Nutrient control of Drosophila longevity

Tatar, Marc; Post, Stephanie; Yu, Kweon

doi:10.1016/j.tem.2014.02.006

Cited by 140 publications

(136 citation statements)

References 69 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…DR extends the life span of many animals, including Drosophila (Tatar et al 2014). In mice, gene expression profiles of methionine-restricted and calorie-restricted mice do not significantly overlap, suggesting that these two dietary regimens may affect longevity through partly independent pathways (Sun et al 2009).…”

Section: Noncanonical Functions Of Dahcy Proteins Are Not Involved Inmentioning

confidence: 99%

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila

et al. 2016

View full text Add to dashboard Cite

Aging is a risk factor for many human pathologies and is characterized by extensive metabolic changes. Using targeted high-throughput metabolite profiling in Drosophila melanogaster at different ages, we demonstrate that methionine metabolism changes strikingly during aging. Methionine generates the methyl donor S-adenosylmethionine (SAM), which is converted via methylation to S-adenosyl-homocysteine (SAH), which accumulates during aging. A targeted RNAi screen against methionine pathway components revealed significant life span extension in response to down-regulation of two noncanonical Drosophila homologs of the SAH hydrolase Ahcy (S-adenosyl-L-homocysteine hydrolase [SAHH[), CG9977/dAhcyL1 and Ahcy89E/CG8956/dAhcyL2, which act as dominant-negative regulators of canonical AHCY. Importantly, tissue-specific down-regulation of dAhcyL1/L2 in the brain and intestine extends health and life span. Furthermore, metabolomic analysis of dAhcyL1-deficient flies revealed its effect on age-dependent metabolic reprogramming and H3K4 methylation. Altogether, reprogramming of methionine metabolism in young flies and suppression of age-dependent SAH accumulation lead to increased life span. These studies highlight the role of noncanonical Ahcy enzymes as determinants of healthy aging and longevity.

show abstract

Section: Noncanonical Functions Of Dahcy Proteins Are Not Involved Inmentioning

confidence: 99%

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Moreover, while omission of Met extends lifespan, omission of tryptophan (Trp) does not increase survival, thus indicating the impact of Met availability on lifespan extension [34]. The impact of DR and AA restriction in flies has recently been reviewed extensively elsewhere [23]. …”

Section: Dietary Restriction and Lifespan In Worms And Fliesmentioning

confidence: 99%

Protein and amino acid restriction, aging and disease: from yeast to humans

Mirzaei

Suárez

Longo

2014

Trends in Endocrinology & Metabolism

213

158

View full text Add to dashboard Cite

Many of the effects of dietary restriction (DR) on longevity and health span in model organisms have been linked to reduced protein and amino acid (AA) intake and the stimulation of specific nutrient signaling pathways. Studies in yeast have shown that addition of serine, threonine, and valine in media promotes cellular sensitization and aging by activating different but connected pathways. Protein or essential AA restriction extends both lifespan and healthspan in rodent models. In humans, protein restriction (PR) has been associated with reduced cancer, diabetes, and overall mortality. Thus, interventions aimed at lowering the intake of proteins or specific AAs can be beneficial and have the potential to be widely adopted and effective in optimizing healthspan.

show abstract

“…Using this framework allows the use of nutritional geometry to simultaneously interpret the effects of energy, individual macronutrients (or other focal dietary components) and the interactions within and between nutrients (Piper et al 2011; Simpson and Raubenheimer 2012). This framework has helped to resolve conflicting ideas about the nutritional determinants of health and aging, and to reconcile views on resource-mediated trade-offs between reproduction and longevity (Jensen, et al 2015; Lee, et al 2008; Solon-Biet, et al 2015b; Tatar, et al 2014). …”

Section: Macronutrient Balancementioning

confidence: 99%

Macronutrients and caloric intake in health and longevity

Solon-Biet¹,

Mitchell²,

Cabo³

et al. 2015

Journal of Endocrinology

121

View full text Add to dashboard Cite

Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention known to extend life in many organisms, but recently the balance of macronutrients has been shown to play a critical role. In this review, we discuss the current understanding regarding the impact of calories and macronutrient balance in mammalian health and longevity and highlight the key nutrient-sensing pathways that mediate the effects of nutrition on health and ageing.

show abstract

Nutrient control of Drosophila longevity

Cited by 140 publications

References 69 publications

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila

Protein and amino acid restriction, aging and disease: from yeast to humans

Macronutrients and caloric intake in health and longevity

Contact Info

Product

Resources

About