In highly loaded tandem compressor cascades, corner separations can still exist. In order to eliminate corner separations in highly loaded tandem compressor cascades, incoming vortex–corner separation interaction mechanism was investigated. Different schemes of the vortex generators, which located at different pitchwise locations and could generate vortexes with different rotation directions, were designed and investigated numerically. Results show that, severe corner separation occurred at the front blade passage of the tandem cascade; by utilizing flow control method of incoming vortex–corner separation interaction, the corner separation could be reduced significantly. The optimal control effect of incoming vortex on corner separation was achieved with anticlockwise rotation and the vortex generator is located right ahead of the leading edge of tandem cascade, a maximum loss coefficient reduction of 21.8% being achieved. Different from single blade configuration, the boundary layer of tandem cascade was regenerated at rear blade suction surface due to the injection flow from blade gap between the two blades. Though corner separations could be reduced at both conditions, the loss of tandem cascade with clockwise incoming vortex is higher than that with anticlockwise vortex, and a smaller corner separation region at suction surface was achieved by utilizing clockwise vortex. The mechanism was that anticlockwise incoming vortex reduced the corner separation but increased secondary flow, while clockwise vortex enhanced passage vortex and decreased secondary flow. For clockwise incoming vortex near pressure surface, the vortex would be divided into two parts at the leading edge of rear blade, one would go through the blade gap and deteriorate flow fluid near rear blade suction surface, the other flowed downstream along pressure surface. The rotation direction of different incoming vortexes became the same as the passage vortex at rear blade passage of tandem cascade, which was mainly due to the effect of secondary flow.