Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study

Abstract

SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested.

The health burden of non-communicable neurological disorders in the USA between 1990 and 2017

“…Previous studies have reported the association between high BMI and the risk of dementia. ( Arnoldussen et al , 2019 ; Bianchi et al , 2019 ; Gregorio et al , 2019 ; Nam et al , 2019 ). A new systematic review study indicates the essential role of nutrition in the pathogenesis and evolution of neurodegenerative diseases ( Bianchi et al , 2019 ).…”

A influência da alimentação no tratamento da doença de alzheimer

“…tálamo, e induziu inflamação em áreas formadoras de placa. A ingestão de vitamina B3 da dieta está inversamente associada à DA, tendo um efeito protetor no desenvolvimento da doença e no declínio cognitivo (GREGORIO et al, 2019).…”

“…Estudos relatam que pacientes com DA apresentam deficiências nutricionais de muitas vitaminas e minerais. As deficiências de micronutrientes podem resultar não apenas na perda de massa magra, declínio das funções imunológicas e aumento do risco de fraturas, mas também no dano oxidativo no cérebro e deficiências nos neurotransmissores, prejudicando a função cognitiva (GREGORIO et al, 2019).…”

“…A dieta dos pacientes deve conter níveis mais elevados de proteína e menor carboidrato desde o início do tratamento da doença, particularmente para manter os níveis de neurotransmissores como serotonina, adrenalina e dopamina. Os neurotransmissores precisam de alguns precursores, como triptofano, colina e tirosina, que estão presentes nos alimentos proteico (GREGORIO et al, 2019). Indivíduos portadores de DA normalmente encontra-se desnutrida.…”

A influência da alimentação no tratamento da doença de alzheimer / The influence of food in the treatment of alzheimer's disease

“…(MEDEIROS et al, 2016). apenas na perda de massa magra, declínio das funções imunológicas e aumento do risco de fraturas, mas também no dano oxidativo no cérebro e deficiências nos neurotransmissores, prejudicando a função cognitiva (GREGORIO et al, 2019).…”