Macronutrients and caloric intake in health and longevity

Solon-Biet, Samantha M.; Mitchell, Sarah J.; Cabo, Rafael de; Raubenheimer, David; Couteur, David G. Le; Simpson, Stephen J.

doi:10.1530/joe-15-0173

Cited by 121 publications

(77 citation statements)

References 121 publications

(164 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The data convincingly showed that the key factor driving the survival effect was the protein to carbohydrate ratio, not the calories. The same group recently reported that short-term exposure to three of the previously reported diets under AL and CR conditions led to a metabolic impact of CR on glucose homeostasis that was very similar to the AL group fed a low protein diet, and that CR plus the low protein diet did not add further benefit than CR alone (Solon-Biet et al, 2015). …”

Section: What Role Does Dietary Composition Play?mentioning

confidence: 93%

“…We have already covered in the previous sections some of the differential physiological responses that distinguish CR from protein restriction (PR) and other aspects of diet composition. The impact of various feeding regimens were recently extensively reviewed (Le Couteur et al, 2016a; Le Couteur et al, 2016b; Masoro, 2005, 2006; Solon-Biet et al, 2015; Speakman and Mitchell, 2011; Speakman et al, 2016). The role of optimal dietary composition for promoting lifespan extension in ad libitum or CR condition remains unknown.…”

Section: What Role Does Dietary Composition Play?mentioning

confidence: 99%

See 1 more Smart Citation

Calorie restriction in rodents: Caveats to consider

Ingram

Cabo

2017

Ageing Research Reviews

Self Cite

107

View full text Add to dashboard Cite

The calorie restriction paradigm has provided one of the most widely used and most useful tools for investigating mechanisms of aging and longevity. By far, rodent models have been employed most often in these endeavors. Over decades of investigation, claims have been made that the paradigm produces the most robust demonstration that aging is malleable. In the current review of the rodent literature, we present arguments that question the robustness of the paradigm to increase lifespan and healthspan. Specifically, there are several questions to consider as follows: (1) At what age does CR no longer produce benefits? (2) Does CR attenuate cognitive decline? (3) Are there negative effects of CR, including effects on bone health, wound healing, and response to infection? (4) How important is schedule of feeding? (5) How long does CR need to be imposed to be effective? (6) How do genotype and gender influence CR? (7) What role does dietary composition play? Consideration of these questions produce many caveats that should guide future investigations to move the field forward.

show abstract

Section: What Role Does Dietary Composition Play?mentioning

confidence: 93%

Section: What Role Does Dietary Composition Play?mentioning

confidence: 99%

Calorie restriction in rodents: Caveats to consider

Ingram

Cabo

2017

Ageing Research Reviews

Self Cite

107

View full text Add to dashboard Cite

show abstract

“…The positive relationship between the concentration of protein in the experimental diets and protein intakes suggests that the strong regulation of protein is not absolute; rather, high concentrations of fats and carbohydrates restricted protein intake to some extent, whereas low concentrations resulted in compensatory responses leading to excess protein intake, but to a lesser extent than protein influenced carbohydrate and fat (Figure 3) and total energy intake (Figure 2b). Given recent evidence relating high protein intakes to accelerated rates of aging and poor latelife cardiometabolic health, especially when coupled with low carbohydrate intakes (83,91,92), this analysis suggests that the interaction of appetite systems for protein, fats, and carbohydrates might provide a fundamental mechanism underlying the reason that AMDRs have both an upper and lower protein limit. The analysis also shows why high-protein diets (Figure 5), although effective for weight loss through limiting energy intake (Figure 2b) as a result of protein feedbacks (Figure 3), have been associated with unhealthy metabolic profiles and premature death (83,89).…”

Section: Figurementioning

confidence: 99%

Nutritional Ecology and Human Health

2016

Self Cite

View full text Add to dashboard Cite

In contrast to the spectacular advances in the first half of the twentieth century with micronutrient-related diseases, human nutrition science has failed to stem the more recent rise of obesity and associated cardiometabolic disease (OACD). This failure has triggered debate on the problems and limitations of the field and what change is needed to address these. We briefly review the two broad historical phases of human nutrition science and then provide an overview of the main problems that have been implicated in the poor progress of the field with solving OACD. We next introduce the field of nutritional ecology and show how its ecological-evolutionary foundations can enrich human nutrition science by providing the theory to help address its limitations. We end by introducing a modeling approach from nutritional ecology, termed nutritional geometry, and demonstrate how it can help to implement ecological and evolutionary theory in human nutrition to provide new direction and to better understand and manage OACD.

show abstract

“…Longevity-promoting genes include components of the insulin-like signaling pathway, the histone deacetylase Sir2, the GTPase Ras, TRP membrane channels, and transcription factors, among many others (1,2). Environmental manipulations extending life include changes in nutrition (often referred to as caloric or dietary restriction), sexual/reproductive history, and ambient temperature (3)(4)(5).…”

mentioning

confidence: 99%

The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan

Carvalho

Drago

Hoxha

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Changes in body temperature can profoundly affect survival. The dramatic longevity-enhancing effect of cold has long been known in organisms ranging from invertebrates to mammals, yet the underlying mechanisms have only recently begun to be uncovered. In the nematode Caenorhabditis elegans, this process is regulated by a thermosensitive membrane TRP channel and the DAF-16/FOXO transcription factor, but in more complex organisms the underpinnings of cold-induced longevity remain largely mysterious. We report that, in Drosophila melanogaster, variation in ambient temperature triggers metabolic changes in protein translation, mitochondrial protein synthesis, and posttranslational regulation of the translation repressor, 4E-BP (eukaryotic translation initiation factor 4E-binding protein). We show that 4E-BP determines Drosophila lifespan in the context of temperature changes, revealing a genetic mechanism for cold-induced longevity in this model organism. Our results suggest that the 4E-BP pathway, chiefly thought of as a nutrient sensor, may represent a master metabolic switch responding to diverse environmental factors.S tudies on the biological underpinnings of aging have uncovered numerous genetic and environmental factors regulating animal lifespan. Longevity-promoting genes include components of the insulin-like signaling pathway, the histone deacetylase Sir2, the GTPase Ras, TRP membrane channels, and transcription factors, among many others (1, 2). Environmental manipulations extending life include changes in nutrition (often referred to as caloric or dietary restriction), sexual/reproductive history, and ambient temperature (3-5).Of the factors known to impact aging, temperature is arguably the most promising. Lifespan extension by cold is evolutionarily conserved-documented in poikilotherms, such as worms and flies, and homeotherms, including mammals (4, 6-11)-and more robust than well-studied interventions such as dietary restriction (12, 13). However, the underlying mechanisms remain incompletely understood (10,14,15). In Caenorhabditis elegans, the effect of cold on survival involves the thermosensitive membrane channel TRPA-1 acting upstream of the DAF-16/FOXO transcription factor (14,15). This seminal finding countered the notion that longevity is the passive result of general thermodynamic changes, and favored instead the view that genetic pathways actively control lifespan in response to ambient temperature. However, these results have to date not been extended or replicated in other model organisms. Explanatory theories for the effect of cold on longevity include a reduction in reactive oxygen species generated by mitochondrial uncoupling proteins, suppression of autoimmune response, and changes in neuroendocrine factors (6,16,17), but these views remain largely speculative given the lack of further mechanistic insight into lifespan extension by cold in model organisms.We report that, in Drosophila, changes in temperature trigger a metabolic program impacting protein translation, mitochondrial prot...

show abstract

Macronutrients and caloric intake in health and longevity

Cited by 121 publications

References 121 publications

Calorie restriction in rodents: Caveats to consider

Calorie restriction in rodents: Caveats to consider

Nutritional Ecology and Human Health

The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan

Contact Info

Product

Resources

About