Nutritional Aspects of Bone Health and Fracture Healing

Karpouzos, Athanasios; Diamantis, Evangelos; Farmaki, Paraskevi; Savvanis, Spyridon; Troupis, Theodore

doi:10.1155/2017/4218472

Cited by 67 publications

(58 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An appropriate dietary intake of calcium (Ca), as the principal component of bone, can significantly reduce bone loss and it is crucial to replenish daily Ca losses. When the Ca intake is insufficient, the organism is forced to increase the process of osteolysis to maintain homeostasis [26]. The obtained results confirmed that Ca dietary restriction (60% recommended dose) caused a significant decrease in ionized calcium, phosphorus concentration in serum, as well as the activity of alkaline phosphatase (bone turnover parameter).…”

Section: Discussionsupporting

confidence: 63%

The effect of fructan-enriched diet on bone turnover parameters in ovariectomized rats under calcium restriction

Topolska¹,

Bieńko²,

Filipiak‐Florkiewicz³

et al. 2020

Ann Agric Environ Med.

View full text Add to dashboard Cite

Introduction. Osteoporosis, the "quiet epidemic", is one of the most serious threats to public health. It is known that estrogen plays a significant role in the regulation of bone turnover, and its loss at menopause causes osteoporosis. Added to this, insufficient calcium intake accelerates bone mass loss, increasing the risk of fractures. Objective. The study aimed to answer the question whether a fructan-enriched diet could be helpful in preventing from disturbances in bone turnover caused by calcium restriction combined with ovariectomy-induced estrogen deficiency. The differences related to the kind of fructan and "matrix effect" of fructan action (form of addition) were also evaluated. Materials and method. The study was conducted using sham-operated (control groups) or ovariectomized (OVX) rats fed a calcium restricted diet. The treatment diets contained one of three fructan sources-Jerusalem artichoke, yacon and Beneo Orafti Synergy1-added alone or as an ingredient of strawberry sorbet, all in the amount providing 8% fructans. Analyses of biological material included: serum Ca, Mg and P concentrations, alkaline phosphatase activity (ALP), osteocalcin (OC) and C-telopeptide degradation products from type I collagen (CTX). Densitometric parameters of femora were also assayed. Results. Among markers of bone turnover, the ALP activity depended both on the kind of fructan and the form of addition. The highest value was shown in the OVX group fed a low-calcium diet, whereas administration of diet enriched with Jerusalem artichoke led to an almost 50% decrease in the value of this parameter. Dietary fructans also lowered the OC level. Feeding rats with diet containing sorbet enriched in yacon or Jerusalem artichoke resulted in a decrease of CTX, compared to the diet containing yacon alone or fructan formulation in both forms No significant differences were observed in densitometric parameters between treatment groups. Conclusions. The obtained findings suggest that fructan administration with a calcium-restricted diet might exert a positive effect on bone turnover parameters. Regarding the form of their addition, it is possible that other constituents of sorbets contributed to the fructan action. It remains open whether this impact would be significant over a longer period of time.

show abstract

Section: Discussionsupporting

confidence: 63%

The effect of fructan-enriched diet on bone turnover parameters in ovariectomized rats under calcium restriction

Topolska¹,

Bieńko²,

Filipiak‐Florkiewicz³

et al. 2020

Ann Agric Environ Med.

View full text Add to dashboard Cite

show abstract

“…We chose potential confounder candidates for evaluation according to the suggestions of the literature: gestational age, education years, adult height, lifelong physical activity, lifelong smoking history, and adulthood diet . Gestational age (in weeks) was recorded at the maternity hospital.…”

Section: Methodsmentioning

confidence: 99%

Body Mass Index Trajectories From Birth to Midlife and Vertebral Dimensions in Midlife: the Northern Finland Birth Cohort 1966 Study

et al. 2018

View full text Add to dashboard Cite

Vertebral fracture risk is higher among individuals with small vertebral dimensions. Obesity is a global health problem and may also contribute to bone size and fracture risk. In this work we report the association between life course body mass index (BMI) and vertebral cross-sectional area (CSA) in midlife. The Northern Finland Birth Cohort 1966 study with its 46-year follow-up provided the material for this study. A subsample of 780 individuals had attended lumbar magnetic resonance imaging (MRI) at the age of 46 years, and had records of objectively measured BMI from the ages of 0, 7, 15, 31, and 46 years. Of these, MRI-derived data on vertebral size was available for 682 individuals. We identified latent lifelong BMI trajectories by performing latent class growth modeling (LCGM) on the BMI data, and then used sex-stratified linear regression models to compare the identified trajectory groups in terms of midlife vertebral CSA. Gestational age, education years, adult height, lifelong physical activity, lifelong smoking history, and adulthood diet were assessed as potential confounders. Three distinct trajectory groups ("stable slim," "stable average," and "early onset overweight") were identified among both sexes. Comparisons to the stable slim trajectory revealed that vertebral CSA was significantly (p < 0.001) larger among the stable average and early onset overweight trajectories (69.8 and 118.6 mm 2 larger among men, 57.7 and 106.1 mm 2 larger among women, respectively). We conclude that lifelong BMI has a positive association with midlife vertebral size among both sexes. Future studies should characterize the mediating factors of this association.

show abstract

“…In young healthy patients, bone tissue shows high self-repair abilities. However, systematic factors, such as an increased age, disease or obesity can negatively affect bone regeneration [ 1 , 2 , 3 ]. Large defects due to heavy trauma, multiple fracture, infection, or tumor resection, are also disruptive for proper tissue healing [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering

Mende

Götzl

Kubo

et al. 2021

Cells

View full text Add to dashboard Cite

Bone regeneration is a complex process that is influenced by tissue interactions, inflammatory responses, and progenitor cells. Diseases, lifestyle, or multiple trauma can disturb fracture healing, which might result in prolonged healing duration or even failure. The current gold standard therapy in these cases are bone grafts. However, they are associated with several disadvantages, e.g., donor site morbidity and availability of appropriate material. Bone tissue engineering has been proposed as a promising alternative. The success of bone-tissue engineering depends on the administered cells, osteogenic differentiation, and secretome. Different stem cell types offer advantages and drawbacks in this field, while adipose-derived stem or stromal cells (ASCs) are in particular promising. They show high osteogenic potential, osteoinductive ability, and immunomodulation properties. Furthermore, they can be harvested through a noninvasive process in high numbers. ASCs can be induced into osteogenic lineage through bioactive molecules, i.e., growth factors and cytokines. Moreover, their secretome, in particular extracellular vesicles, has been linked to fracture healing. The aim of this review is a comprehensive overview of ASCs for bone regeneration and bone tissue engineering.

show abstract

Nutritional Aspects of Bone Health and Fracture Healing

Cited by 67 publications

References 64 publications

The effect of fructan-enriched diet on bone turnover parameters in ovariectomized rats under calcium restriction

The effect of fructan-enriched diet on bone turnover parameters in ovariectomized rats under calcium restriction

Body Mass Index Trajectories From Birth to Midlife and Vertebral Dimensions in Midlife: the Northern Finland Birth Cohort 1966 Study

The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering

Contact Info

Product

Resources

About