Effect of Wall Flexibility on the Deformation during Flow in a Stenosed Coronary Artery

Kallekar, Laxman; Chinthapenta, Viswanath; Mohan, Anand

doi:10.3390/fluids2020016

Cited by 16 publications

(8 citation statements)

References 15 publications

(22 reference statements)

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“…With the accumulation of fat, the flexibility of artery was decreased and its interior space became narrow. The plaque was gradually formed in the inner wall of the artery and caused the tightness of blood vessel (Kallekar, Viswanath, & Anand, ). Hypercholesterolemia reduced the production and secretion of vasodilators deriving from endothelium and enhanced the generation of superoxide radicals in arteries.…”

Section: Discussionmentioning

confidence: 99%

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Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Parvin

Yaghmaei

Noureddini

et al. 2019

Food Science & Nutrition

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The use of herbal remedies is significantly considered in the atherosclerosis treatment, reduction of fatty elements, and prevention of activity of oxidative stress factors. The present study was conducted on 48 rats in 6 groups. The experimental and sham groups were fed with 2% cholesterol for 40 days; and experimental groups were separately treated by atorvastatin, quercetin, and hydroalcoholic extract for 4 weeks. After treatment procedure, some serum factors such as low‐density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA), and reactive oxygen species (ROS) were evaluated. Serum levels of LDL, TC, MDA, and ROS were significantly lower in experimental groups than sham group (p < .01). There was a significant decrease in serum MDA levels of these two groups in comparison with the atorvastatin‐treated group (p < .05). Blood pressure parameters were decreased in treated with quercetin and hydroalcoholic extract in comparison with the sham group (p < .05). Quercetin and hydroalcoholic extract similar to atorvastatin could decrease serum lipids [except high‐density lipoprotein (HDL)], oxidative stress factors, aorta contraction, weight gain, and blood pressure. These reagents improved the vascular structure and prevented the plaque formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Parvin

Yaghmaei

Noureddini

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Furthermore, hemodynamic studies mainly assume the wall to be rigid, however, over the years, fluid-structure interaction (FSI) has received increasing interest due to its ability to simultaneously model blood flow and arterial wall deformations [79,81,[98][99][100][101]. Among the several investigations that have emerged in this area, one of the most cited works in the literature was performed by Torii et al, (2009) [99], wherein the effects of compliance in WSS calculations were studied.…”

Section: Turbulence Modeling and Wall Assumptionsmentioning

confidence: 99%

Blood Flow Modeling in Coronary Arteries: A Review

Carvalho

Pinho

Lima

et al. 2021

Fluids

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Atherosclerosis is one of the main causes of cardiovascular events, namely, myocardium infarction and cerebral stroke, responsible for a great number of deaths every year worldwide. This pathology is caused by the progressive accumulation of low-density lipoproteins, cholesterol, and other substances on the arterial wall, narrowing its lumen. To date, many hemodynamic studies have been conducted experimentally and/or numerically; however, this disease is not yet fully understood. For this reason, the research of this pathology is still ongoing, mainly, resorting to computational methods. These have been increasingly used in biomedical research of atherosclerosis because of their high-performance hardware and software. Taking into account the attempts that have been made in computational techniques to simulate realistic conditions of blood flow in both diseased and healthy arteries, the present review aims to give an overview of the most recent numerical studies focused on coronary arteries, by addressing the blood viscosity models, and applied physiological flow conditions. In general, regardless of the boundary conditions, numerical studies have been contributed to a better understanding of the development of this disease, its diagnosis, and its treatment.

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Section: Introductionmentioning

confidence: 99%

“…The handicap of the recent two studies is that the vessel wall was assumed as a rigid body. But blood pulsatile causes deformation on the vessel wall, which can affect blood hemodynamics significantly (Kallekar, Viswanath, & Anand, 2017). Some researchers tried to simulate the interaction between blood flow and vessel wall using CFD analysis (Urquiza, Blanco, Vénere, & Feijóo, 2006), (Selmi, Belmabrouk, & Bajahzar, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effect Of Microvessels Stiffness on Hemodynamic; an FSI Analysis

Davar

2020

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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The exploitation of computer modelling in the study of cardiovascular disease has recently gained significant progress. In this study, the effect of microvessels stiffness on blood pressure and blood flow-induced wall shear stress (WSS) was analysed numerically. Three microvessels with diameters of 100, 200 and 300 microns and respectively media thicknesses of 10, 20 and 30 microns, were designed. Then for each model, three different elastic moduli of 0.4, 0.6 and 0.8 MPa were assigned. The blood flow within the microvessels was investigated using CFD analysis. A fluid-structure interaction (FSI) multiphysics analysis was performed to observe the effect of vascular stiffness on blood pressure and vice versa the effect of blood flow on the microvessel deformation. The result of the analysis showed that increasing the stiffness of a vessel increases blood pressure and WSS, and as well as causes a decrease in its deformability. The outcomes of this theoretical study shed more light on the understanding of cardiovascular diseases roots and origin, especially in micron-sized vessels..

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Effect of Wall Flexibility on the Deformation during Flow in a Stenosed Coronary Artery

Cited by 16 publications

References 15 publications

Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Blood Flow Modeling in Coronary Arteries: A Review

Effect Of Microvessels Stiffness on Hemodynamic; an FSI Analysis

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