Nutricel as an additive solution for neonatal transfusion

Guidelines for assessing appropriateness of pediatric transfusion

“…A variety of clinical trials and mathematical models have concluded that blood preserved in AS is safe when used for small‐volume (5‐15 mL/kg) transfusions and may actually improve blood glucose homeostasis 35,36 . The safety and efficacy of the use of AS‐3, which contains no mannitol but 30 mg per 100 mL AS‐3 of adenine, has also been shown to be safe for small‐volume neonatal transfusion 37,38 . AS‐5 is also used in blood collection, but there are currently no published studies in the neonatal population.…”

Data‐driven blood banking practices for neonatal RBC transfusions

“…However, three of these studies 10–12 included relatively few transfusions of RBCs actually stored longer than 14 days and did not address the use of extended‐storage anticoagulant or preservative solutions, as are commonly used at the present time. Moreover, on the basis of in vitro studies of AS‐3, concerns were raised about levels of potassium, phosphate, glucose, and citrate in RBCs stored in extended‐storage media for neonatal transfusions 16 . Accordingly, data from studies of AS‐1 and AS‐3 RBCs stored up to 42 days before transfusion to preterm infants 8,9 will be summarized in detail in the following paragraphs.…”

“…Moreover, on the basis of in vitro studies of AS-3, concerns were raised about levels of potassium, phosphate, glucose, and citrate in RBCs stored in extended-storage media for neonatal transfusions. 16 Accordingly, data from studies of AS-1 and AS-3 RBCs stored up to 42 days before transfusion to preterm infants 8,9 will be summarized in detail in the following paragraphs.…”

“…Whole blood 78 09 Whole blood 79 10 Whole blood 80 11 Whole blood 81 12 Whole blood 82 13 Whole blood 83 14 Whole blood 73 15 Whole blood, WBCs 80 16 Whole blood, RBCs 84 17…”