The study of artificial microparticules (capsules and vesicles) has gained a growing interest with the emergence of bioengineering. One of their promoting applications is their use as therapeutic vectors for drug delivery, when capsules and vesicles release their capacity in a targeted environment. The dynamic behavior of capsules and vesicles in confined or unbounded flows was widely studied in the literature and their mechanical response was truthfully described using constitutive laws with good agreement with experiences. However, in a context of biological application, to our knowledge, none of published studies investigating the mechanical response of deformable microparticle took into account the real physiological conditions: the rheological properties of blood such as carrying fluid and the mechanical properties of blood vessels. In this paper, we considered a hyperelastic microparticle suspended in human arteriole. We investigate the deformation of the microparticle resulting from its interaction with blood flow and the arterial wall using various capillary numbers and respecting physiological properties of blood and arterial wall. The influence of the blood viscosity model (Newtonian vs shear-thinning) is investigated and a comparison with a rigid microchannel is carried out. The fluid structure interaction (FSI) problem is solved using Arbitrary Lagrangian Eulerian (ALE) method.
A promising advance of bioengineering consists in the development of micro-nanoparticles as drug delivery vehicles injected intravenously or intraarterialy for targeted treatment. Proficient functioning of drug carries is conditioned by a reliable prediction of pharmacokinetics in human as well as their dynamical behavior once injected in blood stream. In this study, we aim to provide a reliable numerical prediction of dynamical behavior of microparticles in human arteriole focusing on the crucial mechanism of lateral migration. The dynamical response of the microparticle upon blood flow and arteriolar distensibility is investigated by varying main controlling parameters: viscosity ratio, confinement and capillary number. The influence of the hyperelastic arteriolar wall is highlighted through comparison with an infinitely rigid arteriolar wall. The hydrodynamic interaction in a microparticle train is examined. Fluid–structure interaction is solved by the Arbitrary Lagrangian–Eulerian method using the COMSOL Multiphysics software.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.