Nutrition and Acne: Therapeutic Potential of Ketogenic Diets

Paoli, Antonio; Grimaldi, Keith; Toniolo, Luana; Canato, M.; Bianco, Antonino; Fratter, Andrea

doi:10.1159/000336404

Cited by 92 publications

(27 citation statements)

References 179 publications

(94 reference statements)

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“…Paoli et al . also supported the influence of various dietary components on the development of acne, focusing particularly on the role played by carbohydrates …”

Section: Discussionmentioning

confidence: 87%

“…These findings are also consistent with Smith et al ., who demonstrated that a low‐glycaemic‐load diet for 12 weeks decreased serum IGF‐1 levels and significantly improved acne. The study by Paoli et al . demonstrated that high‐glycaemic‐load diets aggravate acne, cause postprandial hyperinsulinaemia and increase serum levels of free IGF‐1.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

et al. 2016

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“…Paoli et al . also supported the influence of various dietary components on the development of acne, focusing particularly on the role played by carbohydrates …”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

et al. 2016

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“…Placebo‐controlled studies have demonstrated that high glycaemic load diets aggravate acne, result in postprandial hyperinsulinaemia and increase serum levels of free IGF‐1 . Epidemiological as well as clinical evidence confirmed that milk and other insulinotropic dairy products induce or aggravate acne .…”

Section: Western Diet Upregulates Insulin/igf‐1 Signallingmentioning

confidence: 99%

Potential role ofFoxO1 and mTORC1 in the pathogenesis ofWestern diet‐induced acne

Melnik

Zouboulis

2013

Experimental Dermatology

140

121

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Acne in adolescents of developed countries is an epidemic skin disease and has currently been linked to the Western diet (WD). It is the intention of this viewpoint to discuss the possible impact of WD-mediated nutrient signalling in the pathogenesis of acne. High glycaemic load and dairy protein consumption both increase insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) that is superimposed on elevated IGF-1 signalling of puberty. The cell's nutritional status is primarily sensed by the forkhead box transcription factor O1 (FoxO1) and the serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1). Increased IIS extrudes FoxO1 into the cytoplasm, whereas nuclear FoxO1 suppresses hepatic IGF-1 synthesis and thus impairs somatic growth. FoxO1 attenuates androgen signalling, interacts with regulatory proteins important for sebaceous lipogenesis, regulates the activity of innate and adaptive immunity, antagonizes oxidative stress and most importantly functions as a rheostat of mTORC1, the master regulator of cell growth, proliferation and metabolic homoeostasis. Thus, FoxO1 links nutrient availability to mTORC1-driven processes: increased protein and lipid synthesis, cell proliferation, cell differentiation including hyperproliferation of acroinfundibular keratinocytes, sebaceous gland hyperplasia, increased sebaceous lipogenesis, insulin resistance and increased body mass index. Enhanced androgen, TNF-α and IGF-1 signalling due to genetic polymorphisms promoting the risk of acne all converge in mTORC1 activation, which is further enhanced by nutrient signalling of WD. Deeper insights into the molecular interplay of FoxO1/mTORC1-mediated nutrient signalling are thus of critical importance to understand the impact of WD on the promotion of epidemic acne and more serious mTORC1-driven diseases of civilization.

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“…Since ketogenic diet (KD) was established in the 1920s to treat epilepsy [1], it has been under investigation for many years as a potential therapy for numerous other diseases, such as Parkinson's disease, Alzheimer's disease, acne, and diabetes [2][3][4][5][6]. In the context of tumor therapy, KD has been propounded to potentiate antitumor effects of chemotherapy or radiation and to simultaneously reduce needed dosages to increase the quality of life of patients [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Untargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models

Licha

Vidali

Aminzadeh-Gohari

et al. 2019

Preprint

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Ketogenic diet (KD) is getting in the focus as auxiliary cancer therapy, since it provides sufficient energy supply for healthy cells, while impairing energy production in tumor cells underlying the Warburg effect. Thereby, it can assist in inhibiting tumor growth and simultaneously counteract cachexia, which is frequently observed in cancer patients under chemotherapy. In order to provide molecular evidence for the proposed synergistic inhibition of tumor growth, we applied untargeted quantitative metabolome analysis on a breast cancer xenograft mouse model. Healthy mice and such bearing breast cancer xenografts and receiving chemotherapy were compared after treatment with control diet and KD. Metabolomic profiling was performed on plasma samples, applying high-performance liquid chromatography coupled to tandem mass spectrometry. Statistical analysis revealed metabolic fingerprints comprising numerous significantly regulated features in the group of mice bearing breast cancer. This fingerprint disappeared after treatment with KD, resulting in recovery to the metabolic status observed in healthy mice receiving control diet. Moreover, amino acid metabolism as well as fatty acid transport were found to be affected by both, the tumor and the applied KD. Our results provide clear evidence of a significant molecular effect of KD in the context of tumor growth inhibition.

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Nutrition and Acne: Therapeutic Potential of Ketogenic Diets

Cited by 92 publications

References 179 publications

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

Potential role ofFoxO1 and mTORC1 in the pathogenesis ofWestern diet‐induced acne

Untargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models

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