein, fiber-fortified TFF were included. Patients were evaluated over a period of eight weeks (baseline [V1], four weeks [V2] and eight weeks [V3]). Results: A statistically significant increase in weight (1.5 kg), body mass index (0.6 kg/m 2 ) and nutritional intake (59.7 kcal/day) was observed between V1 and V2. Between V1 and V3, there was a statistically significant decrease in the percentage of individuals with abnormal biochemical markers for glucose, potassium, total protein and albumin. The number of patients' bowel movements remained stable throughout the study with a mean of 1.1 daily bowel movements. Conclusion: The TFF was safe and well tolerated, improving patients' nutritional status without altering patients' bowel habits.

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Nutritional intervention in patients with Cystic Fibrosis: A systematic review

Abstract: Enteral tube feeding is effective to improve nutritional status, while the described effects of behavioural intervention and oral supplementation are not consistent at present.

Cited by 32 publications

References 25 publications

Dental utilization for Medicaid‐enrolled children with cystic fibrosis

Dental utilization for Medicaid‐enrolled children with cystic fibrosis

Nutrition Management of Cystic Fibrosis in the 21st Century

The effects on nutritional status, bowel habits and tolerance of a high- protein, high-calorie, fiber- and fructo-oligosaccharide-enriched enteral formula: Safety and Effectiveness of Enteral Nutrition in Spanish patients (SENS Study).

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