Nutritional factors and progenitor cell differentiation

Polus, Anna; Grzybowska, J; Kieć‐Wilk, Beata; Balwierz, Adriana; Keijer, Jaap; Schmitz, Gerd

doi:10.1007/s12263-007-0032-7

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…On the other hand, modifications in Atp1b2, Edil3, and Astn1 during development lead to glial dysfunction [ 14 – 16 ]. Moreover, various studies on nutritional factor effects and progenitor cell differentiation included Ctnnd1, Fat4, and Cdh2 [ 17 – 19 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Patterns of Neurodevelopmental Preconditioning: A Study of the Effects of Antenatal Steroid Therapy in a Protein-Restriction Mouse Model

Velayo

Ito

Dong

et al. 2014

ISRN Obstetrics and Gynecology

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Introduction. Prenatal programming secondary to maternal protein restriction renders an inherent susceptibility to neural compromise in neonates and any addition of glucocorticosteroids results in further damage. This is an investigation of consequent global gene activity due to effects of antenatal steroid therapy on a protein restriction mouse model. Methods. C57BL/6N pregnant mice were administered control or protein restricted diets and subjected to either 100 μg/Kg of dexamethasone sodium phosphate with normosaline or normosaline alone during late gestation (E10–E17). Nontreatment groups were also included. Brain samples were collected on embryonic day 17 and analyzed by mRNA microarray analysis. Results. Microarray analyses presented 332 significantly regulated genes. Overall, neurodevelopmental genes were overrepresented and a subset of 8 genes allowed treatment segregation through the hierarchical clustering method. The addition of stress or steroids greatly affected gene regulation through glucocorticoid receptor and stress signaling pathways. Furthermore, differences between dexamethasone-administered treatments implied a harmful effect during conditions of high stress. Microarray analysis was validated using qPCR. Conclusion. The effects of antenatal steroid therapy vary in fetuses according to maternal-fetal factors and environmental stimuli. Defining the key regulatory networks that signal either beneficial or damaging corticosteroid action would result in valuable adjustments to current treatment protocols.

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Section: Discussionmentioning

confidence: 99%

Molecular Patterns of Neurodevelopmental Preconditioning: A Study of the Effects of Antenatal Steroid Therapy in a Protein-Restriction Mouse Model

Velayo

Ito

Dong

et al. 2014

ISRN Obstetrics and Gynecology

View full text Add to dashboard Cite

show abstract

“…[ 32 ] Nutrition promotes the proliferation and maintenance of the stem/progenitor cell population. [ 33 34 ] Nutrient therapy is effective and augments the effects of conventional hair therapy by stimulating and supporting hair growth.…”

Section: Introductionmentioning

confidence: 99%

Influence of nutrition, food supplements and lifestyle in hair disorders

Rajput

2022

Indian Dermatol Online J

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Genetic, androgenic, epigenetic, environmental, lifestyle, diet, and nutritional factors have influence over promoting or regulating inflammation, immunity, and genetic expression predisposing to hair loss. Oxidative stress is a major mediator for various mechanisms of hair loss, including the release of transforming growth factor-β ( TGF-β). Nutrients counter oxidative stress, repair cellular damage, support cellular functions, and restore hair growth. Nutrients can be synergistic or antagonistic. Covert subclinical nutritional deficiencies are common. Higher dose of nutrients does not mean higher efficiency but may reverse the benefits converting an antioxidant to become prooxidant. Nutrients do not work alone but are supported by accessory micronutrients which ensure biological utilization. Providing proper nutritional environment can neutralize free radicals and perpetuate active hair growth cycles.

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Nutritional factors and progenitor cell differentiation

Cited by 2 publications

References 27 publications

Molecular Patterns of Neurodevelopmental Preconditioning: A Study of the Effects of Antenatal Steroid Therapy in a Protein-Restriction Mouse Model

Molecular Patterns of Neurodevelopmental Preconditioning: A Study of the Effects of Antenatal Steroid Therapy in a Protein-Restriction Mouse Model

Influence of nutrition, food supplements and lifestyle in hair disorders

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