Effects of Unbalanced Polyunsaturated Fatty Acid Intake on Obesity-related Metabolic and Hepatic Dysfunctions

Ricci, Giorgio; Canducci, E.; Guida, Ada; Arena, Rosario; Frascari, A.; Ravani, Bruna; Alvisi, Vittorio

doi:10.22606/mcmr.2017.12002

Cited by 1 publication

(1 citation statement)

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“…For instance, the ratios of ω-3 to ω-6 is not only essential in the production of eicosanoid metabolites that influence the inflammatory and homeostatic responses but also critical in the pathogenesis of diseases like diabetes [10,11]. The imbalances between the intake of ω-3 and ω-6 may lead to the imbalances in gene-nutrient interactions and endogenous mediators that may lead to biological consequences that influence the disease risk [12,13]. Other studies by [14,15] emphasized the need for replacing saturated fats with unsaturated fats as part of dietary controls towards the management of cardiovascular diseases.…”

Section: Resultsmentioning

confidence: 99%

Omega 3 versus Omega 6 Polyunsaturated Fatty Acids in Cardio-Metabolic Health

Halim

2020

J Health Care and Research

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Background: Cardiometabolic diseases like type 2 diabetes, metabolic syndrome, heart failure, and other cardiovascular complications are the leading cause of mortality and morbidity across the globe. These conditions are directly attributed to modifiable behaviors such as sedentary activity, poor diet, excessive consumption of alcohol, or smoking. Efforts aimed towards their prevention and management are, therefore, not only essential in the accomplishment of the healthy populations but also for eliminating the associated cost and health burdens. Dietary change is an important approach to the promotion of cardiometabolic health. Omega 3 (C20–22 ω3) polyunsaturated fatty acids have pleiotropic effects on the functioning of cells, control inflammatory factors, and cellular events in vascular endothelial cells and cardiomyocytes. The hypolipemic, anti-arrhythmic, and anti-inflammatory properties of fatty acids offer cardioprotection. Government agencies and national heart associations recommend increased consumption of omega 3 polyunsaturated fatty acids (PUFA) supplements and fish to prevent cardiometabolic diseases. Purpose of the Study: The purpose of this study is to investigate the role played by ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic health. Methods: The research study searched databases such as MEDLINE®, Embase, PsycINFO, CINAHL® and the Cochrane Library for relevant research studies evaluating the function/benefits of polyunsaturated fatty acids particularly ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic functions published between 2011 and 2020. A total of 77 research studies were identified and used in the meta-analysis. Results: Results from the meta-analysis indicated that polyunsaturated fatty acids lower the risk for cardiovascular disease by limiting inflammation of blood vessels, reducing thrombosis, increasing levels of high-density lipoproteins, reducing levels of low-density lipoproteins, and reducing risk factors associated with hypertension. Conclusion: Given the benefits of polyunsaturated fatty acids lower the risk for cardiovascular diseases indicted in the meta-analysis. Therefore, human diets must contain the required amounts of PUFA due to the associated benefits.

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