Nutrient intake in Italian obese patients: Relationships with insulin resistance and markers of non-alcoholic fatty liver disease

Ricci, Giorgio; Canducci, E.; Pasini, V.; Rossi, Angelo; Bersani, Gianluca; Ricci, E.; Alvisi, Vittorio

doi:10.1016/j.nut.2010.07.014

Cited by 29 publications

(33 citation statements)

References 23 publications

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“…In agreement with previous reports [7,13], HOMA-IR was observed in the majority (68%) of our obese patients. On the other hand, +ve BARD predicted liver fibrosis in 42% of our patients.…”

Section: Discussionsupporting

confidence: 94%

“…The current opinion is that hypercaloric foods with a high glycemic index induce IR and initialize the steps of liver damage (6,14). However, not only carbohydrates, but all inadequate nutrient intakes may play an important role in the onset and progression of hepatic and metabolic disorders [7,15]. The carbohydrate energy intake could not be considered excessive because it only slightly (17%) exceeded the RDA.…”

Section: Discussionmentioning

confidence: 99%

“…Ranging from 2 to 4, the score is associated with an odds ratio of 17 to predict liver fibrosis, with a negative predicted value close to 100% [4,5]. Although inadequate dietary habits in obesity are strongly related to the development of insulin resistance and liver dysfunction [6], few investigations have focused on the dietary habits in obese Italian subjects with the quantitative determination of nutrient intakes, and the relationships between dietary constituents and the development or progression of metabolic and liver disorders in obesity [7,8]. The aims of this study were to investigate the following aspects in an Italian group of obese patients: the prevalence of IR and positive BARD (score ≥2); the nutrient intakes by quantitative determination; the evaluation of the excessive or deficient, i.e.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Unbalanced Polyunsaturated Fatty Acid Intake on Obesity-related Metabolic and Hepatic Dysfunctions

Ricci¹,

Canducci²,

Guida³

et al. 2017

MCMR

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“…In agreement with previous reports [7,13], HOMA-IR was observed in the majority (68%) of our obese patients. On the other hand, +ve BARD predicted liver fibrosis in 42% of our patients.…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Unbalanced Polyunsaturated Fatty Acid Intake on Obesity-related Metabolic and Hepatic Dysfunctions

Ricci¹,

Canducci²,

Guida³

et al. 2017

MCMR

Self Cite

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“…Similarly, carbohydrate consumption was positively correlated with increased risk of hepatic fibrosis in an Italian cohort of 63 obese patients undergoing bariatric surgery. 25 This study was limited by the lack of histologic confirmation of fibrosis (the latter was determined using the NAFLD fibrosis score) and dietary measurements that were not validated. Lastly, Musso et al 27 compared the diet of 25 patients with histologically confirmed NASH to that of controls and found it to be rich in saturated fat, cholesterol and low in polyunsaturated fat, fiber, and antioxidant vitamins C and E. On the basis of these results, all 3 macronutrients (fat, carbohydrates, and protein) as well as the antioxidant vitamins C and E are associated with the development of NAFLD.…”

mentioning

confidence: 99%

The Role of Nutrients in the Development, Progression, and Treatment of Nonalcoholic Fatty Liver Disease

Mouzaki

Allard

2012

Journal of Clinical Gastroenterology

100

101

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in adults and children and is currently the third most common indication for liver transplantation in North America. Its pathogenesis is thought to be secondary to multiple "hits" derived from the dietary components, adipose tissue, immune system, and intestinal microbiota. Lack of physical activity may contribute as well. Nutrients may exert their effect directly or through alteration of the intestinal microbiota. Research focusing on specific dietary components predisposing to NAFLD has shown conflicting results. Total energy intake, and macronutrients, has been linked to the development of NAFLD. Fructose not only contributes to hepatic steatosis but may trigger inflammatory signals as well. Polyunsaturated fatty acids are thought to exert anti-inflammatory effects. The role of vitamins as well as minerals in this field is actively being investigated. In this review, we discuss the evidence-linking macronutrients (such as carbohydrates and fat in general and fructose, fiber, short chain fatty acids, polyunsaturated fatty, and choline specifically) and micronutrients (such as vitamin E and C and minerals) with the development and treatment of NAFLD. We also discuss the literature on physical activity and NAFLD.

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“…In Italian obese patients with BMIs ranging from 30.9 to 73.7 kg/m 2 , Ricci et al . [11] investigated the possible relationships between serum indicators of fatty liver and inadequate dietary intake of nutrients and energy. They showed that intake of high protein (>70 g/day), especially animal protein, was a risk factor for ALT elevation (odds ratio, 4.06; 95% confidence interval: 1.19–11.38).…”

Section: Discussionmentioning

confidence: 99%

Eating a healthy lunch improves serum alanine aminotransferase activity

et al. 2013

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BackgroundNutritional guidance and diet control play important roles in the treatment of obesity and non-alcoholic fatty liver. However, in Japan, nutritional guidance is difficult to provide in practice. Therefore, we evaluated the effects of providing the ‘once-a-day’ intervention of a healthy lunch on various metabolic parameters.MethodsFor a 1-month preparatory period, 10 subjects generally consumed the lunches that were provided by the worksite cafeteria. This was followed by a 1-week washout period, after which, the subjects consumed healthy, low-calorie, well-balanced lunches for a 1-month test period. After the preparatory and test periods, blood samples were obtained from all subjects. The serum levels of indices relevant to metabolic syndrome and fatty liver were measured.ResultsSerum alanine aminotransferase activity significantly decreased by 20.3% after the healthy intervention. However, the indices of metabolic syndrome did not significantly change. Analysis of the relationship between serum alanine aminotransferase activity and nutrient content indicated that the improvement of serum alanine aminotransferase status was due to the higher vegetable content and lower animal-source protein of the meals provided.ConclusionsIn summary, the ‘once-a-day’ intervention of providing a healthy lunch improved serum alanine aminotransferase status. A diet high in vegetables and low in animal-based protein is important in maintaining a healthy condition.

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Nutrient intake in Italian obese patients: Relationships with insulin resistance and markers of non-alcoholic fatty liver disease

Cited by 29 publications

References 23 publications

Effects of Unbalanced Polyunsaturated Fatty Acid Intake on Obesity-related Metabolic and Hepatic Dysfunctions

Effects of Unbalanced Polyunsaturated Fatty Acid Intake on Obesity-related Metabolic and Hepatic Dysfunctions

The Role of Nutrients in the Development, Progression, and Treatment of Nonalcoholic Fatty Liver Disease

Eating a healthy lunch improves serum alanine aminotransferase activity

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