Nutritional content and the activities of l-Dopa (L-3,4-dihydoxyphenyalanine) from Mucuna pruriens L. DC seeds of Central Java accession

Rima,; Ishmayana, Safri; Malini, Desak Made; Soedjanaatmadja, Ukun M.S.

doi:10.1016/j.arabjc.2022.104390

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…contains more secondary metabolites and is more toxic to A. salina L. The high toxicity of 70% ethanol extract suggests that it contains a higher concentration of secondary metabolite components. 38 These results are consistent with phytochemical screening that 70% ethanol extract has a higher content of flavonoids. After the secondary metabolite components are absorbed, they are distributed throughout the larvae body, going to cause metabolic disorders.…”

Section: Toxicitysupporting

confidence: 89%

Optimization of Xanthine Oxidase Activity, Phytochemical Screening, Toxicity Assay, and Antigout Activity of Spatholobus littoralis Hassk. Extract

Rahminiwati¹,

Sianipar²,

Sutriah³

et al. 2023

Pharmacogn J.

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Introduction:A medicinal plant from Central Kalimantan, Spatholobus littoralis Hassk., with a local name bajakah tampala, has long been used to treat gout or uric acid disease. This study aimed to develop the optimum conditions of xanthine oxidase (XO) activity, phytochemical screening, and to obtain the antigout activity of S. littoralis Hassk. Methods: Before performing the phytochemical screening, we performed a simplicia maceration with water and 70% ethanol solvents. The development of the optimum conditions for XO was carried out using the Response Surface Methodology (RSM) combined Box-Behnken Design (BBD). Toxicity assay (LC 50 ) on both extracts was assessed by BSLT (Brine Shrimp Lethality Test). The two extracts were then evaluated for antigout activity. Results: The yield of 70% ethanol extract (11.24%) was higher than the aqueous extract (7.29%). The phytochemical screening on the simplicia and the two extracts positively contained steroids, flavonoids, saponins, and tannins. The optimum conditions of XO activity were temperature of 20 ℃, pH of 8.0, and xanthine concentration of 1.40 mM. The toxicity of the 70% ethanol extract (LC 50 662.25 mg/L) was stronger than the aqueous extract (LC 50 774.68 mg/L). Moreover, the 70% ethanol extract (IC 50 224.14±8.62 mg/L) showed higher XO inhibition than the water extract (IC 50 348.83±4.85 mg/L). Lineweaver-Burk plot analysis showed that 70% ethanol and water extracts inhibited XO competitively with the inhibition constant (K I ) of 272.68 mg/L and 378.44 mg/L, respectively. Conclusion: This preliminary study can be a reference that S. littoralis Hassk. is potentially an antigout.

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Section: Toxicitysupporting

confidence: 89%

Optimization of Xanthine Oxidase Activity, Phytochemical Screening, Toxicity Assay, and Antigout Activity of Spatholobus littoralis Hassk. Extract

Rahminiwati¹,

Sianipar²,

Sutriah³

et al. 2023

Pharmacogn J.

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“…Nusa Tenggara Timur (NTT) merupakan salah satu provinsi di Indonesia yang memiliki keragaman flora, termasuk keragamaman kacang-kacangan lokal yang telah banyak dilaporkan dalam berbagai publikasi ilmiah, terutama keragaman kacangan-kacangan, komposisi nutrisi dan pemanfaatannya di masyarakat. Kacangkacangan lokal yang banyak dijumpai di NTT antara lain: kedelai (Glycine max) (Bayero et al, 2019), kacang tanah (Arachis hypogaea) (Mafara, 2020), kacang hijau (Vigna radiata (L.) R. Wilczek) (Enyiukwu et al, 2020), kacang gude (Cajanus cajan), kacang nasi (Vigna unguiculata) (Puspita et al, 2017a), kacang arbila (Phaseolus lunatus) (Pramitha et al, 2021), kacang uci (Vigna umbellata) (Kaur et al, 2020), kacang komak (Lablab purpureus (L.) Sweet) (Kilonzi et al, 2017), kacang benguk (Mucuna pruriens (L.) DC) (Rima et al, 2023), kacang buncis (Phaseolus vulgaris L) (Anino et al, 2019), kacang kecipir (Psopocarpus tetragonolobus (L.) DC) (Adegboyega et al, 2020), dan kacang bitok (Pueraria montana var. lobata (Willd.)…”

Section: Pendahuluanunclassified

Local Legumes from Dry Land of East Nusa Tenggara: Diversity, Nutritional Composition, and Their Use in Society – A Literature Study

Naisali,

Witoyo,

Utoro

2023

JITIPARI

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East Nusa Tenggara (ENT) is a province in Indonesia with diverse flora, including the diversity of local legumes. It has been extensively explored and reported in various scientific publications, especially the types of legumes, their nutritional composition, and their uses in local communities. However, few literature studies still comprehensively review the types of legumes, their nutritional composition, and their utilization in the local community of ENT. So, this literature review aims to briefly review the diversity, chemical composition, and use of local legumes from the dry lands of ENT. Various studies reported that Glycine max, Arachis hypogaea, Vigna radiata (L.) R. Wilczek, Cajanus cajan, Vigna unguiculata, Phaseolus lunatus, Vigna umbellata, Lablab purpureus (L.) Sweet, Mucuna pruriens (L.) DC, Phaseolus vulgaris L, Psopocarpus tetragonolobus (L.) DC, and Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep nuts are commonly found in the ENT region, either cultivated by the local community or grown wild. Generally, local legumes in ENT have a relatively complete nutritional composition, which varies depending on the type of bean. The ENT's local people use local beans as a mixture of rice/corn and function as sources of protein. Future research is needed to explore the functional characteristics of each ENT local bean. In addition, it is necessary to develop formulations and other food products to utilize ENT's local legumes to diversify legume-based local food.

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“…The velvet bean cultivated in Indonesia referred to as koro benguk, is a local Indonesian bean that has yet to be widely known and utilized but has abundant nutritional content. Velvet bean contains protein (31.79 ± 1.64%), carbohydrate (54.75 ± 1.71%), fat (4.52 ± 0.12%), ash (3.38 ± 0.16%), and water (5.56 ± 0.21%) [7]. The seed extract contains 7.56% L-DOPA [8], which is a precursor of dopamine.…”

Section: Introductionmentioning

confidence: 99%

The potential of velvet bean tempe to improve hematology and serum biochemical profiles in experimental rats

Damayanti,

Astawan,

Wresdiyati

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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In Indonesia, tempe is the second largest source of protein after rice. The main raw material for tempe is soybean, of which 70% is still obtained through imports. This has encouraged the necessity to explore Indonesia’s indigenous legume products. Velvet bean (Mucuna pruriens L.) contains several bioactive components, is rich in minerals, and is composed of essential and non-essential amino acids, as well as essential and non-essential fatty acids. This study aimed to explore the potential of velvet beans as a substitute ingredient in tempe production. Parameters of serum biochemical profile and blood hematology of rats were used as scientific evidence that can support the purpose of this study. Protein quality was analyzed using the growth method in experimental rats. Three types of tempe were used as protein sources, namely soybean tempe (SBT), velvet bean tempe (VBT), and velvet bean-soybean combination tempe (VB-SBT). Protein quality analysis results show that VB-SBT has FCE, growth rate, and NPR values that were as good (p>0.05) as SBT. Analysis results of serum biochemical and hematological profiles indicate no abnormalities in rats fed with VB-SBT. These results suggest that the substitution of soybean with velvet bean can be applied in the tempe production process.

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Nutritional content and the activities of l-Dopa (L-3,4-dihydoxyphenyalanine) from Mucuna pruriens L. DC seeds of Central Java accession

Cited by 4 publications

References 39 publications

Optimization of Xanthine Oxidase Activity, Phytochemical Screening, Toxicity Assay, and Antigout Activity of Spatholobus littoralis Hassk. Extract

Optimization of Xanthine Oxidase Activity, Phytochemical Screening, Toxicity Assay, and Antigout Activity of Spatholobus littoralis Hassk. Extract

Local Legumes from Dry Land of East Nusa Tenggara: Diversity, Nutritional Composition, and Their Use in Society – A Literature Study

The potential of velvet bean tempe to improve hematology and serum biochemical profiles in experimental rats

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