Numerical investigation of hyperelastic wall deformation characteristics in a micro-scale stenotic blood vessel

Abstract

Stenosis is the drastic reduction of blood vessel diameter because of cholesterol accumulation in the vessel wall. In addition to the changes in blood flow characteristics, significant changes occur in the mechanical behavior of a stenotic blood vessel. We conducted a 3-D study of such behavior in micro-scale blood vessels by considering the fluid structure interaction between blood flow and vessel wall structure. The simulation consisted of one-way coupled analysis of blood flow and the resulting structural deformation without a moving mesh. A commercial code based on a finite element method with a hyperelastic material model (Neo-Hookean) of the wall was used to calculate wall deformation. Three different cases of stenosis severity and aspect ratios with and without muscles around the blood vessel were considered. The results showed that the wall deformation in a stenotic channel is directly related to stenosis severity and aspect ratio. The presence of muscles reduces the degree of deformation even in very severe stenosis.

Effect of Arteriolar Distensibility on the Lateral Migration of Liquid-Filled Microparticles Flowing in a Human Arteriole

“…These components are dynamically interconnected making the frontiers blurred between the three layers. We limit the arteriolar wall to the inner layer (the intima) which is modeled as a nearly-incompressible hyperelastic material 28 following the neo-Hookean solid model (Eq. ( 3)).…”

Investigation of passive oscillations of flexible splitter plates attached to a circular cylinder

“…A description of Comsol FEA solvers and finite element scheme used to solve partial differential equations of the problem can be found in our previous work (Abdi et al, 2017). Further information regarding the solution method and efficiency of the solver can also be found from Cheema and Park (2013) and Ong et al (2013) studies.…”

Effect of Wall Flexibility on the Deformation during Flow in a Stenosed Coronary Artery

“…However, it is well known that arteries have flexible walls which primarily exhibit anisotropic non-linear elastic response (see review in [5] for a list of models that capture the anisotropic behavior of artery walls). Few studies have incorporated such representative models of arteries when simulating blood flow: most studies prefer to use approximations like thin-shell [6], Linear Elastic model [7], Neo-Hookean [8], Mooney-Rivlin model [9], or modified Mooney-Rivlin model [10] for the artery wall. Further, such studies [10,11] have typically concerned themselves with obtaining stress distributions in the arterial cross-section and overlapping them with plaque composition so as to gain insights into the effect of plaque composition on stress distribution and possible rupture.…”